Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Yukihiro Yabuta"'
Autor:
Keisuke Toriyama, Wan Kin Au Yeung, Azusa Inoue, Kazuki Kurimoto, Yukihiro Yabuta, Mitinori Saitou, Toshinobu Nakamura, Toru Nakano, Hiroyuki Sasaki
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Genome-wide DNA demethylation occurs in mammalian primordial germ cells (PGCs) as part of the epigenetic reprogramming important for gametogenesis and resetting the epigenetic information for totipotency. Dppa3 (also known as Stel
Externí odkaz:
https://doaj.org/article/00e65864e7a743a1982400d04bcbce0c
Autor:
Shihori Yokobayashi, Yukihiro Yabuta, Masato Nakagawa, Keisuke Okita, Bo Hu, Yusuke Murase, Tomonori Nakamura, Guillaume Bourque, Jacek Majewski, Takuya Yamamoto, Mitinori Saitou
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109909- (2021)
Summary: Human induced pluripotent stem cells (hiPSCs) show variable differentiation potential due to their epigenomic heterogeneity, whose extent/attributes remain unclear, except for well-studied elements/chromosomes such as imprints and the X chro
Externí odkaz:
https://doaj.org/article/ede168a2bf544c0b9ef86da849b5f0a5
Autor:
Kotaro Sasaki, Akiko Oguchi, Keren Cheng, Yasuhiro Murakawa, Ikuhiro Okamoto, Hiroshi Ohta, Yukihiro Yabuta, Chizuru Iwatani, Hideaki Tsuchiya, Takuya Yamamoto, Yasunari Seita, Mitinori Saitou
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109075- (2021)
Summary: In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal organiz
Externí odkaz:
https://doaj.org/article/e61a3b1420ab4cfe9366c4029984c419
Autor:
Sayuri Gyobu‐Motani, Yukihiro Yabuta, Ken Mizuta, Yoshitaka Katou, Ikuhiro Okamoto, Masanori Kawasaki, Ayaka Kitamura, Tomoyuki Tsukiyama, Chizuru Iwatani, Hideaki Tsuchiya, Taro Tsujimura, Takuya Yamamoto, Tomonori Nakamura, Mitinori Saitou
Publikováno v:
The EMBO Journal. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::426a940e96747eb039a9c3775916b20e
https://doi.org/10.15252/embj.2022112962
https://doi.org/10.15252/embj.2022112962
Autor:
Serena F. Generoso, Maria Victoria Neguembor, Elliot A. Hershberg, Ruslan I. Sadreyev, Kazuki Kurimoto, Yukihiro Yabuta, Raffaele Ricci, Pauline Audergon, Moritz Bauer, Mitinori Saitou, Konrad Hochedlinger, Brian J. Beliveau, Maria Pia Cosma, Jeannie T. Lee, Bernhard Payer
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Reactivation of the inactive X chromosome is a hallmark epigenetic event during reprogramming of mouse female somatic cells to induced pluripotent stem cells (iPSCs). This involves global structural remodeling from a condensed, heterochromatic into a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398ec0602c9b6ed458b11701a7903b5a
https://doi.org/10.1073/pnas.2213810120
https://doi.org/10.1073/pnas.2213810120
Autor:
Yusuke Imoto, Tomonori Nakamura, Emerson G Escolar, Michio Yoshiwaki, Yoji Kojima, Yukihiro Yabuta, Yoshitaka Katou, Takuya Yamamoto, Yasuaki Hiraoka, Mitinori Saitou
Publikováno v:
Life Science Alliance. 5(12)
Single-cell RNA sequencing (scRNA-seq) can determine gene expression in numerous individual cells simultaneously, promoting progress in the biomedical sciences. However, scRNA-seq data are high-dimensional with substantial technical noise, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead2fe8f6e355f9e52f368310ff087b0
http://hdl.handle.net/2433/275925
http://hdl.handle.net/2433/275925
Autor:
Ken Mizuta, Yoshitaka Katou, Baku Nakakita, Aoi Kishine, Yoshiaki Nosaka, Saki Saito, Chizuru Iwatani, Hideaki Tsuchiya, Ikuo Kawamoto, Masataka Nakaya, Tomoyuki Tsukiyama, Masahiro Nagano, Yoji Kojima, Tomonori Nakamura, Yukihiro Yabuta, Akihito Horie, Masaki Mandai, Hiroshi Ohta, Mitinori Saitou
Publikováno v:
The EMBO Journal. 41(18)
In vitro oogenesis is key to elucidating the mechanism of human female germ-cell development and its anomalies. Accordingly, pluripotent stem cells have been induced into primordial germ cell-like cells and into oogonia with epigenetic reprogramming,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8dc4e214a524ccf37b474df333eabd
http://hdl.handle.net/2433/282100
http://hdl.handle.net/2433/282100
Nucleome programming is required for the foundation of totipotency in mammalian germline development
Autor:
Masahiro Nagano, Bo Hu, Shihori Yokobayashi, Akitoshi Yamamura, Fumiya Umemura, Mariel Coradin, Hiroshi Ohta, Yukihiro Yabuta, Yukiko Ishikura, Ikuhiro Okamoto, Hiroki Ikeda, Naofumi Kawahira, Yoshiaki Nosaka, Sakura Shimizu, Yoji Kojima, Ken Mizuta, Tomoko Kasahara, Yusuke Imoto, Killian Meehan, Roman Stocsits, Gordana Wutz, Yasuaki Hiraoka, Yasuhiro Murakawa, Takuya Yamamoto, Kikue Tachibana, Jan‐Michel Peters, Leonid A Mirny, Benjamin A Garcia, Jacek Majewski, Mitinori Saitou
Publikováno v:
EMBO J
Germ cells are unique in engendering totipotency, yet the mechanisms underlying this capacity remain elusive. Here, we perform comprehensive and in‐depth nucleome analysis of mouse germ‐cell development in vitro, encompassing pluripotent precurso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5ca487803e03f24dcf44ae893eb908
https://pubmed.ncbi.nlm.nih.gov/35703121
https://pubmed.ncbi.nlm.nih.gov/35703121
Autor:
Hideaki Tsuchiya, Kotaro Sasaki, Takuya Yamamoto, Ikuhiro Okamoto, Shinichiro Nakamura, Chizuru Iwatani, Masatsugu Ema, Tomonori Nakamura, Mitinori Saitou, Yukihiro Yabuta
Publikováno v:
Science. 374
X chromosome dosage compensation ensures balanced gene dosage between the X chromosome and autosomes and between the sexes, involving divergent mechanisms among mammals. We elucidated a distinct mechanism for X chromosome inactivation (XCI) in cynomo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53711edbf650fe491b4c1f604cf69c64
https://doi.org/10.1126/science.abd8887
https://doi.org/10.1126/science.abd8887
Autor:
Yasuhiro Murakawa, Takuya Yamamoto, Yukihiro Yabuta, Ikuhiro Okamoto, Mitinori Saitou, Akiko Oguchi, Chizuru Iwatani, Hiroshi Ohta, Kotaro Sasaki, Keren Cheng, Yasunari Seita, Hideaki Tsuchiya
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109075-(2021)
Summary: In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal organiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456ec21153974b9427d4777c97b95f47
http://www.sciencedirect.com/science/article/pii/S221112472100406X
http://www.sciencedirect.com/science/article/pii/S221112472100406X