Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Yukio, Takamatsu"'
Autor:
Hiroko Kotajima-Murakami, Hideo Hagihara, Atsushi Sato, Yoko Hagino, Miho Tanaka, Yoshihisa Katoh, Yasumasa Nishito, Yukio Takamatsu, Shigeo Uchino, Tsuyoshi Miyakawa, Kazutaka Ikeda
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by impairments in social interaction and restricted/repetitive behaviors. The neurotransmitter γ-aminobutyric acid (GABA) through GABAA receptor signaling in the i
Externí odkaz:
https://doaj.org/article/fb45d5df75794c268efd4f6bfc23725b
Autor:
Hiroko Kotajima-Murakami, Toshiyuki Kobayashi, Hirofumi Kashii, Atsushi Sato, Yoko Hagino, Miho Tanaka, Yasumasa Nishito, Yukio Takamatsu, Shigeo Uchino, Kazutaka Ikeda
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), su
Externí odkaz:
https://doaj.org/article/b779774794c04675b2ec24c51283d035
Autor:
Miho Tanaka, Atsushi Sato, Shinya Kasai, Yoko Hagino, Hiroko Kotajima-Murakami, Hirofumi Kashii, Yukio Takamatsu, Yasumasa Nishito, Masumi Inagaki, Masashi Mizuguchi, F. Scott Hall, George R. Uhl, Dennis Murphy, Ichiro Sora, Kazutaka Ikeda
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods We
Externí odkaz:
https://doaj.org/article/25c07c7ab67344558030fde5cba9da02
Autor:
Soichiro Ide, Yuiko Ikekubo, Jennifer Hua, Yukio Takamatsu, George R. Uhl, Ichiro Sora, Kazutaka Ikeda
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 3, Pp 149-153 (2018)
Abstract Aim Attention‐deficit/hyperactivity disorder is a heterogeneous neurobiological disorder that is characterized by inattention, impulsivity, and an increase in motor activity. Although methylphenidate has been used as a medication for decad
Externí odkaz:
https://doaj.org/article/549a64fffcf04384a637ec1ef3bb5358
Autor:
Masayo Fujita, Yoko Hagino, Taishi Takeda, Shinya Kasai, Miho Tanaka, Yukio Takamatsu, Kazuto Kobayashi, Kazutaka Ikeda
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Dopamine is important for motor control and involved in the regulation of circadian rhythm. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxypheny
Externí odkaz:
https://doaj.org/article/9cf1355b0d1c4386b7edbb235b1b2ecf
Autor:
Masayo Fujita, Yoko Hagino, Yukio Takamatsu, Yuka Shimizu, Yoshiki Takamatsu, Kazutaka Ikeda, Makoto Hashimoto
Publikováno v:
Neuropsychopharmacology Reports, Vol 38, Iss 2, Pp 95-97 (2018)
Abstract Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor
Externí odkaz:
https://doaj.org/article/9364aa784d8e4ed2a75400fc1c926ac1
Autor:
Hiroko, Kotajima-Murakami, Hideo, Hagihara, Atsushi, Sato, Yoko, Hagino, Miho, Tanaka, Yoshihisa, Katoh, Yasumasa, Nishito, Yukio, Takamatsu, Shigeo, Uchino, Tsuyoshi, Miyakawa, Kazutaka, Ikeda
Publikováno v:
Frontiers in psychiatry. 13
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by impairments in social interaction and restricted/repetitive behaviors. The neurotransmitter γ
Autor:
Ichiro Sora, Yukio Takamatsu, Soichiro Ide, Yuiko Ikekubo, Jennifer Hua, Kazutaka Ikeda, George R. Uhl
Publikováno v:
Neuropsychopharmacology Reports
Aim Attention‐deficit/hyperactivity disorder is a heterogeneous neurobiological disorder that is characterized by inattention, impulsivity, and an increase in motor activity. Although methylphenidate has been used as a medication for decades, unkno
Autor:
Wenhua Han, Yukio Takamatsu, Hideko Yamamoto, Shinya Kasai, Shogo Endo, Tomoaki Shirao, Nobuhiko Kojima, Kazutaka Ikeda
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21637 (2011)
BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription. The present study sou
Externí odkaz:
https://doaj.org/article/c74c8bef65c2440099f4049d19c4d384
Autor:
Yoko Hagino, Kazutaka Ikeda, Etsuko Kamegaya, Maaya Matsuzawa, Soichiro Ide, Hideko Yamamoto, Toshifumi Yamamoto, Masayoshi Mishina, Wakako Sawada, Yukio Takamatsu
Publikováno v:
Neuropharmacology. 112:188-197
The N -methyl- d -aspartate (NMDA) receptor channel is involved in various physiological functions, including learning and memory. The GluN2D subunit of the NMDA receptor has low expression in the mature brain, and its role is not fully understood. I