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Lidocaine Disrupts Axonal Membrane of Rat Sciatic Nerve In Vitro

Autor: Hiroshi Katsuki, Yuko Kanai, Mayumi Takasaki

Publikováno v: Anesthesia & Analgesia. 91:944-948

UNLABELLED Highly concentrated lidocaine has been reported to induce irreversible loss of membrane potential in crayfish nerve, which implies membrane disruption as one of the direct mechanisms of lidocaine-induced neurotoxicity. To confirm lidocaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4432320e41a22438369ddeb31ed9df5b
https://doi.org/10.1097/00000539-200010000-00033

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Comparisons of the Anesthetic Potency and Intracellular Concentrations of S(−) and R() Bupivacaine and Ropivacaine in Crayfish Giant Axon in Vitro

Autor: Hiroshi Katsuki, Yuko Kanai, Mayumi Takasaki

Publikováno v: Anesthesia & Analgesia. 90:415-420

UNLABELLED Levobupivacaine and ropivacaine are both single S(-) enantiomers that have less severe cardiotoxic and convulsant effects than racemic bupivacaine. We compared the anesthetic actions of S(-) bupivacaine, R(+) bupivacaine, and ropivacaine i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd644e209fa1893b3e5392c35d72e9f2
https://doi.org/10.1213/00000539-200002000-00032

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Effects of levobupivacaine, bupivacaine, and ropivacaine on tail-flick response and motor function in rats following epidural or intrathecal administration1

Autor: Yuko Kanai, Toshiharu Kasaba, Tadashi Nakamura, Mayumi Takasaki, Shingo Tateyama

Publikováno v: Regional Anesthesia and Pain Medicine. 24:444-452

Background and Objectives Commercially available bupivacaine is a racemic mixture of S(−)-and R(+)-enantiomers. Although the S(−)-enantiomers levobupivacaine and ropivacaine are less toxic to the cardiovascular and central nervous systems than bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80f0458642cbaa9a393d027d47c447f8
https://doi.org/10.1016/s1098-7339(99)90012-3

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Low Wilms' tumor gene expression in tumor tissues predicts poor prognosis in patients with non-small-cell lung cancer

Autor: Haruo Sugiyama, Tomoya Kawaguchi, Seiji Hayashi, Masanori Kitaichi, Yuko Kanai, Tomoaki Teramoto, Akihide Matsumura, Yusuke Oji, Masaji Okada

Publikováno v: Cancer investigation. 30(2)

We elucidated the relationship between prognosis of non-small-cell lung cancer (NSCLC) and Wilms’ tumor gene (WT1) mRNA expression in tumor tissue. The WT1 mRNA expression levels of the fatal cases were lower as compared with those of the survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b378784f62dc81a38cca3cea4637a1f
https://pubmed.ncbi.nlm.nih.gov/22148937

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Security Management and Quality Control at Our ART Laboratory

Autor: Yuko Kanai

Publikováno v: Journal of Mammalian Ova Research. 26:227-228

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6946a5d3569b7e7cdbfbec35c6e91aa8
https://doi.org/10.1274/jmor.26.227

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Graded, irreversible changes in crayfish giant axon as manifestations of lidocaine neurotoxicity in vitro

Autor: Hiroshi Katsuki, Yuko Kanai, Mayumi Takasaki

Publikováno v: Anesthesia and analgesia. 86(3)

High concentrations of lidocaine induce irreversible conduction block with little effect on resting membrane potential (Em). We assumed the mechanism of persistent neurologic deficit caused by local anesthetics may result from neural death, as repres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93d2e89392aea88927e8324e22dde9e
https://pubmed.ncbi.nlm.nih.gov/9495417

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Lidocaine disrupts axonal membrane of rat sciatic nerve in vitro. (Miyazaki Medical College, Miyazaki, Japan) Anesth Analg 2000;91:944-948

Autor: Mayumi Takasaki, Hiroshi Katsuki, Yuko Kanai

Publikováno v: Pain Practice. 1:201-201

To confirm lidocaine-induced membrane disruption in mammalian nerve, this study measured a lactate dehydrogenase (LDH) leakage from rat sciatic nerve in vitro. Before applying lidocaine, the desheathed nerve was incubated for 60 min in Krebs-Ringer s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebd1c6a9ae8044baf18e62ce9b27855e
https://doi.org/10.1046/j.1533-2500.2001.01023-6.x

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