Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yukiko K. Kaneko"'
Autor:
Megumi Kaji, Yukiko K. Kaneko, Stella Amarachi Ihim, Ran Kanoh, Moe Yamamoto, Momoka Yamaguchi, Tomohisa Ishikawa
Publikováno v:
Frontiers in Nutrition, Vol 10 (2024)
IntroductionNobiletin is a polymethoxyflavonoid abundant in citrus peels and has been reported to have various bioactive effects. We have previously reported that nobiletin inhibits endoplasmic reticulum stress-induced apoptosis in the pancreatic β-
Externí odkaz:
https://doaj.org/article/cefd470eca1545a4bf29a0362286918a
Autor:
Yukiko K. Kaneko, Yuki Tara, Stella Amarachi Ihim, Moe Yamamoto, Megumi Kaji, Tomohisa Ishikawa
Publikováno v:
Phytomedicine Plus, Vol 2, Iss 4, Pp 100367- (2022)
Background: Nobiletin, a polymethoxy flavone contained in the peel of Citrus reticulata, has been known to have health benefits especially those related to improvement of type 2 diabetes. Our previous in vitro study demonstrated the insulinotropic an
Externí odkaz:
https://doaj.org/article/1f45d57433f343509be7c2f6f45b2511
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 178-186 (2019)
The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a
Externí odkaz:
https://doaj.org/article/84a0827a13314c359af2bf0f6ff72b90
Autor:
Miki Takii, Yukiko K. Kaneko, Kiriko Akiyama, Yuki Aoyagi, Yuki Tara, Tomohiro Asakawa, Makoto Inai, Toshiyuki Kan, Kiyomitsu Nemoto, Tomohisa Ishikawa
Publikováno v:
Journal of Functional Foods, Vol 30, Iss , Pp 8-15 (2017)
To determine the mechanism underlying anti-diabetic effects of nobiletin, a citrus flavonoid, the effects of nobiletin on insulin secretion and β-cell apoptosis were investigated in the INS-1D β-cell line. Nobiletin increased glucose-induced insuli
Externí odkaz:
https://doaj.org/article/91b3ad4fe08049fdb9a19d4f12a61850
Autor:
Yukiko K. Kaneko
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:640-646
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fc219d31b4ec7bfbff06fe096d78987
https://doi.org/10.1248/bpb.b22-00928
https://doi.org/10.1248/bpb.b22-00928
Autor:
Stella Amarachi Ihim, Yukiko K. Kaneko, Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 46:630-635
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9bbae7e6f60962f762053200a3747a5
https://doi.org/10.1248/bpb.b22-00913
https://doi.org/10.1248/bpb.b22-00913
Autor:
Yukiko K. Kaneko, Ami Morioka, Misaki Sano, Maho Tashiro, Naoya Watanabe, Nahoko Kasahara, Masato Nojiri, Chihiro Ishiwatari, Kentaro Ichinose, Akira Minami, Takashi Suzuki, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikawa
Publikováno v:
Biochemical and Biophysical Research Communications. 637:108-116
Low concentrations of nitric oxide (NO) produced by constitutive NO synthase (cNOS) has been shown to suppress apoptosis in pancreatic β-cells. In the present study, the influence of asymmetric dimethylarginine (ADMA), the major endogenous inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5900e3337fc929967f440cb20871fa
https://doi.org/10.1016/j.bbrc.2022.11.011
https://doi.org/10.1016/j.bbrc.2022.11.011
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(5)
Depression of lipid metabolism in β-cells has been indicated to be one of the causes of impaired insulin secretion in type 2 diabetes. Diacylglycerol (DAG) is an important lipid mediator and is known to regulate insulin secretion in pancreatic β-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174479d0e9e5e3a7a10fc6f134aad1e5
https://pubmed.ncbi.nlm.nih.gov/35491149
https://pubmed.ncbi.nlm.nih.gov/35491149
Autor:
Momoka Yamaguchi, Saya Ohbayashi, Akira Ooka, Hinako Yamashita, Nanami Motohashi, Yukiko K. Kaneko, Toshihide Kimura, Shin-ya Saito, Tomohisa Ishikawa
Publikováno v:
Biochemical and biophysical research communications. 600
Liver fibrosis is a major consequence of chronic liver disease, where excess extracellular matrix is deposited, due caused by the activation of hepatic stellate cells (HSCs). The suppression of collagen production in HSCs is therefore regarded as a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9b33cdecf22ffd3f1c9a3c01fe6529
https://pubmed.ncbi.nlm.nih.gov/35219102
https://pubmed.ncbi.nlm.nih.gov/35219102
Publikováno v:
Biologicalpharmaceutical bulletin. 38(10)
Our previous study using apoptosis analysis suggested that Ca(2+) release through inositol 1,4,5-trisphosphate (IP3) receptors and the subsequent Ca(2+) influx through store-operated channels (SOCs) constitute a triggering signal for H2O2-induced β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4fa0baf7c141d3f1cd158be2fef1dbe
https://pubmed.ncbi.nlm.nih.gov/26424020
https://pubmed.ncbi.nlm.nih.gov/26424020