Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Yulia Maxuitenko"'
Autor:
Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J. Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B. Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A. Piazza, Vincenzo De Laurenzi, Gianluca Sala, Marco Falasca
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal disease, lacking effective therapeutic approaches. Available therapies only marginally prolong patient survival and are frequently coupled with severe adverse eve
Externí odkaz:
https://doaj.org/article/84712f0b99aa425c917bb4104624a84d
Autor:
Jeremy B. Foote, Tyler E. Mattox, Adam B. Keeton, Forrest Smith, Kristly L. Berry, Antonio B. Ward, Karina J. Yoon, Sujith Sarvesh, Ganji P. Nagaraju, Yulia Maxuitenko, Xi Chen, Jacob Valiyaveettil, Julienne L. Carstens, Jennifer Yang, Donald J. Buchsbaum, Gang Zhou, Elmar Nurmmedov, Ivan Babic, Vadim Gaponenko, Hazem Abdelkarim, Michael R. Boyd, Bassel F. El-Rayes, Gary A. Piazza
Here we describe a novel class of pan-RAS inhibitor with highly potent and selective anticancer activity by killing cancer cells harboring mutations in RAS or with constitutively activated RAS resulting from mutations in upstream signaling components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d76ea95ba86d6555f147a6ab3d6b4a1
https://doi.org/10.1101/2023.05.17.541233
https://doi.org/10.1101/2023.05.17.541233
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd1f8dd00b73f74f39564ed161f568a
https://doi.org/10.1158/1940-6207.22533268
https://doi.org/10.1158/1940-6207.22533268
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
HPLC chromatogram of ADT 061
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b66933ddc1218fa7030aec152176d5c
https://doi.org/10.1158/1940-6207.22533286.v1
https://doi.org/10.1158/1940-6207.22533286.v1
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
HPLC chromatogram of compound 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dbfc3c3f3c9bf58f3207098508123b
https://doi.org/10.1158/1940-6207.22533301.v1
https://doi.org/10.1158/1940-6207.22533301.v1
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
AST and ALT activity of male APC+/Min-FCCC mice administered varying doses of ADT 061 in the diet. Enzyme activity was measured in plasma samples. Results are presented as mean {plus minus} SEM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cd98d432962a31f53569fe3e05fb82
https://doi.org/10.1158/1940-6207.22533271
https://doi.org/10.1158/1940-6207.22533271
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
Reaction steps for synthesis of ADT 061 (a) 3-(4-methoxyphenyl)-2-methylacrylic acid (compound 1): 4-Methoxybenzaldehyde (219 g, 1.61 mole), propionic anhydride (315g, 2.42 mole), and sodium propionate (155g, 1.61 mole) were stirred at 140 ºC unti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd02d02bcdfbad1ca60d30e0de1f76d
https://doi.org/10.1158/1940-6207.22533310
https://doi.org/10.1158/1940-6207.22533310
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
Mass spectroscopy of compound 5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c1b9ab47b1ad6c6194c30774cc23c8
https://doi.org/10.1158/1940-6207.22533298
https://doi.org/10.1158/1940-6207.22533298
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
ADT 061 pharmacokinetics and tissue distribution. ADT 061 was detected in plasma at a concentration of 2.8 µM 0.5 hr after a single oral administration of a dose of 100 mg/kg in 0.5% CMC/0.25% T80 in water to female C57BL/6 mice and reached plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c071102f503fd37a06478fea5a9053
https://doi.org/10.1158/1940-6207.22533274
https://doi.org/10.1158/1940-6207.22533274
Autor:
Gary A. Piazza, Margie L. Clapper, Harry S. Cooper, Adam B. Keeton, Gang Zhou, Lori Coward, Greg Gorman, Elmar Nurmemmedov, Mary Pat Moyer, Yulia Maxuitenko, Kristy Berry, Ashley Nguyen, Ashleigh Neese, Charles Wood, Bing Zhu, Joel Andrews, Ashley S. Lindsey, Tyler Mattox, Antonio Ward, Silas J. Leavesley, Naga S. Annamdevula, Luciana Madeira da Silva, Alla Musiyenko, Elaine Gavin, Veronica Ramirez-Alcantara, Jacob Valiyaveettil, Xi Chen, Wen-Chi L. Chang, Kevin J. Lee
Eadie-Hofstee plot of data from Fig. 2C. Error bars = SEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203c09731c657bc4cfceaff14180d28e
https://doi.org/10.1158/1940-6207.22533277
https://doi.org/10.1158/1940-6207.22533277