Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yukihiro Tateishi"'
Autor:
Ryunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, Takashi Ishida, Daniel Ken Inaoka, Yasushi Amano, Yukihiro Tateishi, Kazuki Ohno, Ichiji Namatame, Tatsuya Niimi, Masaya Orita, Kiyoshi Kita, Yutaka Akiyama, Masakazu Sekijima
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Chagas disease results from infection by Trypanosoma cruzi and is a neglected tropical disease (NTD). Although some treatment drugs are available, their use is associated with severe problems, including adverse effects and limited effectiven
Externí odkaz:
https://doaj.org/article/9864fe2ce67f43499bde2b3251ec52d6
Autor:
Daniel Ken Inaoka, Masakazu Sekijima, Takashi Ishida, Yutaka Akiyama, Masaya Orita, Kiyoshi Kita, Yukihiro Tateishi, Ryunosuke Yoshino, Tatsuya Niimi, Yohsuke Hagiwara, Kazuki Ohno, Ichiji Namatame, Yasushi Amano, Nobuaki Yasuo
Background Chagas disease is caused by the parasite Trypanosoma cruzi and is one of the neglected tropical diseases. Although two types of drugs are currently available, new drugs are still required because they have serious side effects. To develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cd2fda5448f2fe1c6d1d106de6a02a
https://doi.org/10.26434/chemrxiv-2021-qk2ns
https://doi.org/10.26434/chemrxiv-2021-qk2ns
Autor:
Yukihiro Tateishi, Yutaka Kondoh, Yoshinori Iwai, Hiroyuki Moritomo, Hiroyuki Hisamichi, Shigetoshi Kikuchi, Masaaki Hirano, Minoru Kameda, Yuka Echizen, Kazuhiko Iikubo, Taisuke Nakazawa, Hiroshi Tomiyama, Yasushi Amano, Yuichiro Kawamoto, Tadashi Terasaka, Ikumi Kuriwaki, Atsushi Noda
Publikováno v:
Bioorganic & Medicinal Chemistry. 33:116019
Fibroblast growth factor receptor 3 (FGFR3) is an attractive therapeutic target for the treatment of patients with bladder cancer harboring genetic alterations in FGFR3. We identified pyrimidine derivative 20b, which induced tumor regression followin
Autor:
Osamu Tani, Tatsuya Niimi, Yukihiro Tateishi, Kazuhiko Yamasaki, Koji Furukawa, Hitoshi Sakashita, Ichiji Namatame, Eiki Tanabe
Publikováno v:
Journal of Medicinal Chemistry. 59:2261-2266
Although NMR in fragment-based drug discovery is utilized almost exclusively to evaluate physical binding between molecules, it should be also a powerful tool for biochemical assay, evaluating inhibitory effect of compounds on enzymatic activity. Tim
Autor:
Shigetoshi Kikuchi, Yoshinori Iwai, Ikumi Kuriwaki, Masaaki Hirano, Yasushi Amano, Atsushi Noda, Yukihiro Tateishi, Yuichiro Kawamoto, Kazuhiko Iikubo, Minoru Kameda, Hiroyuki Moritomo, Hiroshi Tomiyama, Yuka Echizen, Tomoyuki Suzuki, Hiroyuki Hisamichi, Yutaka Kondoh
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115453
Fibroblast growth factor receptor 3 (FGFR3) is an attractive therapeutic target for the treatment of bladder cancer. We identified 1,3,5-triazine derivative 18b and pyrimidine derivative 40a as novel structures with potent and highly selective FGFR3
Autor:
Shusaku Mizukami, Osamu Tani, Yukihiro Tateishi, Kazuhiko Yamasaki, Takayuki Suzuki, Tatsuya Niimi, Yukie Akutsu, Tetsuo Yanagi, Tomomi Kubota, Shinji Ito, Ichiji Namatame, Tomohiko Yamaguchi, Yasunori Chiba, Koji Furukawa, Kenji Hirayama, Hitoshi Sakashita
Publikováno v:
Journal of medicinal chemistry. 61(11)
Oxidosqualene cyclase (OSC), a membrane-associated protein, is a key enzyme of sterol biosynthesis. Here we report a novel assay for OSC, involving reaction in aqueous solution, NMR quantification in organic solvent, and factor analysis of spectra. W
Autor:
Hitoshi Sakashita, Yukihiro Tateishi, Tatsuya Niimi, Yasushi Amano, Ichiji Namatame, Kazuya Honboh, Eiki Tanabe
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 71:1879-1889
Trypanosoma cruzicauses Chagas disease, a severe disease affecting 8–10 million people in Latin America. While nifurtimox and benznidazole are used to treat this disease, their efficacy is limited and adverse effects are observed. New therapeutic t
Autor:
Yukihiro Tateishi, Daniel Ken Inaoka, Kiyoshi Kita, Takashi Ishida, Yutaka Akiyama, Ichiji Namatame, Kazuki Ohno, Tatsuya Niimi, Yohsuke Hagiwara, Masakazu Sekijima, Masaya Orita, Ryunosuke Yoshino, Nobuaki Yasuo, Yasushi Amano
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports
Chagas disease results from infection by Trypanosoma cruzi and is a neglected tropical disease (NTD). Although some treatment drugs are available, their use is associated with severe problems, including adverse effects and limited effectiveness durin
Autor:
Osamu Tani, Yukie Akutsu, Shinji Ito, Takayuki Suzuki, Yukihiro Tateishi, Tomohiko Yamaguchi, Tatsuya Niimi, Ichiji Namatame, Yasunori Chiba, Hitoshi Sakashita, Tomomi Kubota, Tetsuo Yanagi, Shusaku Mizukami, Kenji Hirayama, Koji Furukawa, Kazuhiko Yamasaki
Publikováno v:
Journal of Medicinal Chemistry. 61:6399-6399
Autor:
Toshimichi Fujiwara, Masahiro Shirakawa, Yukihiro Tateishi, Nobuyasu Komi, Kayo Okawa, Hideo Akutsu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768:3001-3011
PACAP (pituitary adenylate cyclase-activating polypeptide) is a member of the VIP/secretin/glucagon family, which includes the ligands of class II G-protein coupled receptors. Since the recognition of PACAP by the receptor may involve the binding of