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pro vyhledávání: '"Yuko Tashiro-Hashimoto"'
Immunological Detection of Phosphotyrosine-Containing Proteins in Rat Livers After Insulin Injection
Autor:
Kazuyuki Tobe, Yuko Tashiro-Hashimoto, Yasuo Akanuma, Masato Kasuga, Osamu Koshio, Fumimaro Takaku
Publikováno v:
Diabetes. 39:528-533
Tyrosine-phosphorylated proteins in Triton X-100–solubilized fractions of rat livers were examined by immunoblotting with anti-phosphotyrosine antibodies. After 2 min of insulin injection via the portal vein into livers, three major bands of 170,00
Autor:
K Momomura, Yuko Tashiro-Hashimoto, Masato Kasuga, Teruo Shiba, Takashi Kadowaki, Tetsuro Izumi, Kazuyuki Tobe
Publikováno v:
Diabetes Care. 13:317-326
Several studies suggest that the tyrosine-specific protein kinase activity of the β-subunit of the insulin receptor is necessary to mediate the biological effects of insulin. This conclusion leads to the hypothesis that the effect of insulin is medi
Autor:
Kazuyuki Tobe, Masato Kasuga, Sumiko Takayama-Hasumi, K Momomura, Yasuo Akanuma, Osamu Koshio, Yukimasa Hirata, Fumimaro Takaku, Yuko Tashiro-Hashimoto
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 68:787-795
The immunoglobulin G (IgG) fraction obtained from the serum of a patient (B-10) with type B insulin resistance and acanthosis nigricans stimulated both glucose oxidation in rat adipocytes and autophosphorylation of tyrosine residues in the beta-subun