Výsledky vyhledávání - "Yukiko Matsunaga"

Akademický článek

Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma

Publikováno v: eLife, Vol 9 (2020)

HLA-restricted T cell responses can induce antitumor effects in cancer patients. Previous human T cell research has largely focused on the few HLA alleles prevalent in a subset of ethnic groups. Here, using a panel of newly developed peptide-exchange

Externí odkaz: https://doaj.org/article/d455cc6e68c4440b81ba240acbcb367a

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Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation

Autor: Kenji Murata, Dalam Ly, Hiroshi Saijo, Yukiko Matsunaga, Kenji Sugata, Fumie Ihara, Daisuke Oryoji, Yota Ohashi, Kayoko Saso, Chung-Hsi Wang, Evey Y.F. Zheng, Brian D. Burt, Marcus O. Butler, Naoto Hirano

Publikováno v: The Journal of Immunology. 209:1481-1491

The immunogenicity of a T cell Ag is correlated with the ability of its antigenic epitope to bind HLA and be stably presented to T cells. This presents a challenge for the development of effective cancer immunotherapies, as many self-derived tumor-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a8258c3ce63974dc70958cc51deda9
https://doi.org/10.4049/jimmunol.2200305

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Data from Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy

Autor: Naoto Hirano, Marcus O. Butler, Yota Ohashi, Yukiko Matsunaga, Hiroshi Saijo, Kenji Sugata, Kenji Murata, Chung-Hsi Wang, Mark Anczurowski, Kayoko Saso, Brian Yeung, Tingxi Guo, Yuki Kagoya

Adoptive immunotherapy can induce sustained therapeutic effects in some cancers. Antitumor T-cell grafts are often individually prepared in vitro from autologous T cells, which requires an intensive workload and increased costs. The quality of the ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cb5fb34a5edad3330af3b54055a68c
https://doi.org/10.1158/2326-6066.c.6550458

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Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation

Autor: Masanobu Nagano, Hiroaki Suga, Junichi Takagi, Yukiko Matsunaga, Yan Wu, Nasir K Bashiruddin, Mikihito Hayashi, Tomoki Nakashima

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Osteoporosis affects over 75 million people globally, and this number is increasing with global median age. Therefore, the development of therapeutics with novel mechanisms of action is of high importance. Inhibition of the PlexinB1-Sema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f220681f9bddb3bf933dd8d79fd2bcb5
https://doi.org/10.1073/pnas.2012266117

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Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy

Autor: Yukiko Matsunaga, Mark Anczurowski, Kenji Sugata, Naoto Hirano, Chung-Hsi Wang, Marcus O. Butler, Kayoko Saso, Kenji Murata, Yuki Kagoya, Brian Yeung, Yota Ohashi, Tingxi Guo, Hiroshi Saijo

Publikováno v: Cancer Immunology Research. 8:926-936

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2f6952b50148f1219ef5933695ec64
https://doi.org/10.1158/2326-6066.cir-18-0508

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De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function

Autor: Nozomi Sugano-Nakamura, Kyoko Matoba, Mika Hirose, Nasir K. Bashiruddin, Yukiko Matsunaga, Keitaro Yamashita, Kunio Hirata, Masaki Yamamoto, Takao Arimori, Hiroaki Suga, Junichi Takagi

Publikováno v: Structure. 30:1411-1423.e4

Signaling by single-pass transmembrane receptors often involves a formation of ligand-induced receptor dimers with particular conformation, and bivalent receptor binders can modulate receptor functions by inducing different receptor dimer conformatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a62947ce9857b012cc400fcc26aaf6b
https://doi.org/10.1016/j.str.2022.07.008

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Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells

Autor: Cheryl H. Arrowsmith, Chung-Hsi Wang, Mark Anczurowski, Yuki Kagoya, Kenji Murata, Marcus O. Butler, Naoto Hirano, Yukiko Matsunaga, Tingxi Guo, Hiroshi Saijo, Kayoko Saso, Kenji Sugata

Publikováno v: Journal of Autoimmunity. 97:10-21

Forkhead box transcription factor 3 (FOXP3) plays a pivotal role in the suppressive function of regulatory T cells. In addition to mRNA levels, FOXP3 activity can also be controlled by posttranslational mechanisms, which have not been studied in a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7392e75a43be8b64bf29d0f5d47141
https://doi.org/10.1016/j.jaut.2018.09.011

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Stratum corneum levels of calprotectin proteins S100A8/A9 correlate with disease activity in psoriasis patients

Autor: Akira Ishiko, Yukiko Matsunaga, Yuki Hashimoto

Publikováno v: The Journal of dermatologyREFERENCES. 48(10)

Psoriasis is an intractable inflammatory skin disorder characterized by scaly erythema and plaques. The Psoriasis Area and Severity Index (PASI) is widely used to score disease severity, but evaluation is subjective, and an objective biomarker would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28040f81f9e943e00d3a73afd0694b8
https://pubmed.ncbi.nlm.nih.gov/34165193

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