Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Yukio Kita"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 11, p 1367 (2024)
Nucleic acid medicines are a highly attractive modality that act in a sequence-specific manner on target molecules. To date, 21 such products have been approved by the Food and Drug Administration. However, the development of nucleic acid medicines c
Externí odkaz:
https://doaj.org/article/716d414a46f4491fb9f3ea76834af2ab
Publikováno v:
Bioscience, biotechnology, and biochemistry. 67(10)
An efficient transformation system for the basidiomycete Coriolus hirsutus was developed. A double-auxotrophic mutant of C. hirsutus, deficient both in ornithine carbamoyltransferase (OCTase) and 3-isopropylmalate dehydrogenase (3-IPM dehydrogenase),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c12f1e4f39f94ea6bec30849250446
https://pubmed.ncbi.nlm.nih.gov/14586093
https://pubmed.ncbi.nlm.nih.gov/14586093
Publikováno v:
PeerJ, Vol 10, p e12929 (2022)
The spread of SARS-CoV-2, the causative agent for COVID-19, has led to a global and deadly pandemic. To date, few drugs have been approved for treating SARS-CoV-2 infections. In this study, a structure-based approach was adopted using the SARS-CoV-2
Externí odkaz:
https://doaj.org/article/3532092b78044d0991e3168e8662121b
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212065 (2019)
Plasmodium falciparum thymidylate kinase (PfTMK) showed structural and catalytic distinctions from the host enzyme rendering it a hopeful antiprotozoal drug target. Despite the comprehensive enzymologic, structural, inhibitory and chemical synthesis
Externí odkaz:
https://doaj.org/article/c70871c914e649bfad466e0055e553e2
Publikováno v:
Applied Sciences, Vol 10, Iss 7, p 2521 (2020)
In this study, the strengthening effects of different lamination conditions on carbon fiber reinforced polymers (CFRPs) for thin-walled storage tanks (TSTs) subjected to internal pressure under dynamic loads were experimentally investigated. A total
Externí odkaz:
https://doaj.org/article/f34643cac5e8467d8651dd40a43fe30e
Autor:
Takuto Nogimori, Koichi Ogami, Yuka Oishi, Ryoya Goda, Nao Hosoda, Yoshiaki Kitamura, Yukio Kitade, Shin-ichi Hoshino
Publikováno v:
Viruses, Vol 12, Iss 2, p 174 (2020)
The 2′-5′-oligoadenylate synthetase (OAS)/RNase L system protects hosts against pathogenic viruses through cleavage of the exogenous single-stranded RNA. In this system, an evolutionally conserved RNA quality control factor Dom34 (known as Pelota
Externí odkaz:
https://doaj.org/article/838ee9f5587e44f2bdccdbf020a55f99
Autor:
Takuhiro Yamaguchi, Yukio Kitajima, Yasuhiro Miyauchi, Kazutoshi Izawa, Masakazu Tanaka, Masatada Hirata, Yasunari Sadatsuki, Yoshihiro Ogawa
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205146 (2018)
We aimed to investigate the incidence of bleeding-related adverse events (AEs) among patients with disseminated intravascular coagulation (DIC) receiving recombinant thrombomodulin (rTM) and those receiving other DIC treatments, the incidence by type
Externí odkaz:
https://doaj.org/article/357abe3f28844b2590051fbe027886a6
Publikováno v:
JAPAN TAPPI JOURNAL. 32:541-547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dabde8ba1201691e4e04bdfb401ac119
https://doi.org/10.2524/jtappij.32.9_541
https://doi.org/10.2524/jtappij.32.9_541
Autor:
Akitoshi TAKEUCHI, Yukio KITAMURA
Publikováno v:
Journal of Advanced Mechanical Design, Systems, and Manufacturing, Vol 7, Iss 4, Pp 594-607 (2013)
In this study, a flat thrust bearing is developed by active exploiting the slip flow generated on a water-repellent surface. In order to produce a load, this bearing has a structure that generates a pressure flow by using the discontinuity of shear f
Externí odkaz:
https://doaj.org/article/fa32e85fada84deead2ad7b8375a8338
Autor:
Kosaku Hirota, Hideo Inoue, Yoshinari Sawama, Yoshifumi Maki, Yasunari Monguchi, Yukio Kitade, Kanoko Ikawa, Yusuke Iida, Hironao Sajiki
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6519-6546 (2012)
The reaction of 5-halogenouracil and uridine derivatives 1 and 7 with active methylene compounds under basic conditions produced diverse and selective C-C bond formation products by virtue of the nature of the carbanions. Three different types of rea
Externí odkaz:
https://doaj.org/article/14c2c06b12004165997f486bc07042a3