Zobrazeno 1 - 10 of 43 pro vyhledávání: '"Yukinori Endo"'
1
Akademický článek
Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model
Autor: Yukinori Endo, Brady T. Hickerson, Natalia A. Ilyushina, Nishant Mohan, Hanjing Peng, Kazuyo Takeda, Raymond P. Donnelly, Wen Jin Wu
Publikováno v: Journal of Virus Eradication, Vol 8, Iss 4, Pp 100307- (2022)
Because of rapid emergence and circulation of the SARS-CoV-2 variants, especially Omicron which shows increased transmissibility and resistant to antibodies, there is an urgent need to develop novel therapeutic drugs to treat COVID-19. In this study
Externí odkaz: https://doaj.org/article/1d7b6943a99e4c21b90be6a868556f19
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2
Akademický článek
Atezolizumab Induces Necroptosis and Contributes to Hepatotoxicity of Human Hepatocytes
Autor: Yukinori Endo, Katie L. Winarski, Md Sanaullah Sajib, Anna Ju, Wen Jin Wu
Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 14, p 11694 (2023)
Atezolizumab is an immune checkpoint inhibitor (ICI) targeting PD-L1 for treatment of solid malignancies. Immune checkpoints control the immune tolerance, and the adverse events such as hepatotoxicity induced by ICIs are often considered as an immune
Externí odkaz: https://doaj.org/article/2e8ac4463ec649e5b903e306f2cd4f7e
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3
Akademický článek
Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1
Autor: Nishant Mohan, Atul Agrawal, Yi Shen, Katie L. Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S. Rotstein, Lorraine C. Pelosof, Wen Jin Wu
Publikováno v: Pharmaceutics, Vol 14, Iss 7, p 1381 (2022)
We generated two IgG1-like bispecific antibodies (BsAbs) with different molecular formats, symmetrical DVD-Ig and asymmetrical knob-in-hole (KIH), targeting the same antigens, EGFR and PD-L1 (designated as anti-EGFR/PD-L1). We performed the physioche
Externí odkaz: https://doaj.org/article/58be08b2889c41238320db318c0f3eb4
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4
Akademický článek
Atezolizumab potentiates Tcell-mediated cytotoxicity and coordinates with FAK to suppress cell invasion and motility in PD-L1+ triple negative breast cancer cells
Autor: Nishant Mohan, Salman Hosain, Jun Zhao, Yi Shen, Xiao Luo, Jiangsong Jiang, Yukinori Endo, Wen Jin Wu
Publikováno v: OncoImmunology, Vol 8, Iss 9 (2019)
Immune check point inhibitors targeting programmed cell death protein-1 (PD-1) and its ligand (PD-L1) have shown clinical success in treatment of human malignancies. Triple negative breast cancer (TNBC), which is primarily characterized by high heter
Externí odkaz: https://doaj.org/article/7656b417095747d3a173b67310cf7cc0
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5
Akademický článek
Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1β and TRIF/IRF3.
Autor: Yukinori Endo, Ksenia Blinova, Tatiana Romantseva, Hana Golding, Marina Zaitseva
Publikováno v: PLoS ONE, Vol 9, Iss 5, p e98517 (2014)
Prostaglandin E2 (PGE2) is induced in vivo by bacterial products including TLR agonists. To determine whether PGE2 is induced directly or via IL-1β, human monocytes and macrophages were cultured with LPS or with Pam3CSK4 in presence of caspase-1 inh
Externí odkaz: https://doaj.org/article/1f6fe539e34e484eb31c719699f39185
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8
Abstract 5310: Physiochemical and biological characterization of anti-EGFR based bispecific antibodies in triple negative breast cancer (TNBC) models
Autor: Nishant Mohan, Xiao Luo, Yi Shen, Zachary Olson, Atul Agrawal, Yukinori Endo, David Rotstein, Lorraine Pelosof, Wen Jin Wu
Publikováno v: Cancer Research. 82:5310-5310
Triple-negative breast cancer (TNBC) accounts for approximately 10-20% of all diagnosed breast cancer. Both epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) frequently overexpress in TNBC and cooperat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfa00ed1dd59a4ae37f4ae20cacfcd52
https://doi.org/10.1158/1538-7445.am2022-5310
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9
Payload of T-DM1 binds to cell surface cytoskeleton-associated protein 5 to mediate cytotoxicity of hepatocytes
Autor: Yukinori Endo, Yi Shen, Kazuyo Takeda, David S. Rotstein, Jiangsong Jiang, Wen Jin Wu, Nishant Mohan
Publikováno v: Oncotarget
Off-target toxicity is a major cause of dose-limiting toxicity for antibody-drug conjugates (ADCs), mechanisms of which remain poorly understood. Here, we demonstrate that cytoskeleton-associated protein 5 (CKAP5) serves as a cell surface target for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0218c58cd933e9d99fce3d344cd8f19
https://doi.org/10.18632/oncotarget.26461
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10
Tumor Extrinsic Factors Mediate Primary T-DM1 Resistance in HER2-Positive Breast Cancer Cells
Autor: Wen Jin Wu, Yukinori Endo
Publikováno v: Cancers, Vol 13, Iss 2331, p 2331 (2021)
Cancers
Volume 13
Issue 10
Simple Summary In this investigation, we employed an unconventional approach to explore the mechanisms of the primary resistance of human epidermal growth factor 2 (HER2)-positive breast cancer cells to ado-trastuzumab emtansine (also known as T-DM1)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1f6574c208439bfe50618aa44ee344
https://www.mdpi.com/2072-6694/13/10/2331
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