Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yukinori Isomura"'
Autor:
Tetsuya Suwa, Yukinori Isomura, Tomoatsu Mune, Yoritsuna Yamamoto, Nobuki Takada, Jun Takeda, Kohei Kaku, Perrin C. White, Hiroyuki Morita
Publikováno v:
Hypertension Research. 36:614-619
Type 2 11β-hydroxysteroid dehydrogenase encoded by the HSD11B2 gene converts cortisol to inactive cortisone and thus protects the mineralocorticoid receptor from cortisol exposure. Impaired activity of this enzyme leads to mineralocorticoid excess,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348b292484e75b6e342d734033feb753
https://doi.org/10.1038/hr.2013.13
https://doi.org/10.1038/hr.2013.13
Autor:
Makoto Hayashi, Yukinori Isomura, Noriyuki Takeda, Akihiko Sasaki, Tomoatsu Mune, Jun Takeda, Perrin C. White, Nobuki Takada, Hiroyuki Morita, Yoritsuna Yamamoto, Noriyoshi Yamakita, Tetsuya Suwa, Kohei Kaku
Publikováno v:
Endocrine Journal. 60:671-678
Type 2 11β-hydroxysteroid dehydrogenase encoded by the HSD11B2 gene converts cortisol to inactive cortisone, and alteration in this enzymatic activity might affect glucose homeostasis by affecting circulating levels or tissue availability of glucoco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c105686808197febba430e80bd3402f
https://doi.org/10.1507/endocrj.ej12-0108
https://doi.org/10.1507/endocrj.ej12-0108
Autor:
Jun Takeda, Tetsuya Suwa, Nobuki Takada, Yukinori Isomura, Hiroyuki Morita, Yoritsuna Yamamoto, Tomoatsu Mune
Publikováno v:
Metabolism. 55:1352-1357
We developed enzyme-linked immunosorbent assays to measure urinary free cortisone (E) and cortisol (F) and analyzed correlations between clinical measures reflecting mineralocorticoid action and 24-hour urinary excretion of E and F or their ratio, uE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173e845ea067147bd1cb72d997c7b173
https://doi.org/10.1016/j.metabol.2006.06.005
https://doi.org/10.1016/j.metabol.2006.06.005
Autor:
Hisashi Daido, Rieko Takami, Keigo Yasuda, Tomoatsu Mune, Hiroyuki Morita, Celso E. Gomez-Sanchez, Yukinori Isomura, Noriyoshi Yamakita, Noriyuki Takeda, Tatsuo Ishizuka
Publikováno v:
Metabolism. 53:89-94
Two isozymes of the 11β-hydroxysteroid dehydrogenase (11-HSD) are responsible for the interconversion of cortisol (F) and cortisone (E). The type 1 isozyme, 11-HSD1, acts mainly as a reductase in vivo, activating E to F, whereas the type 2, 11-HSD2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11e39144ca0a926585991fc1d509486
https://doi.org/10.1016/j.metabol.2003.06.005
https://doi.org/10.1016/j.metabol.2003.06.005
Autor:
Takashi Suzuki, Hironobu Sasano, Hiroyuki Morita, Yukinori Isomura, Takashi Deguchi, Y Takahashi, Hisashi Daido, Keigo Yasuda, Perrin C. White, Noriyoshi Yamakita, Tetsuya Tanahashi, Tomoatsu Mune
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 88:864-870
It is not understood why some adrenal adenomas are nonfunctional and others with similar histopathology cause preclinical or overt Cushing's syndrome. Two isozymes of 11 beta-hydroxysteroid dehydrogenase, types 1 and 2 (HSD11B1 and HSD11B2), are know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5ca70efabafd849c2a0fddfa52f7a7
https://doi.org/10.1210/jc.2001-011335
https://doi.org/10.1210/jc.2001-011335
Autor:
Mako Isaji, Hisashi Daido, Keigo Yasuda, Tetsuya Suwa, Junko Hanafusa, Hiroyuki Morita, Masanori Murayama, Yukinori Isomura, Tomoatsu Mune, Tetsuya Tanahashi
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 282:E466-E473
To evaluate the effects of altered corticosteroid metabolism on the hypothalamic-pituitary-adrenal axis, we examined rats treated with glycyrrhizic acid (G rats) or rifampicin (R rats) for 7 days. The half-life of exogenously administered hydrocortis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33bd920f13671d56f2a3c82b1aba6ef8
https://doi.org/10.1152/ajpendo.00065.2001
https://doi.org/10.1152/ajpendo.00065.2001
Autor:
Tomoatsu, Mune, Tetsuya, Suwa, Hiroyuki, Morita, Yukinori, Isomura, Nobuki, Takada, Yoritsuna, Yamamoto, Makoto, Hayashi, Noriyoshi, Yamakita, Akihiko, Sasaki, Noriyuki, Takeda, Jun, Takeda, Perrin C, White, Kohei, Kaku
Publikováno v:
Endocrine journal. 60(5)
Type 2 11β-hydroxysteroid dehydrogenase encoded by the HSD11B2 gene converts cortisol to inactive cortisone, and alteration in this enzymatic activity might affect glucose homeostasis by affecting circulating levels or tissue availability of glucoco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ac60e30c028c004eb407f46b3f892c2
https://pubmed.ncbi.nlm.nih.gov/23357976
https://pubmed.ncbi.nlm.nih.gov/23357976
Autor:
Noriyoshi Yamakita, Takashi Suzuki, Hisashi Daido, Hiroyuki Morita, Y Takahashi, Yukinori Isomura, Takashi Deguchi, Hironobu Sasano, Tomoatsu Mune, Tetsuya Tanahashi, Perrin C. White, Keigo Yasuda
Publikováno v:
Endocrine research. 28(4)
Third Department of Internal Medicine (T.M., Y.I., T.T., H.D., K.Y.), Department of General Medicine (H.M.), and Department of Urology (Y.T., T.D.), Gifu University School of Medicine, Gifu 500-8705, Japan; Matsunami General Hospital (N.Y.), Gifu 501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ae70bf0c825ff527683a4c536323f3
https://pubmed.ncbi.nlm.nih.gov/12530692
https://pubmed.ncbi.nlm.nih.gov/12530692
Autor:
Hiroyuki Morita, Yukinori Isomura, Tetsuya Tanahashi, Keigo Yasuda, Celso E. Gomez-Sancehz, Tomoatsu Mune, Hiromichi Tanahashi, Hisashi Daido, Tetsuya Suwa
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 80(4-5)
Licorice-derivatives such as glycyrrhizic acid (GA) competitively inhibit 11 beta-hydroxysteroid dehydrogenase(11 beta-HSD) type 2 (11-HSD2) enzymatic activity, and chronic clinical use often results in pseudoaldosteronism. Since the effect of GA on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f05068a4f6be8fd2ee739ba5937a24
https://pubmed.ncbi.nlm.nih.gov/11983491
https://pubmed.ncbi.nlm.nih.gov/11983491
Autor:
Yukinori Isomura, Hiroshi Sarui, Mako Isaji, Hiroyuki Morita, Tomoatsu Mune, Hisashi Daido, Tatsuo Ishizuka, Noriyuki Takeda, Keigo Yasuda, Tetsuya Tanahashi
Publikováno v:
The American journal of the medical sciences. 323(3)
A 49-year-old man, diagnosed as having Cushing disease in 1976 at the age of 26, underwent a Hardy operation 13 years after treatment with reserpine combined with pituitary radiation. In laboratory examinations before and 2 weeks after the successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e9431b5a218f69bd497b5eeecfe105
https://pubmed.ncbi.nlm.nih.gov/11908863
https://pubmed.ncbi.nlm.nih.gov/11908863