Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Yukio Hara"'
Autor:
Yuichi Kojima, Atsunori Tsuchiya, Masahiro Ogawa, Shunsuke Nojiri, Suguru Takeuchi, Takayuki Watanabe, Kenji Nakajima, Yukio Hara, Junji Yamashita, Junichi Kikuta, Masaaki Takamura, Masaru Ishii, Shuji Terai
Publikováno v:
Regenerative Therapy, Vol 11, Iss , Pp 269-281 (2019)
Background: Mesenchymal stem cells (MSCs) can be easily expanded. They can be acquired from medical waste such as adipose and umbilical cord tissues, are influenced by culturing conditions, and exert anti-inflammatory, antioxidant, anti-fibrotic, and
Externí odkaz:
https://doaj.org/article/5ea85cfe542a432b9eed67c99d7d4550
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 1, Pp 26-35 (2012)
Methylglyoxal (MGO) is a metabolite of glucose and perhaps mediates diabetes-related macrovascular complications including hypertension. In the present study, we examined if MGO accumulation affects vascular reactivity of isolated mesenteric artery f
Externí odkaz:
https://doaj.org/article/e98d2f5d0da543cd9e07d9a181ef5707
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 3, Pp 303-310 (2012)
Methylglyoxal (MGO) is a metabolite of glucose. MGO binds to and modifies arginine, lysine, and cysteine residues in proteins, which leads to formation of a variety of advanced glycation end-products (AGEs) such as argpyrimidine and Nε-(carboxyethyl
Externí odkaz:
https://doaj.org/article/94b7bdbf20bf4caa8ff68d1e332fa924
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 3, Pp 214-223 (2010)
CV-159 is a unique dihydropyridine Ca2+antagonist with an anti-calmodulin (CaM) action. A pathogenic feature of atherosclerosis is vascular inflammatory change. In the present study, we examined whether CV-159 exerts protective effects on smooth musc
Externí odkaz:
https://doaj.org/article/a5d8eacd87df495d80646b583343f3ae
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 2, Pp 176-183 (2010)
The concentration of methylglyoxal (MGO), a metabolite of glucose, increases in plasma of type II diabetic patients as well as in tissues of hypertensive rats. We have previously shown that MGO inhibited noradrenaline (NA)–induced smooth muscle con
Externí odkaz:
https://doaj.org/article/70b02144573e4b89ab416e54d3ccc897
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 2, Pp 182-191 (2010)
CV-159, a 1,4-dihydropyridine derivative, has Ca2+antagonistic and anti-calmodulin actions. An early feature of atherosclerosis is vascular endothelial inflammatory change. We examined whether CV-159 has protective effects against endothelial inflamm
Externí odkaz:
https://doaj.org/article/ec519e59106e43ec85e71ccb202ff4a7
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 4, Pp 390-398 (2010)
Abstract.: Methylglyoxal (MGO), a metabolite of glucose, accumulates in vascular tissues of a hypertensive animal. In the present study, we examined the effect of MGO on angiotensin (Ang) II–induced contraction of rat carotid artery. Treatment of c
Externí odkaz:
https://doaj.org/article/628acbc846034b27b6163bc876bbf5d0
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 2, Pp 193-200 (2009)
The present study investigated whether telmisartan, an angiotensin II type 1 receptor antagonist, has cardioprotective effects on monocrotaline-induced right ventricular (RV) remodeling in rats. Six-week-old male Wistar rats were divided into control
Externí odkaz:
https://doaj.org/article/3c440f0f47de4099bd4eb22927fb381d
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 305-310 (2009)
Methylglyoxal (MGO) is a metabolite of glucose. In addition to evidence that increased plasma MGO level is associated with diabetic vascular complications, recent studies demonstrated that MGO accumulated in vascular tissues of hypertensive animals.
Externí odkaz:
https://doaj.org/article/38e1fb608948451992dd0b9f7baee9fe
Autor:
Muneyoshi Okada, Ryuta Kikuzuki, Toshiyuki Harada, Yasutomo Hori, Hideyuki Yamawaki, Yukio Hara
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 4, Pp 487-494 (2008)
Little is known about the influence of angiotensin converting enzyme (ACE) inhibitors on matrix metalloproteinase (MMP) in right ventricular remodeling. We investigated the effect of captopril, an ACE inhibitor, on MMP-2 and MMP-9 in monocrotaline-in
Externí odkaz:
https://doaj.org/article/655146ea44504c829a4b29c87efe9822