Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid

Autor: Takashi Sakurai, Kengo Ito, Koichi Kozaki, Kenji Toba, Hiroshige Fujishiro, Masanori Nakagawa, Kazuo Ogawa, Hiroshi Yamauchi, Chio Okuyama, Hiroshi Ito, Daisuke Watanabe, Satoshi Koyama, Ryosuke Takahashi, Kazunori Terasaki, Harushi Mori, Tetsuya Maeda, Masaru Suzuki, Masatoyo Nishizawa, Mikio Shoji, Mineo Yamazaki, Etsuro Matsubara, Shuichi Ikeda, Hidehiro Mizusawa, Kenji Nakashima, Jun Takeuchi, Hiroyuki Shimada, Takashi Kudo, Nobuyuki Saito, Hiroyuki Arai, Takashi Yamazaki, Mitsutoshi Okazaki, Takeshi Iwatsubo, Nobuo Sanjo, Masaki Takao, Shigeo Murayama, Masahito Yamada, Yuichi Sato, Satoshi Takahashi, Harumasa Takano, Masuhiro Sakata, Shunji Mugikura, Shun Shimohama, Takashi Kato, Toshiki Mizuno, Yukiko Yamada, Daisuke Yamamoto, Makoto Higuchi, Yu Nakamura, Yu Hayasaka, Yoshiko Fukushima, Takayuki Obata, Kimiko Yoshimaru, Shinichi Sakamoto, Kaori Watanabe, Masashi Tsujimoto, Osamu Yokota, Seishi Terada, Atsushi Watanabe, Akinori Miyashita, Ryozo Kuwano, Daisuke Yamaguchi, Tetsuaki Arai, Rieko Okada, Hiroshi Matsuda, Kyoko Ito, Kenji Ishii, Yukio Miki, Yuka Yamamoto, Toru Takahashi, Makoto Sasaki, Ken Nagata, Hajime Sato, Miwako Takahashi, Toshimitsu Momose, Isao Ito, Masakazu Yamagishi, Mayumi Watanabe, Hitoshi Shibuya, Shin-ichi Urayama, Hidenao Fukuyama, Toshio Kawamata, Yasuji Yamamoto, Kiyoshi Maeda, Manabu Ikeda, Mamoru Hashimoto, Takeshi Kawarabayashi, Masaki Ikeda, Eizo Iseki, Kazunari Ishii, Yuko Saito, Miharu Samuraki, Heii Arai, Takashi Asada, Haruo Hanyu, Katsuyoshi Mizukami, Takahiko Tokuda, Yukihiko Washimi, Mitsuhiro Yoshita, Hitoshi Shimada, Fumitoshi Niwa, Hitoshi Shinotoh, Tetsuya Suhara, Masatoshi Takeda, YOKO KONAGAYA, Takaaki Mori, Kensaku Kasuga, Takayoshi Tokutake, Takeshi Ikeuchi, Hiroaki Kazui, Noriko Sato, Takeshi Tamaru, Masanobu Takahashi, Yasuhiro Nakata, Yasumasa Yoshiyama, Hisatomo Kowa, Shuichi Ono, Takuya Ohkubo, Yasuo Kuwabara, Tomoko Nakazawa, Kazutomi Kanemaru, Toshiaki Taoka, Nobuyuki Okamura, Hiroki Hayashi, Shin Tanaka, Kayoko Kikuchi, Masataka Kikuchi, Tamao Tsukie, Kazushi Suzuki, Ryoko Ihara, Atsushi Iwata, Norikazu Hara, Morihiro Sugishita, Michio Senda, Masaki Saitoh, Rika Yamauchi, Takashi Hayashi, Seiju Kobayashi, Norihito Nakano, Junichiro Kanazawa, Takeshi Ando, Chiyoko Takanami, Masato Hareyama, Masamitsu Hatakenaka, Eriko Tsukamoto, Shinji Ochi, Yasuhito Wakasaya, Takashi Nakata, Naoko Nakahata, Yoshihiro Takai, Hisashi Yonezawa, Junko Takahashi, Masako Kudoh, Yutaka Matsumura, Yohsuke Hirata, Tsuyoshi Metoki, Susumu Hayakawa, Masayuki Takeda, Toshiaki Sasaki, Koichiro Sera, Yoshihiro Saitoh, Shoko Goto, Kuniko Ueno, Hiromi Sakashita, Kuniko Watanabe, Yasushi Kondoh, Daiki Takano, Mio Miyata, Hiromi Komatsu, Tomomi Sinoda, Rena Muraoka, Hitomi Ito, Aki Sato, Toshibumi Kinoshita, Hideyo Toyoshima, Kaoru Sato, Shigeki Sugawara, Fumiko Kumagai, Katsutoshi Furukawa, Masaaki Waragai, Naoki Tomita, Mari Ootsuki, Katsumi Sugawara, Satomi Sugawara, Atsushi Umetsu, Takanori Murata, Tatsuo Nagasaka, Yukitsuka Kudo, Manabu Tashiro, Shoichi Watanuki, Saeri Ishikawa, Emiko Kishida, Nozomi Sato, Mieko Hagiwara, Kumi Yamanaka, Takeyuki Watanabe, Taeko Takasugi, Shoichi Inagawa, Kenichi Naito, Masanori Awaji, Tsutomu Kanazawa, Kouiti Okamoto, Tsuneo Yamazaki, Yuiti Tasiro, Syunn Nagamine, Shiori Katsuyama, Sathiko Kurose, Sayuri Fukushima, Etsuko Koya, Makoto Amanuma, Noboru Oriuti, Kouiti Ujita, Kazuhiro Kishi, Kazuhisa Tuda, Etsuko Nakajima, Katsumi Miyamoto, Kousaku Saotome, Tomoya Kobayashi, Saori Itoya, Jun Ookubo, Toshiya Akatsu, Yoshiko Anzai, Junya Ikegaki, Yuuichi Katou, Kaori Kimura, Ryou Kuchii, Hajime Saitou, Kazuya Shinoda, Satoka Someya, Hiroko Taguchi, Kazuya Tashiro, Masaya Tanaka, Tatsuya Nemoto, Ryou Wakabayashi, Hitoshi Shinoto, Kazuko Suzuki, Izumi Izumida, Katsuyuki Tanimoto, Takahiro Shiraishi, Junko Shiba, Hiroaki Yano, Miki Satake, Aimi Nakui, Yae Ebihara, Tomomi Hasegawa, Mami Kato, Yuki Ogata, Hiroyuki Fujikawa, Nobuo Araki, Yoshihiko Nakazato, Takahiro Sasaki, Tomokazu Shimadu, Etsuko Imabayashi, Asako Yasuda, Etuko Yamamoto, Natsumi Nakamata, Noriko Miyauchi, Keiko Ozawa, Rieko Hashimoto, Taishi Unezawa, Takafumi Ichikawa, Tunemichi Mihara, Masaya Hirano, Shinichi Watanabe, Junichiro Fukuhara, Hajime Matsudo, Toshihiro Hayashi, Toji Miyagawa, Mizuho Yoshida, Yuri Koide, Eriko Samura, Kurumi Fujii, Nagae Orihara, Akira Kunimatsu, Takuya Arai, Yoshiki Kojima, Masami Goto, Takeo Sarashina, Syuichi Uzuki, Seiji Katou, Yoshiharu Sekine, Yukihiro Takauchi, Chiine Kagami, Yasushi Nishina, Maria Sakaibara, Yumiko Okazaki, Maki Obata, Yuko Iwata, Mizuho Minami, Yasuko Hanabusa, Hanae Shingyouji, Kyoko Tottori, Aya Tokumaru, Makoto Ichinose, Kazuya Kume, Syunsuke Kahashi, Kunimasa Arima, Tadashi Tukamoto, Yuko Nagahusa, Maki Yamada, Tiine Kodama, Tomoko Takeuchi, Keiichiro Ozawa, Yoshiko Kawaji, Kyouko Tottori, Satoshi Sawada, Makoto Mimatsu, Daisuke Nakkamura, Shunichirou Horiuchi, Tsuneyoshi Ota, Aiko Kodaka, Yuko Tagata, Tomoko Nakada, Kiyoshi Sato, Norio Murayama, Satoshi Kimura, Hirofumi Sakurai, Takahiko Umahara, Hidekazu Kanetaka, Kaori Arashino, Mikako Murakami, Ai Kito, Seiko Miyagi, Kaori Doi, Kazuyoshi Sasaki, Akiko Ishiwata, Yasushi Arai, Akane Nogami, Sumiko Fukuda, Sayaka Kimura, Ayako Machida, Kuninori Kobayashi, Mutsufusa Watanabe, Hiromi Utashiro, Yukiko Matsumoto, Kumiko Hagiya, Yoshiko Miyama, Takako Shinozaki, Haruko Hiraki, Isamu Ohashi, Akira Toriihara, Shinichi Ohtani, Toshifumi Matsui, Tomomi Toyama, Hideki Sakurai, Kumiko Sugiura, Hirofumi Taguchi, Shizuo Hatashita, Akari Imuta, Akiko Matsudo, Daichi Wakebe, Hideki Hayakawa, Mitsuhiro Ono, Takayoshi Ohara, Yutaka Arahata, Akinori Takeda, Akiko Yamaoka, Hideyuki Hattori, Miura Hisayuki, Hidetoshi Endou, Syousuke Satake, Young Jae Hong, Katsunari Iwai, Kenji Yoshiyama, Masaki Suenaga, Sumiko Morita, Teruhiko Kachi, Rina Miura, Takiko Kawai, Ai Honda, Kengo Itou, Ken Fujiwara, Rikio Katou, Mariko Koyama, Naohiko Fukaya, Akira Tsuji, Hitomi Shimizu, Hiroyuki Fujisawa, Takanori Sakata, Kenjiro Ono, Moeko Shinohara, Yuki Soshi, Kozue Niwa, Chiaki Doumoto, Mariko Hata, Miyuki Matsushita, Mai Tsukiyama, Nozomi Takeda, Sachiko Yonezawa, Ichiro Matsunari, Osamu Matsui, Fumiaki Ueda, Yasuji Ryu, Masanobu Sakamoto, Yasuomi Ouchi, Madoka Chita, Yumiko Fujita, Rika Majima, Hiromi Tsubota, Umeo Shirasawa, Masashi Sugimori, Wataru Ariya, Yuuzou Hagiwara, Yasuo Tanizaki, Hajime Takechi, Chihiro Namiki, Kengo Uemura, Takeshi Kihara, Shizuko Tanaka-Urayama, Emiko Maeda, Natsu Saito, Shiho Satomi, Konomi Kabata, Tomohisa Okada, Koichi Ishizu, Shigeto Kawase, Satoshi Fukumoto, Masaki Kondo, Yoko Oishi, Mariko Yamazaki, Yoku Asano, Chizuru Hamaguchi, Kei Yamada, Kentaro Akazawa, Shigenori Matsushima, Takamasa Matsuo, Toshiaki Nakagawa, Takeshi Nii, Takuji Nishida, Kuniaki Kiuchi, Masami Fukusumi, Hideyuki Watanabe, Akihiro Nogi, Toshihisa Tanaka, Naoyuki Sato, Masayasu Okochi, Takashi Morihara, Shinji Tagami, Noriyuki Hayashi, Masahiko Takaya, Tamiki Wada, Mikiko Yokokoji, Hiromichi Sugiyama, Shuko Takeda, Keiko Nomura, Mutsumi Tomioka, Eiichi Uchida, Yoshiyuki Ikeda, Mineto Murakami, Takami Miki, Suzuka Ataka, Motokatsu Kanemoto, Akitoshi Takeda, Rie Azuma, Yuki Iwamoto, Naomi Tagawa, Junko Masao, Yuka Matsumoto, Yuko Kikukawa, Hisako Fujii, Junko Matsumura, Susumu Shiomi, Joji Kawabe, Yoshihiro Shimonishi, Mitsuji Higashida, Tomohiro Sahara, Takashi Yamanaga, Hiroyuki Tsushima, Kazuo Sakai, Haruhiko Oda, Taichi Akisaki, Mizuho Adachi, Masako Kuranaga, Sachi Takegawa, Yoshihiko Tahara, Takeshi Ishihara, Hajime Honda, Yuki Kishimoto, Naoya Takeda, Nao Imai, Mayumi Yabe, Kentaro Ida, Daigo Anami, Seiji Inoue, Toshi Matsushita, Reiko Wada, Shinsuke Hiramatsu, Hiromi Tonbara, Reiko Yamamoto, Kenji Wada-Isoe, Saori Yamasaki, Eijiro Yamashita, Ichiro Ishikawa, Sonoko Danjo, Tomomi Shinohara, Miyuki Ueno, Yuka Kashimoto, Yoshihiro Nishiyama, Narihide Kimura, Yasuhiro Sasakawa, Takashi Ishimori, Yukito Maeda, Tatsuo Yamada, Shinji Ouma, Aika Fukuhara-Kaneumi, Nami Sakamoto, Rie Nagao, Kengo Yoshimitsu, Ryuji Nakamuta, Minoru Tanaka, Keiichirou Kaneda, Yuusuke Yatabe, Kazuki Honda, Naoko Ichimi, Fumi Akatuka, Mariko Morinaga, Miyako Noda, Mika Kitajima, Toshinori Hirai, Shinya Shiraishi, Naoji Amano, Shinsuke Washizuka, Shin Inuzuka, Tetsuya Hagiwara, Nobuhiro Sugiyama, Yatsuka Okada, Tomomi Ogihara, Takehiko Yasaki, Minori Kitayama, Tomonori Owa, Akiko Ryokawa, Rie Takeuchi, Satoe Goto, Keiko Yamauchi, Mie Ito, Tomoki Kaneko, Hitoshi Ueda, Ban Mihara, Hirofumi Kubo, Akiko Takano, Gou Yasui, Masami Akuzawa, Kaori Yamaguchi, Toshinari Odawara, Megumi Shimamura, Mikiko Sugiyama, Naomi Oota, Shigeo Takebayashi, Yoshigazu Hayakawa, Mitsuhiro Idegawa, Noriko Toya

Publikováno v: BMJ Neurology Open, Vol 4, Iss 2 (2022)

Background The AT(N) classification was proposed for categorising individuals according to biomarkers. However, AT(N) profiles may vary depending on the markers chosen and the target population.Methods We stratified 177 individuals who participated i

Externí odkaz: https://doaj.org/article/04e822095b044e74bc3e6de1406db93d

Imaging of Reactive Astrogliosis by Positron Emission Tomography

Autor: Ryuichi Harada, Shozo Furumoto, Yukitsuka Kudo, Kazuhiko Yanai, Victor L. Villemagne, Nobuyuki Okamura

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Many neurodegenerative diseases are neuropathologically characterized by neuronal loss, gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau tangles in Alzheimer’s disease (AD). In postmortem AD brains, reactiv

Externí odkaz: https://doaj.org/article/617049dc61ba4599b256e81ca1baa9ea

Orengedokuto and san'oshashinto improve memory deficits by inhibiting aging-dependent activation of glycogen synthase kinase-3β

Autor: Hironori Fujiwara, Jun Yoshida, Dya Fita Dibwe, Suresh Awale, Haruka Hoshino, Hiroshi Kohama, Hiroyuki Arai, Yukitsuka Kudo, Kinzo Matsumoto

Publikováno v: Journal of Traditional and Complementary Medicine, Vol 9, Iss 4, Pp 328-335 (2019)

Background and aim: The aging-dependent activation of glycogen synthase kinase-3β (GSK-3β) has been suggested to be important in the onset of dementia. To discover novel therapeutic Kampo medicines for dementia, we examined the effects of orengedok

Externí odkaz: https://doaj.org/article/1c0f5162801d43bc8d33961d2ac3157e

Dissociation of Tau Deposits and Brain Atrophy in Early Alzheimer’s Disease: A Combined Positron Emission Tomography/Magnetic Resonance Imaging Study

Autor: Yoko Shigemoto, Daichi Sone, Etsuko Imabayashi, Norihide Maikusa, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Noriko Sato, Hiroshi Matsuda

Publikováno v: Frontiers in Aging Neuroscience, Vol 10 (2018)

The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment of tau pathology in Alzheimer’s disease (AD). However, because PET scanners have limited spatial resolution, the measured signals of small brain str

Externí odkaz: https://doaj.org/article/f6ef7336fe78408598fee96b46a66ca5

Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography.

Autor: Aiko Ishiki, Nobuyuki Okamura, Katsutoshi Furukawa, Shozo Furumoto, Ryuichi Harada, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, Yoichi Ishikawa, Tetsuro Tago, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140311 (2015)

The formation of neurofibrillary tangles is believed to contribute to the neurodegeneration observed in Alzheimer's disease (AD). Postmortem studies have shown strong associations between the neurofibrillary pathology and both neuronal loss and the s

Externí odkaz: https://doaj.org/article/3b5140ccc7a145508e94a1f08462a7a1