Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Yuko Fujiwara"'
Autor:
Elisa Manieri, Guodong Tie, Ermanno Malagola, Davide Seruggia, Shariq Madha, Adrianna Maglieri, Kun Huang, Yuko Fujiwara, Kevin Zhang, Stuart H. Orkin, Timothy C. Wang, Ruiyang He, Neil McCarthy, Ramesh A. Shivdasani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract PDGFRA-expressing mesenchyme supports intestinal stem cells. Stomach epithelia have related niche dependencies, but their enabling mesenchymal cell populations are unknown, in part because previous studies pooled the gastric antrum and corpu
Externí odkaz:
https://doaj.org/article/92ebc7cc83f44ff5aa700ded18055634
Autor:
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells. In particul
Externí odkaz:
https://doaj.org/article/304ef5b1eb3c4a3ab19d3dd9ace1fed9
Autor:
Tsunetaka Kijima, Akira Matsushita, Kenju Akai, Tsuyoshi Hamano, Satoshi Takahashi, Kazushige Fujiwara, Yuko Fujiwara, Makoto Sato, Toru Nabika, Kristina Sundquist, Jan Sundquist, Yutaka Ishibashi, Shunichi Kumakura
Publikováno v:
BMC Health Services Research, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background This study aimed to explore associations between various elements of primary care, patient satisfaction, and loyalty. Methods This cross-sectional study used a modified version of the Primary Care Assessment Tool (PCAT), which was
Externí odkaz:
https://doaj.org/article/87460353c6894ddba223fe11f9b314c9
Autor:
Kotaro Hama, Yuko Fujiwara, Tamuro Hayama, Tsuyoshi Ozawa, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi, Kazuaki Yokoyama
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Colorectal cancer (CRC) is a major cancer, and its precise diagnosis is especially important for the development of effective therapeutics. In a series of metabolome analyses, the levels of very long chain fatty acids (VLCFA) were shown to b
Externí odkaz:
https://doaj.org/article/bfb250236fb14b6cad3a33c992f59d42
Autor:
Kotaro Hama, Yuko Fujiwara, Shigeo Takashima, Yasuhiro Hayashi, Atsushi Yamashita, Nobuyuki Shimozawa, Kazuaki Yokoyama
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 4, Pp 523-536 (2020)
X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by deleterious mutations in the ABCD1 gene. The ABCD1 protein transports very long-chain FAs (VLCFAs) from the cytosol into the peroxisome where the VLCFAs are degraded through β-
Externí odkaz:
https://doaj.org/article/7195fa710b5142e4a6d2da324487dc47
Publikováno v:
Journal of Wood Science, Vol 65, Iss 1, Pp 1-11 (2019)
Abstract The strain associated with orthogonal cutting with and against the grain of hinoki (Chamaecyparis obtusa) was measured. Digital image correlation method was used to measure strain distributed in the area within 0.5 mm of the cutting edge. Th
Externí odkaz:
https://doaj.org/article/6970392024e04ce6929dac79ed00134b
Autor:
Ha-Neui Kim, Jinhu Xiong, Ryan S. MacLeod, Srividhya Iyer, Yuko Fujiwara, Keisha M. Cawley, Li Han, Yonghan He, Jeff D. Thostenson, Elisabeth Ferreira, Robert L. Jilka, Daohong Zhou, Maria Almeida, Charles A. O’Brien
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encod
Externí odkaz:
https://doaj.org/article/657c52f5dd0742dba28700a3da2de806
Autor:
Jinhu Xiong, Keisha Cawley, Marilina Piemontese, Yuko Fujiwara, Haibo Zhao, Joseph J. Goellner, Charles A. O’Brien
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.
Externí odkaz:
https://doaj.org/article/f3fdb2bc80d5499aa847b891e2ea7b50
Autor:
Yuko Fujiwara, Motonobu Saito, Ana I. Robles, Momoyo Nishida, Fumitaka Takeshita, Masatoshi Watanabe, Takahiro Ochiya, Jun Yokota, Takashi Kohno, Curtis C. Harris, Naoto Tsuchiya
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 33-48 (2018)
Background: Activation of intrinsic p53 tumor-suppressor (TS) pathways is an important principle underlying cancer chemotherapy. It is necessary to elucidate the precise regulatory mechanisms of these networks to create new treatment strategies. Meth
Externí odkaz:
https://doaj.org/article/111276e6729e4bceaecc992119f1cba7
Autor:
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Yuko Fujiwara, Takeshi Ishihara
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 115, Iss , Pp - (2019)
Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated the effect of vanillin inhalation on m
Externí odkaz:
https://doaj.org/article/0a87da6cffa14755ac1d82614428a48e