Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Yuko Yamaguchi-Iwai"'
Publikováno v:
Molecular and cellular biology. 32(24):4998-5008
Aft1p is an iron-responsive transcriptional activator that plays a central role in the regulation of iron metabolism in Saccharomyces cerevisiae. Aft1p is regulated by accelerated nuclear export in the presence of iron, mediated by Msn5p. However, th
Autor:
Takeshi Asano, Fuyuki Ishikawa, Masaaki Komatsu, Noboru Mizushima, Yuko Yamaguchi-Iwai, Kazuhiro Iwai
Publikováno v:
Molecular and Cellular Biology. 31:2040-2052
Ferritin is a cytosolic protein that stores excess iron, thereby protecting cells from iron toxicity. Ferritin-stored iron is believed to be utilized when cells become iron deficient; however, the mechanisms underlying the extraction of iron from fer
Autor:
Hitoshi Migaki, Katsuzumi Okumura, Kaori Ishihara, Tomohiro Yamazaki, Ayako Fukunaka, Taiho Kambe, Seiji Masuda, Naoko Fujiwara, Yuko Yamaguchi-Iwai, Yayoi Kurokawa, Masaya Nagao, Tomoyuki Suzuki
Publikováno v:
Journal of Biological Chemistry. 284:30798-30806
The majority of CDF/ZnT zinc transporters form homo-oligomers. However, ZnT5, ZnT6, and their orthologues form hetero-oligomers in the early secretory pathway where they load zinc onto zinc-requiring enzymes and maintain secretory pathway functions.
Autor:
Yuko Yamaguchi-Iwai, Tomoyuki Suzuki, Taiho Kambe, Kaori Ishihara, Masaya Nagao, Hitoshi Migaki, Kengo Ishihara
Publikováno v:
Journal of Biological Chemistry. 280:30956-30962
Zinc is an essential component for the catalytic activity of numerous zinc-requiring enzymes. However, until recently little has been known about the molecules involved in the pathways required for supplying zinc to these enzymes. We showed recently
Autor:
Masaya Nagao, Atsushi Kohda, Hitoshi Migaki, Katsuzumi Okumura, Kaori Ishihara, Yuko Yamaguchi-Iwai, Tomoyuki Suzuki, Wataru Matsuura, Taiho Kambe
Publikováno v:
Journal of Biological Chemistry. 280:637-643
Numerous proteins are properly folded by binding with zinc during their itinerary in the biosynthetic-secretory pathway. Several transporters have been implicated in the zinc entry into secretory compartments from cytosol, but their precise roles are
Publikováno v:
Cellular and Molecular Life Sciences (CMLS). 61:49-68
In recent years, a number of mammalian zinc transporters have been identified, and candidate genes are rapidly growing. These transporters are classified into two families: ZIP (ZRT, IRT-like protein) and CDF (cation diffusion facilitator). ZIP membe
Publikováno v:
Journal of Biological Chemistry. 278:50120-50127
In Saccharomyces cerevisiae, the iron-responsive transcription factor Aft1p plays a critical role in maintaining iron homeostasis. The activity of Aft1p is induced in response to iron starvation and as a consequence the expression of the iron-regulon
Autor:
Annette Pollington, Shulamit Jaron, Charles A. Galea, Robert J. Crisp, Yuko Yamaguchi-Iwai, Jerry Kaplan
Publikováno v:
Journal of Biological Chemistry. 278:45499-45506
Yeast are capable of modifying their metabolism in response to environmental changes. We investigated the activity of the oxygen-dependent high-affinity iron uptake system of Saccharomyces cerevisiae under conditions of heme depletion. We found that
Autor:
Toshihiko Iwanaga, Ryuzo Sasaki, Koshi Mori, Naomi Sugiura, Taiho Kambe, Yuko Yamaguchi-Iwai, Masaya Nagao, Junko Hirose, Tatsuaki Amano, Hiroshi Narita
Publikováno v:
Journal of Biological Chemistry. 277:19049-19055
Intracellular homeostasis for zinc is achieved through the coordinate regulation of specific transporters engaged in zinc influx, efflux, and intracellular compartmentalization. We have identified a novel mammalian zinc transporter, zinc transporter
Publikováno v:
Journal of Biological Chemistry. 277:18914-18918
The Aft1 transcription factor regulates the iron regulon in response to iron availability in Saccharomyces cerevisiae. Aft1 activates a battery of genes required for iron uptake under iron-starved conditions, whereas Aft1 function is inactivated unde