Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy

Autor: Yukiko Yamamoto-Watanabe, Kiyofumi Yamada, Atsushi Sasaki, Takeshi Kawarabayashi, Yasuhito Wakasaya, Mikio Shoji, Peter St. George Hyslop, Ayumi Takamura, Koji Abe, Tetsuro Murakami, Tomoko Kurata, Etsuro Matsubara, Koichi Wakabayashi, David Westaway, Mitsunori Watanabe

Publikováno v: Journal of Neuroscience Research. 89:576-584

TgTauP301L mice that overexpress the mutant human tauP301L present in FTDP-17 reproduce neurofibrillary tangles (NFTs), neuronal cell losses, memory disturbance, and substantial phenotypic variation. To demonstrate factors responsible for NFT formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997633707249afbc76451d2313983959
https://doi.org/10.1002/jnr.22572

Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model

Autor: Koji Abe, Tetsuro Murakami, Tomoko Kurata, Masaki Ikeda, Yusuke Seino, Mitsunori Watanabe, Ayumi Takamura, Takeshi Kawarabayashi, Yasuhito Wakasaya, David Westaway, Peter St. George Hyslop, Etsuro Matsubara, Mikio Shoji, Yukiko Yamamoto-Watanabe

Publikováno v: Journal of Neuroscience Research. 88:3547-3554

In Alzheimer's disease, Aβ deposits are considered the initial cardinal events that induce tauopathy secondarily. However, the relationship between Aβ amyloidosis and tauopathy has not been determined in detail. We produced double transgenic mice,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a616d53017390319695d9eac20e067e4
https://doi.org/10.1002/jnr.22516

Prevalence of Autosomal Dominant Cerebellar Ataxia in Aomori, the Northernmost Prefecture of Honshu, Japan

Autor: Yoshio Ikeda, Mikio Shoji, Yasuhito Wakasaya, Mandy Jackson, Motofumi Hikichi, Mitsunori Watanabe, Yukiko Yamamoto-Watanabe, Takeshi Kawarabayashi, Etsuro Matsubara, Kazuya Kannari

Publikováno v: Internal Medicine. 49:2409-2414

Objective The frequency of autosomal dominant cerebellar ataxia (ADCA) varies between different regions of Japan. This is the first report on the prevalence of ADCA subtypes in Aomori, Japan. Methods and Patients Sixty-five familial spinocerebellar a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2513d46e62ab8d2a25320a7c11ac774d
https://doi.org/10.2169/internalmedicine.49.4025

An Unusual Case of Elderly-Onset Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) With Multiple Cerebrovascular Risk Factors

Autor: Mitsunori Watanabe, Ayumi Takamura, Mikio Shoji, Mandy Jackson, Yasuhito Wakasaya, Yoshiki Adachi, Takeshi Kawarabayashi, Etsuro Matsubara, Yukiko Yamamoto-Watanabe, Ikumi Shirahama

Publikováno v: Journal of Stroke and Cerebrovascular Diseases. 21:143-145

Here we report a female patient with elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). At age 71, she developed gait disturbance, followed by memory disturbance 1 year later. She had b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40986d5d3755bfe6c13ab525d54129df
https://doi.org/10.1016/j.jstrokecerebrovasdis.2010.05.008

A small trinucleotide expansion in the TBP gene gives rise to a sporadic case of SCA17 with abnormal putaminal findings on MRI

Autor: Yukiko Yamamoto-Watanabe, Mikio Shoji, Yasuhito Wakasaya, Yoshio Ikeda, Mandy Jackson, Chieko Suzuki, Yusuke Seino, Etsuro Matsubara, Mitsunori Watanabe, Takeshi Kawarabayashi, Natsuki Monai, Masahiko Tomiyama, Yasuo Miki, Tamaki Kimura

Publikováno v: Watanabe, M, Monai, N, Jackson, M, Yamamoto-Watanabe, Y, Ikeda, Y, Suzuki, C, Tomiyama, M, Kawarabayashi, T, Kimura, T, Seino, Y, Wakasaya, Y, Miki, Y, Matsubara, E & Shoji, M 2008, ' A Small Trinucleotide Expansion in the TBP Gene Gives Rise to a Sporadic Case of SCA17 with Abnormal Putaminal Findings on MRI ', Internal Medicine, vol. 47, no. 24, pp. 2179-2182 . https://doi.org/10.2169/internalmedicine.47.1499

A Japanese woman developed gait disturbances at 25 years of age, and subsequently underwent gradual changes in her personality. By the age of 42, she showed clear signs of dementia and cerebellar ataxia, and displayed behavioral abnormalities, chorei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a593347efa64cad51351e0fae99d4a9
https://pubmed.ncbi.nlm.nih.gov/19075547