Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Yuko Maejima"'
Autor:
Yoshio Iguchi, Ryoji Fukabori, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Yuko Maejima, Kenju Shimomura, Hiroshi Mizuma, Aya Mawatari, Hisashi Doi, Yilong Cui, Hirotaka Onoe, Keigo Hikishima, Makoto Osanai, Takuma Nishijo, Toshihiko Momiyama, Richard Benton, Kazuto Kobayashi
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Chemogenetic approaches employing ligand-gated ion channels are advantageous regarding manipulation of target neuronal population functions independently of endogenous second messenger pathways. Among them, Ionotropic Receptor (IR)-mediated
Externí odkaz:
https://doaj.org/article/4f053390d6844f59b01dae87a7a16116
Autor:
Naoya Murao, Risa Morikawa, Yusuke Seino, Kenju Shimomura, Yuko Maejima, Yuichiro Yamada, Atsushi Suzuki
Publikováno v:
Physiological Reports, Vol 12, Iss 11, Pp n/a-n/a (2024)
Abstract Sildenafil, a phosphodiesterase‐5 (PDE5) inhibitor, has been shown to improve insulin sensitivity in animal models and prediabetic patients. However, its other metabolic effects remain poorly investigated. This study examines the impact of
Externí odkaz:
https://doaj.org/article/86a48398f7844fd6ad7e27a1443e3bd5
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
ObjectiveAromatherapy is a holistic healing method to promote health and well-being by using natural plant extracts. However, its precise mechanism of action and influence on the endocrine system remains unclear. Since recent studies reported that a
Externí odkaz:
https://doaj.org/article/a6fa669c8e4346008c865963cff741ef
Autor:
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shingen Misaka, Tomoyuki Ono, Hiroaki Oizumi, Keita Mizuno, Shizu Hidema, Katsuhiko Nishimori, Masato Aoyama, Heidi de Wet, Kenju Shimomura
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
The high prevalence of obesity has become a pressing global public health problem and there exists a strong association between increased BMI and mortality at a BMI of 25 kg/m2 or higher. The prevalence of obesity is higher among middle-aged adults t
Externí odkaz:
https://doaj.org/article/188f3a3a00b84739acde88f84d0b71f7
Autor:
Shigeki Kitamura, Naoya Murao, Shoko Yokota, Masaru Shimizu, Tomoyuki Ono, Yusuke Seino, Atsushi Suzuki, Yuko Maejima, Kenju Shimomura
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Objective Insulin secretion is regulated by ATP-sensitive potassium (KATP) channels in pancreatic beta-cells. Peroxisome proliferator-activated receptors (PPAR) α ligands are clinically used to treat dyslipidemia. A PPARα ligand, fenofibra
Externí odkaz:
https://doaj.org/article/16b4b294cf154b6cb024b62b129c2711
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
ObjectiveCheckpoint inhibitors (CPIs) can trigger complications related to the autoimmune process such as CPI-triggered diabetes mellitus. The typical treatment for CPI-triggered diabetes is insulin, but a detailed therapeutic method has not yet been
Externí odkaz:
https://doaj.org/article/7df53643dc4b475084a17fd68d037c20
Autor:
Hiroshi Ogata, Shigeki Kitamura, Makoto Fujiwara, Masaru Shimizu, Chengbo Tan, Songji Zhao, Yuko Maejima, Kenju Shimomura
Publikováno v:
Dose-Response, Vol 21 (2023)
Sulfamethoxazole (SMX) is widely used as an antibiotic in the clinical application with side effects of hypoglycemia. This is because SMX contains the sulfonamide structure, which closes ATP-sensitive potassium (K ATP ) channels and induces insulin s
Externí odkaz:
https://doaj.org/article/fe05354e2280460a8227d748e50d6cf3
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract Objectives Due to the increase of type 2 diabetes (T2D), the number of patients in treatment with multiple anti-diabetic agents is increased. According to the recent recommendation of treatment guidelines, sodium-glucose cotransporter 2 (SGL
Externí odkaz:
https://doaj.org/article/234d8ac6a58d434491dd260102086da1
Autor:
Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Yuko Maejima, Shingen Misaka, Kenju Shimomura, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Burn injury is the leading cause of death and disability worldwide and places a tremendous economic burden on society. Systemic inflammatory responses induced by thermal burn injury can cause muscle wasting, a severe involuntary loss of skeletal musc
Externí odkaz:
https://doaj.org/article/84b5aa88386741d1bbdd4f00d2ee49ad
Autor:
Yuko Maejima, Shoko Yokota, Masaru Shimizu, Shoichiro Horita, Daisuke Kobayashi, Akihiro Hazama, Kenju Shimomura
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Feeding rhythm disruption contributes to the development of obesity. The receptors of glucagon-like peptide-1 (GLP-1) are distributed in the wide regions of the brain. Among these regions, GLP-1 receptors (GLP-1R) are expressed in
Externí odkaz:
https://doaj.org/article/e2c9447372424a83bcc795d655f055d1