Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Yukina Nishito"'
Autor:
Takumi Wagatsuma, Eisuke Suzuki, Miku Shiotsu, Akiko Sogo, Yukina Nishito, Hideya Ando, Hisashi Hashimoto, Michael J. Petris, Masato Kinoshita, Taiho Kambe
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3 copper proteins, with binuclear copper active sites. Although there is experimental evidence f
Externí odkaz:
https://doaj.org/article/ba217f3439014ff892ecfb33883a13ee
Autor:
Shino Nagamatsu, Yukina Nishito, Hana Yuasa, Nao Yamamoto, Taiki Komori, Takuya Suzuki, Hiroyuki Yasui, Taiho Kambe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The zinc homeostatic proteins Zn transporter 1 (ZNT1) and metallothionein (MT) function in dampening increases in cytosolic zinc concentrations. Conversely, the expression of ZNT1 and MT is expected to be suppressed during decreases in cytos
Externí odkaz:
https://doaj.org/article/47e331b36f44468c9e49e4600508c755
Autor:
Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Selenoprotein P is secreted by the liver and when present in excess it promotes development of type 2 diabetes. Here the authors develop neutralizing antibodies to target human and mouse selenoprotein P, and show that they improve insulin secretion a
Externí odkaz:
https://doaj.org/article/9072caa59698443ba30fe40fdc34e5b3
Autor:
Yukina Nishito, Kathryn Mary Taylor, Naoya Kubo, Tokuji Tsuji, Yu-ki Tanaka, Sachiko Ueda, Eisuke Suzuki, Yasumitsu Ogra, Mayu Matsunaga, Tomohiro Yamazaki, Taka-aki Takeda, Ayako Fukunaka, Taiho Kambe, Namino Ogawa, Takashi Fujiwara
Publikováno v:
J Biol Chem
Numerous zinc ectoenzymes are metalated by zinc and activated in the compartments of the early secretory pathway before reaching their destination. Zn transporter (ZNT) proteins located in these compartments are essential for ectoenzyme activation. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fb8beda46493f1a12bfe36d136aff9
https://doi.org/10.1074/jbc.ra120.012610
https://doi.org/10.1074/jbc.ra120.012610
Autor:
Yukina Nishito, Taiho Kambe
Publikováno v:
J Biol Chem
Zinc transporter 1 (ZNT1) is the only zinc transporter predominantly located on the plasma membrane, where it plays a pivotal role exporting cytosolic zinc to the extracellular space. Numerous studies have focused on the physiological and pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8ebf5fb693650814d1b5772ef1cb03
http://hdl.handle.net/2433/244791
http://hdl.handle.net/2433/244791
Autor:
Kenji, Arimitsu, Yusuke, Yagi, Kazuhiro, Koshino, Yukina, Nishito, Takahiro, Higuchi, Hiroyuki, Yasui, Hiroyuki, Kimura
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
Glucose transporter 2 (GLUT2) is involved in glucose uptake by hepatocytes, pancreatic beta cells, and absorptive cells in the intestine and proximal tubules in the kidney. Pancreatic GLUT2 also plays an important role in the mechanism of glucose-sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e0db639c3203f439f91a7496396f69f
https://pubmed.ncbi.nlm.nih.gov/32738964
https://pubmed.ncbi.nlm.nih.gov/32738964
Publikováno v:
Studies of Epithelial Transporters and Ion Channels ISBN: 9783030554538
Zinc is an essential trace element in humans. As zinc plays pivotal roles as a structural, catalytic, and signaling component of many proteins, its deficiency causes diverse pathophysiological symptoms. Although an adult human body contains only 2–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4616b1060901598ff3ae231f7b0f91bd
https://doi.org/10.1007/978-3-030-55454-5_11
https://doi.org/10.1007/978-3-030-55454-5_11
Autor:
Yukina Nishito, Takahiro Nagamura, Toshinari Takamura, Yuki Kuzuhara, Naoko Sakai, Miki Iwasaki, Yuya Yoshioka, Hirofumi Misu, Noriko Noguchi, Kanade Sotani, Shogo Inari, Yoshiro Saito, Kumi Inagaki, Kaho Nakayama, Yuichiro Mita, Masaya Ikegawa
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications
Selenoprotein P (SeP) functions as a selenium (Se)-supply protein. SeP is identified as a hepatokine, promoting insulin resistance in type 2 diabetes. Thus, the suppression of Se-supply activity of SeP might improve glucose metabolism. Here, we devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226b6b78d59c99b89d889456c152426a
http://link.springer.com/article/10.1038/s41467-017-01863-z
http://link.springer.com/article/10.1038/s41467-017-01863-z
Autor:
Israel Sekler, Yusaku Miyamae, Masaya Nagao, Eitan Hoch, Kazuhisa Fukue, Tokuji Tsuji, Dax Fu, Ayako Fukunaka, Taiho Kambe, Seiji Masuda, Taka-aki Takeda, Takashi Fujiwara, Chengfeng Merriman, Yukina Nishito, Shigeyuki Fujimoto
Publikováno v:
Biochemical Journal. 473:2611-2621
Secretory and membrane-bound zinc-requiring enzymes are thought to be activated by binding zinc in the early secretory pathway. One such enzyme, tissue-non-specific alkaline phosphatase (TNAP), is activated through a two-step mechanism, via protein s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d7f2de1041fb43fbda1ec78032375a
https://doi.org/10.1042/bcj20160324
https://doi.org/10.1042/bcj20160324