Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar.

Autor: Charlotte Isch, Paul Majneri, Nicolas Landrein, Yulia Pivovarova, Johannes Lesigang, Florian Lauruol, Derrick R Robinson, Gang Dong, Mélanie Bonhivers

Publikováno v: PLoS Pathogens, Vol 17, Iss 8, p e1009329 (2021)

The flagellar pocket (FP) is the only endo- and exocytic organelle in most trypanosomes and, as such, is essential throughout the life cycle of the parasite. The neck of the FP is maintained enclosed around the flagellum via the flagellar pocket coll

Externí odkaz: https://doaj.org/article/342552844d3f4eaabbb926a00273446c

Crystal structure of the N-terminal domain of the trypanosome flagellar protein BILBO1 reveals a ubiquitin fold with a long structured loop for protein binding

Autor: Keni Vidilaseris, Gang Dong, Nicolas Landrein, Johannes Lesigang, Derrick R. Robinson, Niran Aeksiri, Mélanie Bonhivers, Yulia Pivovarova

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (6), pp.1489-1499. ⟨10.1074/jbc.RA119.010768⟩
J Biol Chem
'Journal of Biological Chemistry ', vol: 295, pages: 1489-1499 (2020)

International audience; Trypanosoma brucei is a protist parasite causing sleeping sickness and nagana in sub-Saharan Africa. T. brucei has a single flagellum whose base contains a bulblike invagination of the plasma membrane called the flagellar pock

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb63aa6873387238d984c336f5afc19
https://hal.archives-ouvertes.fr/hal-02482599/document