Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yulia V. Dobryakova"'
Autor:
Yulia V. Dobryakova, Yulia S. Spivak, Maria I. Zaichenko, Alena A. Koryagina, Vladimir A. Markevich, Mikhail Yu. Stepanichev, Alexey P. Bolshakov
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
One of the aspects of Alzheimer disease is loss of cholinergic neurons in the basal forebrain, which leads to development of cognitive impairment. Here, we used a model of cholinergic deficit caused by immunotoxin 192IgG-saporin to study possible ben
Externí odkaz:
https://doaj.org/article/5eddee55a8b549fe98ce6f3db2e8bfe3
Autor:
Yulia V. Dobryakova, Maria N. Volobueva, Anna O. Manolova, Tatiana M. Medvedeva, Alexey A. Kvichansky, Natalia V. Gulyaeva, Vlamidir A. Markevich, Mikhail Yu. Stepanichev, Alexey P. Bolshakov
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer’s disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial sept
Externí odkaz:
https://doaj.org/article/c6493ee6918244acaafc1ffde7b42e22
Autor:
Alexey P. Bolshakov, Mikhail Yu. Stepanichev, Yulia V. Dobryakova, Yulia S. Spivak, Vladimir A. Markevich
Publikováno v:
Toxins, Vol 12, Iss 9, p 546 (2020)
Saporin, which is extracted from Saponaria officinalis, is a protein toxin that inactivates ribosomes. Saporin itself is non-selective toxin but acquires high specificity after conjugation with different ligands such as signaling peptides or antibodi
Externí odkaz:
https://doaj.org/article/841b3ca7190b41b9a663a6ed37d030fe
Autor:
Yulia V. Dobryakova, Artem Kasianov, Maria I. Zaichenko, Mikhail Y. Stepanichev, Ekaterina A. Chesnokova, Petr M. Kolosov, Vladimir A. Markevich, Alexey P. Bolshakov
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2018)
One of important aspects of development of Alzheimer’s disease is degeneration of septal cholinergic neurons that innervate the hippocampus. We took advantage of widely used model of cholinergic deficit in the hippocampus, intracerebroventricular a
Externí odkaz:
https://doaj.org/article/2fdf8b0d4a2e4ff5a7cd5dd8f98e47c1
Autor:
Alexander Beletskiy, Ekaterina Positselskaya, Aliya Kh. Vinarskaya, Yulia S. Spivak, Yulia V. Dobryakova, Iliya Tyulenev, Vladimir A. Markevich, Alexey P. Bolshakov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9948
We performed RNA sequencing of the dorsal and ventral parts of the hippocampus and compared it with previously published data to determine the differences in the dorsoventral gradients of gene expression that may result from biological or technical v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd384ff2ae105133d895d64cfe0fd4ac
https://pubmed.ncbi.nlm.nih.gov/36077346
https://pubmed.ncbi.nlm.nih.gov/36077346
Publikováno v:
International Journal of Neuroscience. 132:490-496
The role of cholinergic neurotransmission in the hippocampus remains controversial since different studies showed either no influence or its modulatory effect on glutamatergic hippocampal synapses. It remains unclear whether septal cholinergic input
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64123e34289c6d9f1647002433388d4
https://doi.org/10.1080/00207454.2020.1822834
https://doi.org/10.1080/00207454.2020.1822834
Publikováno v:
Neuroscience and Behavioral Physiology. 50:575-580
The Wnt signal pathway plays a significant role in regulating synaptic plasticity. We have previously shown that chronic suppression of the Wnt cascade induces impairment of long-term potentiation (LTP) in vivo, while chronic overexpression of Wnt3 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9327fa2b8ddf9fd4cee2ceacdb672a
https://doi.org/10.1007/s11055-020-00938-7
https://doi.org/10.1007/s11055-020-00938-7
Autor:
Yulia S. Spivak, Anna A. Karan, Yulia V. Dobryakova, Tatiana M. Medvedeva, Vladimir A. Markevich, Alexey P. Bolshakov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 11; Pages: 6034
We studied the effects of stimulation of the medial septal area on the gene expression in the dorsal and ventral hippocampus. Rats under urethane anesthesia were implanted with a recording electrode in the right hippocampus and stimulating electrode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa4161bc81aa817cfeae832b69f6a93
https://pubmed.ncbi.nlm.nih.gov/35682713
https://pubmed.ncbi.nlm.nih.gov/35682713
Autor:
Yulia V Dobryakova, Mikhail Stepanichev, Vladimir A Markevich, Yulia S Spivak, A. P. Bolshakov
Publikováno v:
Toxins, Vol 12, Iss 546, p 546 (2020)
Saporin, which is extracted from Saponaria officinalis, is a protein toxin that inactivates ribosomes. Saporin itself is non-selective toxin but acquires high specificity after conjugation with different ligands such as signaling peptides or antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cf14292f45d9a0cb25c34c119aad40
https://www.mdpi.com/2072-6651/12/9/546
https://www.mdpi.com/2072-6651/12/9/546
Autor:
Alexey P, Bolshakov, Mikhail Yu, Stepanichev, Yulia V, Dobryakova, Yulia S, Spivak, Vladimir A, Markevich
Publikováno v:
Toxins
Saporin, which is extracted from Saponaria officinalis, is a protein toxin that inactivates ribosomes. Saporin itself is non-selective toxin but acquires high specificity after conjugation with different ligands such as signaling peptides or antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bf42f4af5243fc58cb7afb197e10252
https://pubmed.ncbi.nlm.nih.gov/32854372
https://pubmed.ncbi.nlm.nih.gov/32854372