Výsledky vyhledávání - "Yukio Aoyama"

Quantitation of Pyrrole-Imidazole Polyamide in Rat Plasma by High-Performance Liquid Chromatography Coupled with UV Detection

Autor: Tomonori Kamei, Takafumi Nagashima, Chihiro Tanaka, Hiroyuki Hayashi, Takahiko Aoyama, Noboru Fukuda, Yukio Aoyama, Hiroki Nagase, Yoshiaki Matsumoto, Takahiro Ueno

Publikováno v: Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2012 (2012)

A simple and robust method using high-performance liquid chromatography with UV detection was developed and validated for the determination of six pyrrole-imidazole (PI) polyamides (HN.49, TGF-β1f, TGF-β1t, HN.50f, HN.50t, and LOX-1) in rat plasma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4c46467bb91f00f613c41c90350e3d
https://doi.org/10.1155/2012/715928

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Synthesis and Pharmacological Evaluation of 3-Amino-1-(5-indanyloxy)-2-propanol Derivatives as Potent Sodium Channel Blockers for the Treatment of Stroke

Autor: Maki Seki, Hiroshi Shimada, Yukio Aoyama, Aki Soejima, Hikaru Nonaka, Osamu Tsuruta

Publikováno v: Chemical and Pharmaceutical Bulletin. 60:488-498

In investigating potent sodium (Na(+)) channel blockers for the treatment of ischemic stroke, we synthesized a novel series of 3-amino-1-(5-indanyloxy)-2-propanol derivatives and evaluated their inhibitory effects on neuronal Na(+) channels. The 3-am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c1f0552a657af6116c2b1f8b875a0d
https://doi.org/10.1248/cpb.60.488

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Efficacy of 1% Ropivacaine at Sacral Segments in Lumbar Epidural Anesthesia

Autor: Ohe Y, Yukio Aoyama, Masayuki Arakawa

Publikováno v: Regional Anesthesia and Pain Medicine. 28:208-214

Background and Objectives: It is suggested that the potency of 1% ropivacaine is comparable to that of 0.75% bupivacaine and higher than that of 2% lidocaine. Alkalinized lidocaine reportedly enhances the block of sacral segments during lumbar epidur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b21ee384e2a3ef6886608d008bd1f94
https://doi.org/10.1097/00115550-200305000-00007

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Epidural bolus injection with alkalinized lidocaine improves blockade of the first sacral segment — a brief report

Autor: Masayuki Arakawa, Ohe Y, Yukio Aoyama

Publikováno v: Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 49:566-570

It has been reported that the addition of epinephrine and/or bicarbonate to local anesthetic enhances the depth of epidural blockade and that initial partial bolus injection results in greater caudal spread. We evaluated the anesthetic effects of lid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb1ea1b87e01c07e928b327580055e2
https://doi.org/10.1007/bf03017382

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Efficient Synthesis of 2′-Bromo-2′-Deoxy-3′,5′-O-TPDS-pyrimidine Nucleosides by Boron Trifluoride Catalyzed Reaction of O2,2′-Anhydro-(1-β-D-Arabinofuran0Syl)pyrimidine Nucleosides with Lithium Bromide

Autor: Yoshiharu Ishido, Etsuko Kawashima, Yoshiaki Iwamoto, Takeshi Sekine, Yukio Aoyama

Publikováno v: Nucleosides and Nucleotides. 15:733-738

Efficient syntheses of 2′-bromo-2′-deoxy-3′,5′-O-TPDS-uridine (5a) and 1-(2-bromo-3,5-O-TPDS-β-D-ribofuranosyl)thymine (5b) from uridine and 1-(β-D-ribofuranosyl)thymine are described, respectively. The key step is a treatment of 3′,5′-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e5b26df27dcc5ae2177b6c0442f31e
https://doi.org/10.1080/07328319608002418

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Highly Diastereoselective Synthesis of (2'S)-[2'-2H]-2'-Deoxyribonucleosides from the Corresponding Ribonucleosides

Autor: Masayoshi Miyahara, Masatsune Kainosho, Yoshiharu Ishido, Mohamed F. Radwan, Etsuko Kawashima, Yukio Aoyama, Takeshi Sekine, Yoshimasa Kyogoku

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 14:333-336

The four (2′S)-[2′-2H]-2′-deoxynucleosides (>90 atom % 2H), were synthesized from the corresponding ribonucleosides involving six steps of reactions, i.e., oxidation of their 2′-hydroxyl group, stereoselective reductive deuteration of the res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40920d506b59754a8d988d6438ef76aa
https://doi.org/10.1080/15257779508012375

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