Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yukiyoshi Yamazaki"'
Autor:
Andrew K. Mlynarchik, Jose-Luiz Figueiredo, Hengmin Zhang, Ken Mizuno, Anna H. Ha, Arda Halu, Iwao Yamada, Masanori Aikawa, Lang H Lee, Yukiyoshi Yamazaki, Sasha A Singh, Naoaki Arima, Jiao Qiao, Hideyuki Higashi, Yusuke Sasaki
Publikováno v:
Journal of proteome research. 19(1)
Roux-en-Y gastric bypass (RYGB) surgery reduces weight in obese patients. A marked decrease in blood glucose levels occurs before weight loss; however, key molecules that improve the glycemic profile remain largely unknown. Using a murine RYGB surger
Autor:
Masanori Aikawa, Takashi Maejima, Yukiyoshi Yamazaki, Hideyuki Higashi, Michael O. Hottiger, Lang H Lee, Sasha A Singh
Publikováno v:
Journal of Proteome Research
ADP-ribosylation is a post-translational modification that, until recently, has remained elusive to study at the cellular level. Previously dependent on radioactive tracers to identify ADP-ribosylation targets, several advances in mass spectrometric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385a194b6b40a4997a7ee8e4cc25e552
https://www.zora.uzh.ch/id/eprint/169733/
https://www.zora.uzh.ch/id/eprint/169733/
Autor:
Florian Schlotter, Hideyuki Higashi, Elena Aikawa, Maximillian A. Rogers, Takehito Okui, Sasha A Singh, Stephanie Morgan, Lang H Lee, Lixiang Wang, Alan Daugherty, Masanori Aikawa, Masatoshi Nomura, Yukiyoshi Yamazaki, Joshua D. Hutcheson, Arda Halu, Claudia Goettsch
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38
Objective: Dysfunctional protein homeostasis (proteostasis) contributes to cardiovascular and metabolic disorders. We and others associated the mitochondrial fission protein, Dynamin-related protein 1 (DRP1) with cardiometabolic disease. Liver DRP1-d
Publikováno v:
Synthesis. 45:1319-1324
Novel synthetic methods for the production of butyl ( S )-2-hydroxybutanoate starting from butyl (2 S ,3 R )-epoxybutanoate or butyl ( S )-2,3-epoxypropanoate were established. The former method utilized the regioselective thiolysis of the epoxybutan
Publikováno v:
Tetrahedron. 64:8155-8158
A practical synthesis of optically pure PPARα agonist, (R)-K-13675, is described. This process is based on the use of (S)-2-hydroxybutyrolactone, which can be transformed into the requisite n-butyl (S)-2-hydroxybutanoate in an efficient manner. A ke
Publikováno v:
Synthesis. 2008:1017-1022
Enantioselective synthesis of enantiomerically pure PPARα agonist ( R)-K-13675 can be achieved starting from ( S)-2-hydroxybutyrolactone. An important intermediate, 2-(aryloxy)butyrolactone, was prepared by reaction of the phenol with ( S)-2-hydroxy
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:869-876
Optically active 2-hydroxymethyl-1, 4-dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2-hydroxymethyl-1, 4-dihydropyridine. On
Autor:
Hirose Yoshihiko, Yoshiyasu Terao, Yukiyoshi Yamazaki, K. Maruyama, Hirosato Ebiike, Y. Kurono, Kazuo Achiwa, I. Sasaki, Kariya Kinya
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:863-868
Chiral 4-aryl-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridinedicarboxylates and 1, 4-dihydro-2, 4, 6-trimethyl-3, 5-pyridinedicarboxylate have been obtained in 80-99%ee by lipase-catalyzed hydrolysis of bis(acyloxymethyl) 1, 4-dihydro-3, 5-pyridinedicarboxy
Publikováno v:
ChemInform. 26
The absolute configuration of 4-(2, 3-dichlorophenyl-1, 4-dihydropyridines was established by chemical correlation with (S)-(-)-felodipine, the absolute configuration of which had been determined by X-ray analysis.
Publikováno v:
ChemInform. 27
Homochiral 4-Aryl-1, 4-dihydropyridine-5-phosphate (NZ 105) was synthesized from the racemic materials. The enantioselective hydrolysis by lipase catalyst was smoothly proceeded and optically active carboxylic acid was converted into optically active