Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Yukio, Kawahara"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Global alignment of complex cell state trajectories between single-cell datasets remains challenging. Here, the authors present a computational method called CAPITAL to compare branching trajectories, and demonstrate that this method achieves accurat
Externí odkaz:
https://doaj.org/article/eb237604431644b4ae1ed8f33946c197
Autor:
Masanori Yoshinaga, Kyuho Han, David W. Morgens, Takuro Horii, Ryosuke Kobayashi, Tatsuaki Tsuruyama, Fabian Hia, Shota Yasukura, Asako Kajiya, Ting Cai, Pedro H. C. Cruz, Alexis Vandenbon, Yutaka Suzuki, Yukio Kawahara, Izuho Hatada, Michael C. Bassik, Osamu Takeuchi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
In this work, Yoshinaga et al. use functional CRISPR screens and in vivo analyses to show that an RNA methyltransferase METTL16 and MTR4-nuclear exosome play an essential role in maintaining erythropoiesis and regulating DNA repair in erythroblasts.
Externí odkaz:
https://doaj.org/article/f78942b01fb44792b4c4ca4cc22d55e8
Autor:
Kotaro Miyake, Pedro Henrique Costa Cruz, Izumi Nagatomo, Yuki Kato, Daisuke Motooka, Shingo Satoh, Yuichi Adachi, Yoshito Takeda, Yukio Kawahara, Atsushi Kumanogoh
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112688- (2023)
Summary: The methyltransferase-like 3 (METTL3)-/METTL14-containing complex predominantly catalyzes N6-methyladenosine (m6A) modification, which affects mRNA stability. Although the METTL14 R298P mutation is found in multiple cancer types, its biologi
Externí odkaz:
https://doaj.org/article/4d06b0fa291e49f89d41e253e4ef13c1
Autor:
Kyoka Higuchi, Akiko Uyeda, Lili Quan, Shogo Tanabe, Yuki Kato, Yukio Kawahara, Rieko Muramatsu
Publikováno v:
Journal of Neuroscience; 10/23/2024, Vol. 44 Issue 43, p1-11, 11p
Autor:
Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
Publikováno v:
PLoS Genetics, Vol 17, Iss 5, p e1009516 (2021)
Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150. Deletion of Adar1 or Adar1 p150 genes in mice results in embryonic lethality with
Externí odkaz:
https://doaj.org/article/4fd9f310797d4b7fb120f61b36629513
Autor:
Yoshitaka Kanemitsu, Masashi Fujitani, Yuki Fujita, Suxiang Zhang, You-Qiang Su, Yukio Kawahara, Toshihide Yamashita
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Cortical neurogenesis is a fundamental process of brain development that is spatiotemporally regulated by both intrinsic and extrinsic cues. Although recent evidence has highlighted the significance of transcription factors in cortical neuro
Externí odkaz:
https://doaj.org/article/72811c53c1224cf6a19e1357979e9cc7
Autor:
Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
Adenosine-to-inosine RNA editing is catalyzed by nuclear ADAR1 p110 and ADAR2, and cytoplasmic ADAR1 p150 in mammals, all of which recognize double-stranded RNAs (dsRNAs) as targets. Although its frequency is quite rare, RNA editing occurs in coding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e423a7ae0969a184b1680b31e19323
https://doi.org/10.1101/2023.04.17.537126
https://doi.org/10.1101/2023.04.17.537126
Autor:
Hiroyuki Todo, Yuki Kato, Jung In Kim, Maal Inoue, Eiichi Morii, Ryuichiro Yamasaki, Yukio Kawahara, Taisuke Nakahama, Yanfang Xing, Toshiharu Shibuya
Publikováno v:
The Journal of Immunology. 207:3016-3027
Aicardi–Goutières syndrome (AGS) is a congenital inflammatory disorder accompanied by overactivated type I IFN signaling and encephalopathy with leukodystrophy and intracranial calcification. To date, none of the mouse models carrying an AGS-causa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88bf8d528d5ea77f823976d39045f970
https://doi.org/10.4049/jimmunol.2100526
https://doi.org/10.4049/jimmunol.2100526
Autor:
Taisuke Nakahama, Yukio Kawahara
Publikováno v:
International immunology.
Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-editing enzyme that catalyzes adenosine-to-inosine conversions in double-stranded RNAs (dsRNAs). In mammals, ADAR1 is composed of two isoforms: a nuclear short p110 isoform and a cytoplasmic long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a6ff1061a193979e5cc1d3bb8088b3
https://pubmed.ncbi.nlm.nih.gov/36469491
https://pubmed.ncbi.nlm.nih.gov/36469491
Autor:
Tatsunori Suzuki, Rieko Muramatsu, Yuki Kato, Lili Quan, Yukio Kawahara, Noritaka Ichinohe, Shogo Tanabe, Akiko Uyeda, Kazuhisa Sakai, Nagaaki Muramatsu
Publikováno v:
Glia. 69:2591-2604
Remyelination is a regenerative process that restores the lost neurological function and partially depends on oligodendrocyte differentiation. Differentiation of oligodendrocytes spontaneously occurs after demyelination, depending on the cell intrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6d46a61a35f3a1b70f634bf578ef50
https://doi.org/10.1002/glia.24060
https://doi.org/10.1002/glia.24060