Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Yukiko Hori"'
Autor:
Kei Oyama, Kei Majima, Yuji Nagai, Yukiko Hori, Toshiyuki Hirabayashi, Mark A. G. Eldridge, Koki Mimura, Naohisa Miyakawa, Atsushi Fujimoto, Yuki Hori, Haruhiko Iwaoki, Ken-ichi Inoue, Richard C. Saunders, Masahiko Takada, Noriaki Yahata, Makoto Higuchi, Barry J. Richmond, Takafumi Minamimoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Primates must adapt to changing environments by optimizing their behavior to make beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choice value through direct experience or kn
Externí odkaz:
https://doaj.org/article/f27f8d73cd764fdea074b296a315d225
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Temporal discounting, in which the recipient of a reward perceives the value of that reward to decrease with delay in its receipt, is associated with impulsivity and psychiatric disorders such as depression. Here, we investigate the role of
Externí odkaz:
https://doaj.org/article/49c7bf42b78340898ae30e79830cdb12
Autor:
Toshiyuki Hirabayashi, Yuji Nagai, Yuki Hori, Yukiko Hori, Kei Oyama, Koki Mimura, Naohisa Miyakawa, Haruhiko Iwaoki, Ken-ichi Inoue, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Visual object memory is a fundamental element of various cognitive abilities, and the underlying neural mechanisms have been extensively examined especially in the anterior temporal cortex of primates. However, both macroscopic large-scale f
Externí odkaz:
https://doaj.org/article/02803be30c1241b9a4827729b6309ee6
Autor:
Masahiro Furuta, Suguru Arii, Hiroki Umeda, Ryota Matsukawa, Katsuyuki Shizu, Hironori Kaji, Shigehiro A. Kawashima, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Harunobu Mitsunuma, Motomu Kanai
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Aberrant aggregates of amyloid‐β (Aβ) and tau protein (tau), called amyloid, are related to the etiology of Alzheimer disease (AD). Reducing amyloid levels in AD patients is a potentially effective approach to the treatment of AD. The se
Externí odkaz:
https://doaj.org/article/3a27e950c08646478461fff6e10930c9
Autor:
Kei Kimura, Yuji Nagai, Gaku Hatanaka, Yang Fang, Soshi Tanabe, Andi Zheng, Maki Fujiwara, Mayuko Nakano, Yukiko Hori, Ryosuke F. Takeuchi, Mikio Inagaki, Takafumi Minamimoto, Ichiro Fujita, Ken-ichi Inoue, Masahiko Takada
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Recent emphasis has been placed on gene transduction mediated through recombinant adeno-associated virus (AAV) vector to manipulate activity of neurons and their circuitry in the primate brain. In the present study, we created a novel vector
Externí odkaz:
https://doaj.org/article/7b83bed180794f949a1117f5ec0d435f
Autor:
Yukiko Hori, Koki Mimura, Yuji Nagai, Yuki Hori, Katsushi Kumata, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimoto
Publikováno v:
PLoS Biology, Vol 22, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/12f6601302134a079b11829471a19d44
Autor:
Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Pharmacological and surgical treatments of epilepsy can have unsatisfactory outcomes, so a more targeted and on-demand approach is desirable. Here, the authors demonstrate the usage of inhibitory chemogenetics in male nonhuman primates to attenuate t
Externí odkaz:
https://doaj.org/article/134aeee71b1746ecb0a7efa80a5b5681
Autor:
Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106375- (2023)
Summary: The genetic associations of TREM2 loss-of-function variants with Alzheimer disease (AD) indicate the protective roles of microglia in AD pathogenesis. Functional deficiencies of TREM2 disrupt microglial clustering around amyloid β (Aβ) pla
Externí odkaz:
https://doaj.org/article/af25ed148e4b4927a09a4767c158f8d4
Publikováno v:
Neuroscience Insights, Vol 17 (2022)
Alzheimer’s disease (AD) is characterized by the aggregation and deposition of 2 amyloid proteins: amyloid β peptide (Aβ) and tau protein. Immunotherapies using anti-Aβ antibodies to promote the clearance of aggregated Aβ have recently been hig
Externí odkaz:
https://doaj.org/article/e8db6bf7234449d4a4589e2a3286ec26
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer disease (AD) is associated with the aggregation of two amyloid proteins: tau and amyloid-β (Aβ). The results of immunotherapies have shown that enhancing the clearance and suppressing the aggregation of these two proteins are effective th
Externí odkaz:
https://doaj.org/article/e983fcaa52c349e3a82d4322edc9fde9