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Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold

Autor: Fumiyasu Okazaki, Kenyu Yoshida, Yuko Natsui, Masatomo Iwao, Fumito Ishibashi, Masahiro Fujimoto, Hideto To, Tsutomu Fukuda, Yusuke Nanjo

Publikováno v: Bioorganic & Medicinal Chemistry. 27(2):265-277

A new class of topoisomerase I inhibitors containing the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one (abbreviated as BBPI) ring system have been developed based on structure-activity relationship studies of the cytotoxic marine alkalo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e096189e6a8192eb7ce2286eb05572a5
http://hdl.handle.net/10069/38935

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Protein Supplementation Enhances the Effects of Intermittent Loading on Skeletal Muscles by Activating the mTORC1 Signaling Pathway in a Rat Model of Disuse Atrophy

Autor: Sho Miyatake, Satoshi Fujita, Kazuo Hino, Goro Ebisu, Yuko Natsui

Publikováno v: Nutrients, Vol 12, Iss 2729, p 2729 (2020)
Nutrients
Volume 12
Issue 9

Inactivity leads to skeletal muscle atrophy, whereas intermittent loading (IL) during hind limb unloading (HU) attenuates muscle atrophy. However, the combined effects of IL and protein supplementation on disuse muscle atrophy are unclear. Therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9373cdeb11e8cccdfe45e4c2a66f0f7e
https://doi.org/10.3390/nu12092729

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