Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yuko P. Y. Lam"'
Autor:
Anisha Haris, Yuko P. Y. Lam, Christopher A. Wootton, Alina Theisen, Bryan P. Marzullo, Pascal Schorr, Dietrich A. Volmer, Peter B. O’Connor
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33:1022-1030
Autor:
Alina Theisen, Christopher A. Wootton, Anisha Haris, Tomos E. Morgan, Yuko P. Y. Lam, Mark P. Barrow, Peter B. O’Connor
Publikováno v:
Analytical chemistry. 94(45)
Ultraviolet photodissociation is a fast, photon-mediated fragmentation method that yields high sequence coverage and informative cleavages of biomolecules. In this work, 193 nm UVPD was coupled with a 12 Tesla FT-ICR mass spectrometer and 10.6 μm in
Autor:
Anisha, Haris, Yuko P Y, Lam, Christopher A, Wootton, Alina, Theisen, Bryan P, Marzullo, Pascal, Schorr, Dietrich A, Volmer, Peter B, O'Connor
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33(6)
Vitamin D compounds are a group of secosteroids derived from cholesterol that are vital for maintaining bone health in humans. Recent studies have shown extraskeletal effects of vitamin D, involving vitamin D metabolites such as the dihydroxylated vi
Autor:
Dario R. Alessi, Amir R. Khan, Yuko P. Y. Lam, Pawel Lis, Dieter Waschbüsch, Kerryn Berndsen, Axel Knebel
Publikováno v:
EMBO Reports
LRRK2 serine/threonine kinase is associated with inherited Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their switch 2 motif to control their interactions with effectors. Recent work has shown that the metal‐dependent
Autor:
Frederik Lermyte, Peter B. O’Connor, Peter J. Sadler, Joanna F. Collingwood, Mark P. Barrow, Jake Brooks, Neil D. Telling, Yuko P. Y. Lam, Christopher A. Wootton, James Everett
Publikováno v:
Journal of the American Society for Mass Spectrometry
Native top-down mass spectrometry is a fast, robust biophysical technique that can provide molecular-scale information on the interaction between proteins or peptides and ligands, including metal cations. Here we have analyzed complexes of the full-l
Autor:
Christian Rolando, Maria A. van Agthoven, Peter B. O’Connor, Marc-André Delsuc, Yuko P. Y. Lam
Publikováno v:
European Biophysics Journal
European Biophysics Journal, Springer Verlag (Germany), 2019, 48 (3), pp.213-229. ⟨10.1007/s00249-019-01348-5⟩
European Biophysics Journal, 2019, 48 (3), pp.213-229. ⟨10.1007/s00249-019-01348-5⟩
European Biophysics Journal, Springer Verlag (Germany), 2019, 48 (3), pp.213-229. ⟨10.1007/s00249-019-01348-5⟩
European Biophysics Journal, 2019, 48 (3), pp.213-229. ⟨10.1007/s00249-019-01348-5⟩
International audience; Fourier transform ion cyclotron resonance mass analysers (FT-ICR MS) can offer the highest resolutions and mass accuracies in mass spectrometry. Mass spectra acquired in an FT-ICR MS can yield accurate elemental compositions o
Autor:
Peter J. Sadler, Cookson K. C. Chiu, Yuko P. Y. Lam, Peter B. O’Connor, Christopher A. Wootton, Mark P. Barrow
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31(3)
The OsII arene anticancer complex [(η6-bip)Os(en)Cl]+ (Os1-Cl; where bip = biphenyl and en = ethylenediamine) binds strongly to DNA1 and biomolecules. Here we investigate the interaction between Os1-Cl and the model protein, BSA, using ultrahigh res
Autor:
Ian Hands-Portman, Cookson K. C. Chiu, Yuko P. Y. Lam, Frederik Lermyte, Juan Wei, Christopher A. Wootton, Isolda Romero-Canelón, Mark P. Barrow, Peter B. O’Connor
Publikováno v:
Journal of the American Society for Mass Spectrometry
Amyloid fibril formation is a hallmark in a range of human diseases. Analysis of the molecular details of amyloid aggregation, however, is limited by the difficulties in solubilizing, separating, and identifying the aggregated biomolecules. Additiona
Autor:
Peter B. O′ Connor, Matthew Willetts, Yuko P. Y. Lam, Christopher A. Wootton, Maria A. van Agthoven, Peter J. Sadler, Mark P. Barrow
Publikováno v:
The Analyst. 142:2029-2037
Transition metal-containing proteins and enzymes are critical for the maintenance of cellular function and metal-based (metallo)drugs are commonly used for the treatment of many diseases, such as cancer. Detection and characterisation of metallodrug
Autor:
Yan Guo, Chen Chen, Shipra Malhotra, Nan Bai, Peter B. O’Connor, Qiong Wu, Wei Li, Dianwen Zhang, Peng Chen, Hongzheng Fu, Yuko P. Y. Lam, Meng Li
Publikováno v:
European journal of medicinal chemistry. 183
Thrombosis is a pathological coagulation process and can lead to many serious thrombotic diseases. Here, we report a novel potent antithrombotic compound (6k) based on isosteviol with anticoagulant and antiplatelet activities. 6k selectively inhibite