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Autor:
Bruce J. Aungst, Masako Oda, Yasushi Takahashi, Mikako Kobayashi, Yuko Saikachi, Yoshimitsu Yuhki, Michiko Yamaguchi, Hiroshi Saitoh, Koji Tadano, Kazuhito Achiwa
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 28(1-2)
The significance of intestinal P-glycoprotein (P-gp) in determining the oral bioavailability of tacrolimus has been still controversial. In this study, we reevaluated the interaction of tacrolimus with P-gp in the rat small intestine, by evaluating i