Výsledky vyhledávání - "Yulissa Gonzalez"

Addressing the needs of parents with advanced cancer: Attitudes, practice behaviors, and training experiences of oncology social workers

Autor: Nancy A. Borstelmann, Kate E. Stanton, Courtney A Nelson, Samantha M Yi, Savannah M Bowers, Yulissa Gonzalez, Catherine L Swift, Stephanie A. Chien, Eliza M. Park, Laura J. Quillen

Publikováno v: Palliat Support Care

ObjectiveAdvanced cancer patients who are parents of minor children experience heightened psychosocial distress. Oncology social workers (OSWs) are essential providers of psychosocial support to parents with advanced cancer. Yet, little is known abou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5270e47f67a62b72439a28dbcebe2e6e
https://pubmed.ncbi.nlm.nih.gov/32985404

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Chromatin-Remodeled State in Lymphoma

Autor: Jennifer E Amengual, Yulissa Gonzalez, Yuxuan Liu

Publikováno v: Curr Hematol Malig Rep

PURPOSE OF REVIEW: Emerging evidence has shown that epigenetic derangements might drive and promote tumorigenesis in various types of malignancies and is prevalent in both B cell and T cell lymphomas. The purpose of this review is to explain how the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d39cdc3c8d5104fd45ea45f1e08c923
https://pubmed.ncbi.nlm.nih.gov/31489524

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Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas

Autor: Jennifer E Amengual, Emily I. Chen, Neil L. Kelleher, Olivier Elemento, Prabhjot Mundi, Jennifer K. Lue, Nebiyu Abshiru, Jeannie M. Camarillo, Yulissa Gonzalez, Changhong Qiao, Serge Cremers, Sathyen A. Prabhu, Swasti Mehta, Renu Nandakumar, Akanksha Verma, Yuxuan Liu

Publikováno v: Clin Cancer Res

Purpose: Both gain-of-function enhancer of zeste homolog 2 (EZH2) mutations and inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been implicated in the pathogenesis of germinal center (GC)–derived lymphomas. We hypo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bfd15b80a8e16bf6e1462112f4363f
https://pubmed.ncbi.nlm.nih.gov/30979734

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Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators

Autor: Howook Hwang, Elisa Zuccarello, Jennifer E Amengual, Yulissa Gonzalez, Shixian Deng, Yuxuan Liu, Elisa Calcagno, Jole Fiorito, Brian Estrella, Owen A. O'Connor, Donald W. Landry, Barry Honig, Ottavio Arancio

Publikováno v: Blood. 134:4068-4068

Epigenetic dysregulation is a hallmark of germinal center derived B cell lymphomas. In particular, the monoallelic mutations in histone acetyltransferases (HATs), p300 and CBP are present in approximately 40% of DLBCL and FL patients. The haploinsuff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f1906fa844cc0e4cb791f8a3af8b935
https://doi.org/10.1182/blood-2019-125983

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Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib

Autor: Owen A. O'Connor, Xavier O. Jirau Serrano, Kelly Zullo, Jennifer E Amengual, Serge Cremers, Yulissa Gonzalez, Olivier Elemento, Luigi Scotto, Renu Nandakumar, Sathyen A. Prabhu, Maximilian Lombardo, Jimmy Duong, Ying Wei, Paul Johannet, Akanksha Verma

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 23(12)

Purpose: Pan-class I/II histone deacetylase (HDAC) inhibitors are effective treatments for select lymphomas. Isoform-selective HDAC inhibitors are emerging as potentially more targeted agents. ACY-1215 (ricolinostat) is a first-in-class selective HDA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63825a157e4938b04de126f5a99c0f0
https://pubmed.ncbi.nlm.nih.gov/27993968

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Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma

Autor: Adolfo Mazzeo, Yuxuan Liu, Owen A. O'Connor, Jennifer E Amengual, Shixian Deng, Elisa Calcagno, Cremers Serge, Elisa Zuccarello, Nebiyu Abshiru, Yulissa Gonzalez, Jeannie M. Camarillo, Donald W. Landry, Jole Fiorito, Changhong Qiao, Neil L. Kelleher, Ottavio Arancio, Renu Nandakumar

Publikováno v: Blood. 132:37-37

Monoalleleic inactivating mutations in histone acetyltransferase (HAT) enzymes promote lymphomagenesis in germinal center derived B-cell lymphomas, follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL), occurring in about 40% of patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba70668e1c2fae2d194cf0a84b7e98da
https://doi.org/10.1182/blood-2018-99-110447

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A basal gene expression signature to predict for synergy of combined EZH2 and HDAC inhibition in EZH2 dysregulated lymphomas

Autor: Yuxuan Liu, Serge Cremers, Changhong Qiao, Renu Nandakumar, Sathyen A. Prabhu, Jennifer E Amengual, Akanksha Verma, Neil L. Kelleher, Jennifer K. Lue, Nebiyu Abshiru, Yulissa Gonzalez, Emily I. Chen, Olivier Elemento

Publikováno v: Journal of Clinical Oncology. 36:7546-7546

7546Background: EZH2 is the catalytic subunit of PRC2, and induces methylation of H3K27. Activating mutations and overexpression of EZH2 are found in NHL. Inactivating mutations in histone acetyltr...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42ef45fd97a95b8019a3e5bdcbfd1acb
https://doi.org/10.1200/jco.2018.36.15_suppl.7546

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