Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yukiko Nasu-Nishimura"'
Autor:
Tsutomu Nakamura, Fumika Sakaue, Yukiko Nasu-Nishimura, Yasuko Takeda, Ken Matsuura, Tetsu Akiyama
Publikováno v:
EBioMedicine, Vol 34, Iss , Pp 189-200 (2018)
GABAergic dysfunction underlies many neurodevelopmental and psychiatric disorders. GABAergic synapses exhibit several forms of plasticity at both pre- and postsynaptic levels. NMDA receptor (NMDAR)–dependent inhibitory long-term potentiation (iLTP)
Externí odkaz:
https://doaj.org/article/e755f80472964f689b4a4c7f8177f4c2
Autor:
Tsutomu Nakamura, Fumiko Arima-Yoshida, Fumika Sakaue, Yukiko Nasu-Nishimura, Yasuko Takeda, Ken Matsuura, Natacha Akshoomoff, Sarah N. Mattson, Paul D. Grossfeld, Toshiya Manabe, Tetsu Akiyama
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The molecular underpinning of autism is unclear. Here the authors show PX-RICS deficient mice exhibit autism-like social behavioural abnormalities and impaired GABAA receptor trafficking, and enhancing inhibitory synaptic transmission with a GABAArec
Externí odkaz:
https://doaj.org/article/111e3b7f27194d44a435bfedacde52eb
Autor:
Hiroki Takai, Koji Masuda, Tomohiro Sato, Yuriko Sakaguchi, Takeo Suzuki, Tsutomu Suzuki, Ryo Koyama-Nasu, Yukiko Nasu-Nishimura, Yuki Katou, Haruo Ogawa, Yasuyuki Morishita, Hiroko Kozuka-Hata, Masaaki Oyama, Tomoki Todo, Yasushi Ino, Akitake Mukasa, Nobuhito Saito, Chikashi Toyoshima, Katsuhiko Shirahige, Tetsu Akiyama
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 48-60 (2014)
Summary: The development of cancer is driven not only by genetic mutations but also by epigenetic alterations. Here, we show that TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells. Fur
Externí odkaz:
https://doaj.org/article/6e167373836c4249903547f389fae70e
Autor:
Ryo Koyama-Nasu, Rina Takahashi, Satoshi Yanagida, Yukiko Nasu-Nishimura, Masaaki Oyama, Hiroko Kozuka-Hata, Ryo Haruta, Emi Manabe, Akemi Hoshino-Okubo, Hiroko Omi, Nozomu Yanaihara, Aikou Okamoto, Tadao Tanaka, Tetsu Akiyama
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53710 (2013)
The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established
Externí odkaz:
https://doaj.org/article/09ab345a1682412e8371b1e5401c2987
Autor:
Hiroko Kozuka-Hata, Yukiko Nasu-Nishimura, Ryo Koyama-Nasu, Hiroko Ao-Kondo, Kouhei Tsumoto, Tetsu Akiyama, Masaaki Oyama
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43398 (2012)
BACKGROUND: Glioblastoma is one of the most aggressive tumors with poor prognosis. Although various studies have been performed so far, there are not effective treatments for patients with glioblastoma. METHODOLOGY/PRINCIPAL FINDINGS: In order to sys
Externí odkaz:
https://doaj.org/article/c16e55cf7cc94a148a99791c7c0d421d
Autor:
Tetsu Akiyama, Ken Matsuura, Fumika Sakaue, Yasuko Takeda, Tsutomu Nakamura, Yukiko Nasu-Nishimura
Publikováno v:
EBioMedicine
EBioMedicine, Vol 34, Iss, Pp 189-200 (2018)
EBioMedicine, Vol 34, Iss, Pp 189-200 (2018)
GABAergic dysfunction underlies many neurodevelopmental and psychiatric disorders. GABAergic synapses exhibit several forms of plasticity at both pre- and postsynaptic levels. NMDA receptor (NMDAR)–dependent inhibitory long-term potentiation (iLTP)
Autor:
Kanae Echizen, Yasushi Ino, Tetsu Akiyama, Yukiko Nasu-Nishimura, Yasuyuki Morishita, Viviane Tabar, Kosuke Funato, Naomi Shimizu, Lumi Negishi, Ryo Koyama-Nasu, Akitake Mukasa, Nobuhito Saito, Tomoki Todo, Tomoatsu Hayashi
Publikováno v:
EMBO reports. 19
Glioblastoma is one of the most aggressive forms of cancers and has a poor prognosis. Genomewide analyses have revealed that a set of core signaling pathways, the p53, RB, and RTK pathways, are commonly deregulated in glioblastomas. However, the mole
Autor:
R Haruta, Yasushi Ino, E Manabe, M Matsui, Katsuhiko Shirahige, Nobuhito Saito, H Sugano, Kosuke Funato, Yuki Katou, Akitake Mukasa, Kenzui Taniue, Tomoki Todo, A Hoshino-Okubo, Yukiko Nasu-Nishimura, Ryota Takahashi, Tetsu Akiyama, Ryo Koyama-Nasu
Publikováno v:
Oncogene. 33:2236-2244
Increasing evidence suggests that brain tumors arise from the transformation of neural stem/precursor/progenitor cells. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma. Here we show that anaplastic l
Autor:
Sarah N. Mattson, Yasuko Takeda, Tetsu Akiyama, Yukiko Nasu-Nishimura, Natacha Akshoomoff, Toshiya Manabe, Ken Matsuura, Fumiko Arima-Yoshida, Fumika Sakaue, Tsutomu Nakamura, Paul Grossfeld
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Jacobsen syndrome (JBS) is a rare congenital disorder caused by a terminal deletion of the long arm of chromosome 11. A subset of patients exhibit social behavioural problems that meet the diagnostic criteria for autism spectrum disorder (ASD); howev
Autor:
Tomoatsu Hayashi, Ken Matsuura, Susumu Ohwada, Fumika Sakaue, Tetsu Akiyama, Toshio Okabe, Tsutomu Nakamura, Yukiko Nasu-Nishimura
Publikováno v:
Genes to Cells. 12:929-939
In our previous study, we identified RICS, a novel beta-catenin-interacting protein with the GAP activity toward Cdc42 and Rac1, and found that RICS plays an important role in the regulation of neural functions, including postsynaptic NMDA signaling