Výsledky vyhledávání - "Yukihiro Kuroda"

The present state of studies on attractive and amphiphilic multi-functional methylated β-cyclodextrins and their purity measurements

Autor: Toshiko Tanimoto, Ryohei Hamaguchi, Madoka Kimura, Keiji Terao, Yukihiro Kuroda, Chie Honda

Publikováno v: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 95:285-293

β-Cyclodextrins (β-CD) are widely used in multiple fields such as medicine, agriculture, alimentation, and cosmetics because their hydrophobic cavity enables the formation of inclusion complexes with various organic compounds to improve their perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05e8917a15d862388169796cf59fe871
https://doi.org/10.1007/s10847-019-00943-5

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The Limited Contribution of the Analyte Partition to the Water-Rich Layer in Immobilized Artificial Membrane Chromatography with an Acetonitrile-Rich Binary Mobile Phase

Autor: Yukihiro Kuroda, Haruka Okamoto, Ryohei Hamaguchi, Yoshie Iwakuma

Publikováno v: Chromatographia. 82:1311-1320

Drug-induced phospholipidosis, a side effect of drugs, is associated with drug–membrane binding. Hydrophobic interactions of the drug with the membrane and polar interactions of the drug with the membrane are involved. For risk predictions, membran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::244805887b57aa8af8e7bf5cb16333da
https://doi.org/10.1007/s10337-019-03750-9

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Hydrophilic interaction chromatography with a focus on the drug–phosphate interaction in drug screening to determine the phospholipidosis induction risk

Autor: Yukihiro Kuroda, Ryohei Hamaguchi, Haruka Okamoto

Publikováno v: Journal of Chromatography B. 1051:33-40

Cationic amphiphilic drugs (CADs) can induce the hyperaccumulation of phospholipids in cells and tissues. This side effect, which is known as drug-induced phospholipidosis, is sometimes problematic in the development and clinical use of CADs. It is k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d89d28564ff5c8105b07726e8409c
https://doi.org/10.1016/j.jchromb.2017.02.024

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A Novel Biomarker for Cellular Toxicity and Phospholipid Accumulation by Cationic Amphiphilic Drugs

Autor: Yukihiro Kuroda, Ryohei Hamaguchi

Publikováno v: CHROMATOGRAPHY. 37:35-38

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f294c48cb8a1469360b7a9e739d8668
https://doi.org/10.15583/jpchrom.2015.033

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Maintenance of luminal pH and protease activity in lysosomes/late endosomes by vacuolar ATPase in chlorpromazine-treated RAW264 cells accumulating phospholipids

Autor: Toshiko Tanimoto, Ryohei Hamaguchi, Jun Haginaka, Yukihiro Kuroda

Publikováno v: Cell Biology and Toxicology. 30:67-77

Cationic amphiphilic drugs (CADs) inhibit phospholipases competitively/uncompetitively. It has also been reported that CADs spontaneously accumulate in acidic organelles and increase their luminal pH, which may lead to deactivation of phospholipid-me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599b0a20db85e51b8e37f098498e1bde
https://doi.org/10.1007/s10565-014-9269-2

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Phospholipid-Modified ODS Monolithic Column for Affinity Prediction of Hydrophobic Basic Drugs to Phospholipids

Autor: Yukihiro Kuroda, Toshiko Tanimoto, Ryohei Hamaguchi

Publikováno v: Chromatographia. 77:405-411

A phospholipid-modified octadecyl silica (ODS) monolithic column was prepared and its interaction with basic hydrophobic drugs was studied. These drugs are of interest in pharmaceutical research because of their strong interaction with biomembranes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::205cce357e28d9cf94d973097d21aaea
https://doi.org/10.1007/s10337-013-2621-5

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Role of bis(monoacylglycero)phosphate in propranolol binding to phospholipid membranes under acidic conditions as measured by high-performance frontal analysis/capillary electrophoresis

Autor: Jun Haginaka, Toshiko Tanimoto, Ryohei Hamaguchi, Yukihiro Kuroda

Publikováno v: ELECTROPHORESIS. 33:3101-3106

Bis(monoacylglycero)phosphate (BMP) is localized in acidic organelles such as late endosomes or lysosomes. It has been reported that BMP levels increase under phospholipidosis induced by cationic amphiphilic drugs. In the present study, the effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4800958e476a6b10f5e4c5d0bfb3af76
https://doi.org/10.1002/elps.201200324

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On-line capillary isoelectric focusing–mass spectrometry for quantitative analysis of peptides and proteins

Autor: Hideo Yukinaga, Terumichi Nakagawa, Taeko Noguchi, Katsumi Matsuzaki, Akimasa Shibukawa, Mahboob Nemati, Yukihiro Kuroda, Masahiro Kitano

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 37:423-428

On-line capillary isoelectric focusing-mass spectrometry (cIEF-MS) was applied to determine concentrations of peptides and proteins using angiotensin II and human tetrasialo-transferrin as the model samples. The concentration of the carrier ampholyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cfa19b768b2b95ed83d8f578049bdc
https://doi.org/10.1016/j.jpba.2004.11.025

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