Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Yukinori Arai"'
Autor:
Midori Yamashita, Mamoru Tasaki, Ryuji Murakami, Yukinori Arai, Takafumi Nakamura, Shinsuke Nakao
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 422-432 (2021)
Characterization of the intratumoral immune status is important for developing immunotherapies and evaluating their antitumor effectiveness. CD8+ T cells are one of the most important cell types that directly and indirectly contribute to antitumor ef
Externí odkaz:
https://doaj.org/article/68c97007a1944f55bdad940f1f063c9f
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 1, Pp 53-59 (2009)
Hyponatremia is the most common electrolyte disorder in hospitalized patients and is associated with the risk of intractable seizures and death. The effectiveness of conventional therapies for hyponatremia is inconsistent, and the rapid correction of
Externí odkaz:
https://doaj.org/article/c9adc9cb9ea64343bce104c7305ef80e
Publikováno v:
Cancer Immunology, Immunotherapy
Immune checkpoint inhibitors against PD-1, PD-L1 and CTLA-4 have altered the treatment paradigm for various types of cancers in the past decade. However, they offer clinical benefits to only a subset of patients. Evaluation and identification of an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861890a9ecf974ac5d5d7001626076a6
https://doi.org/10.1007/s00262-021-02947-y
https://doi.org/10.1007/s00262-021-02947-y
Autor:
Nobuaki Amino, Mamoru Tasaki, Yukinori Arai, Shinsuke Nakao, Ryuji Murakami, Midori Yamashita, Takafumi Nakamura, Motomu Nakatake, Hajime Kurosaki, Masamichi Mori, Tatsuya Kawase, Masahiro Takeuchi
Publikováno v:
Science Translational Medicine. 12
The immune status of the tumor microenvironment is a key indicator in determining the antitumor effectiveness of immunotherapies. Data support the role of activation and expansion of tumor-infiltrating lymphocytes (TILs) in increasing the benefit of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08464b95da8e37dcfff7fb66fe21767e
https://doi.org/10.1126/scitranslmed.aax7992
https://doi.org/10.1126/scitranslmed.aax7992
Autor:
Nobuaki Amino, Mamoru Tasaki, Takafumi Nakamura, Masahiro Takeuchi, Yukinori Arai, Tatsuya Kawase, Shinsuke Nakao, Motomu Nakatake, Hajime Kurosaki, Ryuji Murakami, Midori Yamashita, Masamichi Mori
Publikováno v:
Molecular Cancer Therapeutics. 18:B019-B019
While immune checkpoint inhibitors have markedly improved therapeutic outcomes for cancer patients, only a subset of patients exhibit a long-term durable response. A number of approaches have been trialed in preclinical and clinical studies to overco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7ea40cd4016d6dc01f00325e4091080
https://doi.org/10.1158/1535-7163.targ-19-b019
https://doi.org/10.1158/1535-7163.targ-19-b019
Autor:
Koh-ichi Wada, Akira Fujimori, Katsumi Sudoh, Yukinori Arai, Keiji Miyata, Utane Matsukawa, Masao Sasamata
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:91-95
We investigated the effects of intravenous administration of conivaptan hydrochloride, a dual vasopressin V1A and V2 receptor antagonist, on blood electrolytes and plasma osmolality in rats with an experimental syndrome of inappropriate secretion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a05f381c8c5ed2b4fbf2be24231c37
https://doi.org/10.1248/bpb.30.91
https://doi.org/10.1248/bpb.30.91
Autor:
Jason J. Luke, Geoffrey I. Shapiro, Allam Fakhoury, Takao Yamazaki, Carl Dmuchowski, Jeffrey R. Infante, Patricia LoRusso, Yukinori Arai, Andrew Krivoshik, Robin Schuster
Publikováno v:
Cancer chemotherapy and pharmacology. 77(3)
ASP9853 is an inhibitor of inducible nitric oxide (NO) synthase (iNOS) dimerization, which results in decreased NO production. Here, we report preclinical pharmacology of ASP9853 and the impact of ASP9853 in combination with a taxane on tumor volume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e260e8d5bdfb39a42885776488378f
https://pubmed.ncbi.nlm.nih.gov/26811179
https://pubmed.ncbi.nlm.nih.gov/26811179
Autor:
Junko Tsukada, Motonori Aoki, Atsuo Tahara, Koh-ichi Wada, Yuichi Tomura, Takeyuki Yatsu, Yukinori Arai
Publikováno v:
European Journal of Pharmacology. 450:169-177
Myocardial infarction often induces congestive heart failure accompanied by a significant increase in plasma vasopressin concentration. To delineate the role of vasopressin in the pathogenesis of congestive heart failure, the acute hemodynamic and aq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677ae6940b65b564f29edb5d24129ed2
https://doi.org/10.1016/s0014-2999(02)02101-5
https://doi.org/10.1016/s0014-2999(02)02101-5
Autor:
Yousuke Katsuda, Mitsutaka Yamamoto, Yukinori Arai, Makoto Usui, Kensuke Egashira, Hideo Tada, Akira Takeshita, Hiroaki Shimokawa
Publikováno v:
Japanese Circulation Journal. 65:827-833
The role of endothelium-derived nitric oxide (NO) in the metabolic control of coronary blood flow (CBF) in heart failure (HF) is poorly understood, so the present study investigated the effects of inhibitors of NO synthesis on the response of CBF to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fad45c5ea6a0d577cc529d3f0c1f9a6
https://doi.org/10.1253/jcj.65.827
https://doi.org/10.1253/jcj.65.827
Autor:
Yukinori Arai, Keiko Suzuki, Hirotoshi Kakuta, Hideyuki Tanaka, Toshiyuki Funatsu, Keiji Miyata
Publikováno v:
Folia Pharmacologica Japonica. 117:65-76
Hypercholesterolemia is a major risk factor for the development of coronary heart disease. HMG-CoA reductase inhibitors have been used as first-line drugs because of both their superior cholesterol lowering effect and reliable safety profile. Since t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::729885eddd37078f083243f702f761db
https://doi.org/10.1254/fpj.117.65
https://doi.org/10.1254/fpj.117.65