Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yukiko Togashi"'
Autor:
Wenwen Wu, Jing Zhu, Naoe Taira Nihira, Yukiko Togashi, Atsushi Goda, Junki Koike, Kiyoshi Yamaguchi, Yoichi Furukawa, Takuya Tomita, Yasushi Saeki, Yoshikazu Johmura, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Epigenetic dysregulation affecting oncogenic transcription and DNA damage response is a hallmark of cancer. The histone demethylase KDM4B, a factor regulating these processes, plays important roles in estrogen receptor-mediated tr
Externí odkaz:
https://doaj.org/article/495f1b5e342f41eeacc7052e5521f4b0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The nucleolus is a nuclear structure composed of ribosomal DNA (rDNA), and functions as a site for rRNA synthesis and processing. The rDNA is guanine-rich and prone to form G-quadruplex (G4), a secondary structure of DNA. We have recently fo
Externí odkaz:
https://doaj.org/article/8dc79e6081f24ef6a68a4ba40ee58c67
Autor:
Tomohiko Ohta, Keiji Tanaka, Yasushi Saeki, Nao Suzuki, Yasuo Miyoshi, Naoko Arai, Hiroyuki Nishikawa, Yukiko Togashi, Reo Maruyama, Yongqiang Lai, Jun Takeuchi, Nana Rokutanda, Wenwen Wu
Affinity purification of HERC2 complex and Mass Spectrometry; Sister chromatid exchange (SCE) assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b1ea69a2808edd2c001a244535b56b
https://doi.org/10.1158/0008-5472.22419297
https://doi.org/10.1158/0008-5472.22419297
Autor:
Tomohiko Ohta, Keiji Tanaka, Yasushi Saeki, Nao Suzuki, Yasuo Miyoshi, Naoko Arai, Hiroyuki Nishikawa, Yukiko Togashi, Reo Maruyama, Yongqiang Lai, Jun Takeuchi, Nana Rokutanda, Wenwen Wu
BLM and WRN are RecQ DNA helicasesessential for genomic stability. Here, we demonstrate that HERC2, a HECT E3 ligase, is critical for their functions to suppress G-quadruplex (G4) DNA. HERC2 interacted with BLM, WRN, and replication protein A (RPA) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e9eac19cc2c030815aa3c718868c1f6
https://doi.org/10.1158/0008-5472.c.6510345.v1
https://doi.org/10.1158/0008-5472.c.6510345.v1
Autor:
Tomohiko Ohta, Keiji Tanaka, Yasushi Saeki, Nao Suzuki, Yasuo Miyoshi, Naoko Arai, Hiroyuki Nishikawa, Yukiko Togashi, Reo Maruyama, Yongqiang Lai, Jun Takeuchi, Nana Rokutanda, Wenwen Wu
S1. Analyses of HERC2 complex immunoprecipitated with a newly generated antibody; S2. HERC2 regulates BLM-RPA complex formation; S3. Effect of HERC2 depletion on BLM-RPA and WRN-RPA complex formation was reproduced with a different shRNA; S4. Detecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a010b84259e21051bead3bef6df18aa6
https://doi.org/10.1158/0008-5472.22419300.v1
https://doi.org/10.1158/0008-5472.22419300.v1
Autor:
Jing Zhu, Wenwen Wu, Yukiko Togashi, Naoe Taira Nihira, Yoshikazu Johmura, Dajiang Zhu, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta
Publikováno v:
Breast cancer (Tokyo, Japan). 29(6)
Background Sacituzumab govitecan is an antibody–drug conjugate that delivers SN-38, an active metabolite of irinotecan, to the target molecule, trophoblast cell-surface antigen 2 (Trop-2). It is a promising drug for triple-negative breast cancer an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0beb32ad7bcee738e888fc32aaaa4822
https://pubmed.ncbi.nlm.nih.gov/35882754
https://pubmed.ncbi.nlm.nih.gov/35882754
Autor:
Nana Rokutanda, Tomohiko Ohta, Yongqiang Lai, Yukiko Togashi, Mingzhang Zhu, Wenwen Wu, Weixin Liang
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Replication protein A (RPA) binds to and stabilizes single-stranded DNA and is essential for the genome stability. We reported that an E3 ubiquitin ligase, HERC2, suppresses G-quadruplex (G4) DNA by regulating RPA-helicase complexes. However, the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4330db07309c40e28a23c60313be2fe
http://link.springer.com/article/10.1038/s41598-019-50812-x
http://link.springer.com/article/10.1038/s41598-019-50812-x
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
The nucleolus is a nuclear structure composed of ribosomal DNA (rDNA), and functions as a site for rRNA synthesis and processing. The rDNA is guanine-rich and prone to form G-quadruplex (G4), a secondary structure of DNA. We have recently found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ac2d5f34d28a7f922d0045070e7ab5
http://europepmc.org/articles/PMC7801386
http://europepmc.org/articles/PMC7801386
Autor:
Yoshikazu Johmura, Makoto Nakanishi, Yasuo Miyoshi, Yukiko Togashi, Sachihiko Nobuoka, Wenwen Wu, Tomohiko Ohta
Publikováno v:
Cancer Science
The breast and ovarian cancer predisposition protein BRCA1 forms three mutually exclusive complexes with Fanconi anemia group J protein (FANCJ, also called BACH1 or BRIP1), CtIP, and Abraxas/RAP80 through its BRCA1 C terminus (BRCT) domains, while it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b8cb1871f2598a48b1f72babf39ba3
http://europepmc.org/articles/PMC5084677
http://europepmc.org/articles/PMC5084677
Autor:
Hiroyuki Nishikawa, Nana Rokutanda, Yasuo Miyoshi, Tomohiko Ohta, Naoko Arai, Yongqiang Lai, Jun Takeuchi, Yasushi Saeki, Nao Suzuki, Reo Maruyama, Wenwen Wu, Keiji Tanaka, Yukiko Togashi
Publikováno v:
Cancer research. 78(22)
BLM and WRN are RecQ DNA helicasesessential for genomic stability. Here, we demonstrate that HERC2, a HECT E3 ligase, is critical for their functions to suppress G-quadruplex (G4) DNA. HERC2 interacted with BLM, WRN, and replication protein A (RPA) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33ba45e779d28eda81ee5738861bbed
https://pubmed.ncbi.nlm.nih.gov/30279242
https://pubmed.ncbi.nlm.nih.gov/30279242