Výsledky vyhledávání - "Yulia Merkulova"

Akademický článek

The transcription factor Myt3 acts as a pro-survival factor in β-cells.

Autor: Bryan R Tennant, Ratib Islam, Marabeth M Kramer, Yulia Merkulova, Roger L Kiang, Cheryl J Whiting, Brad G Hoffman

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51501 (2012)

We previously identified the transcription factor Myt3 as specifically expressed in pancreatic islets. Here, we sought to determine the expression and regulation of Myt3 in islets and to determine its significance in regulating islet function and sur

Externí odkaz: https://doaj.org/article/3f1d7bf15ff04dadae37bd48eb220208

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Granzyme B Deficiency Protects against Angiotensin II Induced Cardiac Fibrosis

Autor: Yue Shen, Tatjana Bozin, Lubos Bohunek, John E. Eriksson, Lisa S. Ang, Yulia Merkulova, Ivy Hsu, Fang Cheng, David J. Granville, Kathryn Westendorf, Bruce M. McManus, Sheetal A. Raithatha, Sarah J. Williams, Hongyan Zhao, Michael A. Seidman, Leigh G. Parkinson, Mehul Sharma, R. Chris Bleackley

Publikováno v: American Journal of Pathology. 186(1):87-100

Cardiac fibrosis is observed across diverse etiologies of heart failure. Granzyme B (GzmB) is a serine protease involved in cell-mediated cytotoxicity in conjunction with the pore-forming protein, perforin. Recent evidence suggests that GzmB also con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a94d97c4e78fbdc5b8b7782da6d2c4
http://juuli.fi/Record/0278084316

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Abstract 487: Systemic Administration of Target-Seeking, Vessel Penetrating Recombinant Decorin Fusion Protein, Car-DCN, Reduces Severity of Abdominal Aortic Aneurysm in Mice

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 37

Objective: Decorin (DCN) is a small leucine-rich proteoglycan that mediates collagen fibrollogenesis, organization, and tensile strength. DCN is reduced in abdominal aortic aneurysm (AAA) through a Granzyme B-dependent mechanism resulting in vessel w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3be07cdf212aaa9acebf48688c02c360
https://doi.org/10.1161/atvb.37.suppl_1.487

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Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports

Decorin (DCN) is a small-leucine rich proteoglycan that mediates collagen fibrillogenesis, organization, and tensile strength. Adventitial DCN is reduced in abdominal aortic aneurysm (AAA) resulting in vessel wall instability thereby predisposing the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0945193c438d896240ed47e6ffb58e66
https://trepo.tuni.fi/handle/10024/102562

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Granzyme B inhibits keratinocyte migration by disrupting epidermal growth factor receptor (EGFR)-mediated signaling

Autor: Yulia Merkulova, Mehul Sharma, Hongyan Zhao, Leigh G. Parkinson, Kathryn Westendorf, Sheetal A. Raithatha, Robert Chris Bleackley, Yue Shen, David J. Granville

Publikováno v: Biological chemistry. 397(9)

Chronic non-healing wounds including diabetic, venous, and decubitus skin ulcers are currently lacking effective therapies. Non-healing diabetic ulcers can lead to amputations as progress into a highly chronic state before detection and existing trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63141cab50cbecb7a81ccea80f243e38
https://pubmed.ncbi.nlm.nih.gov/27060743

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Abstract 11078: Granzyme B Deficiency Protects Against Angiotensin II-induced Cardiac Fibrosis via a Perforin-independent Mechanism

Autor: Yue Shen, Fang Cheng, Mehul Sharma, Yulia Merkulova, Sheetal A Raithatha, Leigh G Parkinson, Hongyan Zhao, Kathryn Westendorf, Lubos Bohunek, Tatjana Bozin, Ivy Hsu, Lisa S Ang, Sarah J Williams, R C Bleackley, John E Eriksson, Michael A Seidman, Bruce M McManus, David J Granville

Publikováno v: Circulation. 132

Introduction: Granzyme B (GzmB) is a serine protease involved in immune cell-mediated apoptosis that is enabled through a mechanism involving the pore-forming protein, perforin that facilitates internalization. However, recent evidence suggests that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1f7b136740ad3af8d732e59ac368bfc
https://doi.org/10.1161/circ.132.suppl_3.11078

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An Integrated Analysis of Heterogeneous Drug Responses in Acute Myeloid Leukemia That Enables the Discovery of Predictive Biomarkers

Autor: Mark D. Minden, Sofie Perdu, Amanda Mitchell, Donna E. Hogge, Yulia Merkulova, Nathan Mbong, John E. Dick, Stevan Lauriault, Yan Xing, Cynthia J. Guidos, Goce Bogdanoski, Gitte Gerhard, Jessica McLeod, Weihsu C. Chen, Jean C.Y. Wang, Julie S. Yuan, James A. Kennedy, Andreea C. Popescu

Publikováno v: Cancer research. 76(5)

Many promising new cancer drugs proceed through preclinical testing and early-phase trials only to fail in late-stage clinical testing. Thus, improved models that better predict survival outcomes and enable the development of biomarkers are needed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719c5ceb629b05bda21240b825b2f96a
https://pubmed.ncbi.nlm.nih.gov/26833125

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