Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yukiko Hikichi"'
Autor:
Hiroya Taniguchi, Yuji Baba, Yoji Sagiya, Masamitsu Gotou, Kazuhide Nakamura, Hiroshi Sawada, Kazunori Yamanaka, Yukiko Sakakibara, Ikuo Mori, Yukiko Hikichi, Junpei Soeda, Hideo Baba
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 668-677 (2018)
Recent studies in RAS wild-type (WT) metastatic colorectal cancer (mCRC) suggest that the survival benefits of therapy using anti-epidermal growth factor receptor (anti-EGFR) and anti-vascular endothelial growth factor (anti-VEGF) antibodies combined
Externí odkaz:
https://doaj.org/article/10a652df2cb74644a94811edf9be7359
Autor:
Megumi Morimoto, Yuichiro Amano, Masahiro Oka, Ayako Harada, Hisashi Fujita, Yukiko Hikichi, Ryuichi Tozawa, Masuo Yamaoka, Takahito Hara
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189480 (2017)
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators
Externí odkaz:
https://doaj.org/article/ec8c979a56754538966755b08345e3ca
Autor:
Masamitsu Gotou, Hideo Baba, Yuji Baba, Yoji Sagiya, Junpei Soeda, Hiroshi Sawada, Yukiko Hikichi, Hiroya Taniguchi, Kazuhide Nakamura, Ikuo Mori, Kazunori Yamanaka, Yukiko Sakakibara
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 668-677 (2018)
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 668-677 (2018)
Recent studies in RAS wild-type (WT) metastatic colorectal cancer (mCRC) suggest that the survival benefits of therapy using anti-epidermal growth factor receptor (anti-EGFR) and anti-vascular endothelial growth factor (anti-VEGF) antibodies combined
Publikováno v:
European Journal of Pharmacology. 765:322-331
Selective androgen receptor modulators (SARMs) specifically bind to the androgen receptor and exert agonistic or antagonistic effects on target organs. In this study, we investigated the SARM activity of TSAA-291, previously known as a steroidal anti
Autor:
Yuichiro Amano, Yukiko Hikichi, Ryuichi Tozawa, Ayako Harada, Masahiro Oka, Masuo Yamaoka, Megumi Morimoto, Hisashi Fujita, Takahito Hara
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189480 (2017)
PLoS ONE, Vol 12, Iss 12, p e0189480 (2017)
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators
Autor:
Koji Ono, Yukiko Hikichi, Masanori Okaniwa, Douglas R. Cary, Maki Hasegawa, Kazunobu Aoyama, Hiroshi Banno, Saomi Murai, Kazuko Yonemori, Yuka Hasegawa, Akito Hata, Takaharu Hirayama, Naoki Iwamura
Publikováno v:
Bioorganicmedicinal chemistry. 25(8)
To develop a novel series of CDK8/19 dual inhibitors, we employed structure-based drug design using docking models based on a library compound, 4,5-dihydroimidazolo[3',4':3,4]benzo[1,2-d]isothiazole 16 bound to CDK8. We designed various [5,6,5]-fused
Autor:
Douglas R. Cary, Kazunobu Aoyama, Yuka Hasegawa, Yasuhiro Hirata, Jun Fujimoto, Kazuko Yonemori, Takaharu Hirayama, Akito Hata, Yukiko Hikichi, Maki Hasegawa, Saomi Murai
Publikováno v:
Bioorganicmedicinal chemistry. 25(12)
In this article, synthetic studies around a pyridylacrylamide-based hit compound (1), utilizing structure-based drug design guided by CDK8 docking models, is discussed. Modification of the pendant 4-fluorophenyl group to various heteroaromatic rings
Autor:
Shinji Takagi, Toshiyuki Nomura, Kanae Gamo, Matsumoto Satoru, Ryujiro Hara, Hitoshi Miyashita, Ken Tsuchida, Yukiko Hikichi, Shinichi Imamura, Kazuhide Nakamura, Masato Yabuki, Akiko Nakayama, Yoshinori Ishikawa, Kazuhide Nakayama, Misa Iwatani, Megumi Morimoto, Daisuke Tomita, Naoki Tomita, Yusuke Kamada, Kosei Toyoshima, Ryo Dairiki
Publikováno v:
Molecular cancer therapeutics. 16(2)
Dysregulation of lysine (K)-specific demethylase 1A (LSD1), also known as KDM1A, has been implicated in the development of various cancers, including leukemia. Here, we describe the antileukemic activity and mechanism of action of T-3775440, a novel
Publikováno v:
Journal of Biological Chemistry. 277:50054-50061
LIGHT is a member of tumor necrosis factor (TNF) superfamily, and its receptors have been identified as lymphotoxin-beta receptor (LTbetaR) and the herpesvirus entry mediator (HVEM)/ATAR/TR2, both of which lack the cytoplasmic sequence termed the "de
The ubiquitin–proteasome pathway is a major protein degradation pathway whose dysfunction is now widely accepted as a cause of neurodegenerative diseases, including Alzheimer's disease. Here we demonstrate that the F-box and leucine rich repeat pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622cdc9156bf415c4668bc09ea8e73b1
https://europepmc.org/articles/PMC6621050/
https://europepmc.org/articles/PMC6621050/