Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yuko Yamakoshi"'
Autor:
Kenichiro Kataoka, Hiroaki Makino, Keiichiro Imaizumi, Brad Sherborne, Gen Unoki, Donald James Simpson, Naotaka Suzuki, C. John Harris, Richard K. Gordon, Tomomi Kosugi, Vicky Cunliffe, Heidi Kalloo-Hosein, Dale Robert Mitchell, Peter S Thomas, Kanji Komatsu, Midori Takimoto-Kamimura, Sugiura Satoshi, Mika Kambe, Yuri Sakai, Shinji Kobayashi, Aiko Fujino, Gita Patel, Yuko Yamakoshi, Julie A. Frearson, Oue Yasuhiro, Takenouchi Osami, Imai Minoru, Joelle Le, Yohei Matsueda
Publikováno v:
Journal of Medicinal Chemistry. 55:6700-6715
A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0728626099c0f201fdffc260a93476
https://doi.org/10.1021/jm300411k
https://doi.org/10.1021/jm300411k
Autor:
Toshimasa Yamauchi, Hiroshi Fukasawa, Yuko Yamakoshi, Hironori Waki, Hiroyuki Kagechika, Koichi Shudo, Takashi Kadowaki
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:1268-1271
A sensitive HPLC method for simultaneous determination of endogenous levels of all-trans-(ATRA), 13-cis-(13cRA), and 9-cis-retinoic acids (9cRA) was applied to serum samples from healthy volunteers and type II diabetes mellitus patients. Levels of 9c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a0d2642959164545e9145c6db8342b
https://doi.org/10.1248/bpb.25.1268
https://doi.org/10.1248/bpb.25.1268
Autor:
Yasuyuki Endo, Hiroshi Fukasawa, Masaki Inada, Akiko Itai, Toru Iijima, Chisato Miyaura, Yuko Yamakoshi, Asako Kubo
Publikováno v:
Chemistry & Biology. 8:341-355
Background: Carboranes (dicarba- closo -dodecaboranes) are a class of carbon-containing polyhedral boron-cluster compounds having remarkable thermal stability and exceptional hydrophobicity. Applications of the unique structural and chemical properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db26b767c65deb3549a08a6ed9edc144
https://doi.org/10.1016/s1074-5521(01)00016-3
https://doi.org/10.1016/s1074-5521(01)00016-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3313-3318
Dicarba-closo-dodecaboranes (carboranes), which have spherical geometry and hydrophobicity, are applicable as a hydrophobic pharmacophore of biologically active molecules. We have investigated structure-activity relations based on the structure of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d422d56c54f08c31ef3510bd7bc8bbde
https://doi.org/10.1016/s0960-894x(99)00596-x
https://doi.org/10.1016/s0960-894x(99)00596-x
Publikováno v:
ChemInform. 31
We have designed and synthesized estrogen antagonists bearing dicarba-closo-dodecaborane (carborane) as a hydrophobic pharmacophore based on the structure of 1-(4-hydroxyphenyl)-1,12-dicarba-closo-dodecaborane, a potent estrogen agonist that we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ba9fb03932d3114e1c39e49d88c11b9
https://doi.org/10.1002/chin.200029215
https://doi.org/10.1002/chin.200029215
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:312-314
We have designed and synthesized estrogen antagonists bearing dicarba-closo-dodecaborane (carborane) as a hydrophobic pharmacophore based on the structure of 1-(4-hydroxyphenyl)-1,12-dicarba-closo-dodecaborane, a potent estrogen agonist that we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57c9655aa280a78d3649777e9904b30
https://doi.org/10.1248/cpb.48.312
https://doi.org/10.1248/cpb.48.312
Autor:
Tomomi Kosugi, Dale R. Mitchell, Aiko Fujino, Minoru Imai, Mika Kambe, Shinji Kobayashi, Hiroaki Makino, Yohei Matsueda, Yasuhiro Oue, Kanji Komatsu, Keiichiro Imaizumi, Yuri Sakai, Satoshi Sugiura, Osami Takenouchi, Gen Unoki, Yuko Yamakoshi, Vicky Cunliffe, Julie Frearson, Richard Gordon, C. John Harris, Heidi Kalloo-Hosein, Joelle Le, Gita Patel, Donald J. Simpson, Brad Sherborne, Peter S. Thomas, Naotaka Suzuki, Midori Takimoto-Kamimura, Ken-ichiro Kataoka
Publikováno v:
Journal of Medicinal Chemistry. 55:10312-10313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fa908608094bc989344374dab7672b7
https://doi.org/10.1021/jm3013954
https://doi.org/10.1021/jm3013954
Publikováno v:
Biologicalpharmaceutical bulletin. 23(2)
The ability of certain chemicals to mimic the effects of natural steroid hormones and their potential to disrupt the delicate balance of the endocrine system in animals has attracted much interest in recent years. Alkylphenolic chemicals have been re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626b80e15a8b848642dadb612cc5b6e2
https://pubmed.ncbi.nlm.nih.gov/10706398
https://pubmed.ncbi.nlm.nih.gov/10706398
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(24)
Dicarba- closo -dodecaboranes (carboranes), which have spherical geometry and hydrophobicity, are applicable as a hydrophobic pharmacophore of biologically active molecules. We have designed and synthesized estrogenic antagonists based on the structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27088a2a73b6a775182d843b698c96ec
https://pubmed.ncbi.nlm.nih.gov/10617077
https://pubmed.ncbi.nlm.nih.gov/10617077
Autor:
Koichi Shudo, Toru Iijima, Yuko Yamakoshi, Hiroshi Fukasawa, Mitsuhiro Yamaguchi, Yasuyuki Endo
Publikováno v:
Journal of medicinal chemistry. 42(9)
We have designed and synthesized estrogen antagonists bearing dicarba-closo-dodecaborane (carborane) as a hydrophobic pharmacophore based on the structure of 1-(4-hydroxyphenyl)1,12-dicarba-closo-dodecaborane, a potent estrogen agonist that we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba40cb184ae09e8180389069926ceab
https://pubmed.ncbi.nlm.nih.gov/10229620
https://pubmed.ncbi.nlm.nih.gov/10229620