Výsledky vyhledávání - "Yukihiro Kuge"

Chemoenzymatic synthesis of four diastereomers of (6-fluoro-2-chromanyl) oxirane: An intermediate of a potent β-blocker

Autor: Kenichi Mochida, Akira Horiguchi, Yukihiro Kuge

Publikováno v: Journal of Molecular Catalysis B: Enzymatic. 3:285-292

The synthesis of optically active 5-acetoxy-3-(p-fluorophenoxy)-1-pentanol 4, for the synthesis of the potent β-blocker R-67555, bis[2-(2-chromanyl-6-fluoro)-2-hydroxyethyl]amine 1, was investigated. The acetylation of 3-(p-fluorophenoxy)-1,5-pentan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78999385cec797281320d7ce15ffb795
https://doi.org/10.1016/s1381-1177(97)00013-1

Zobrazit plný text záznamu

Large-scale chemoenzymic synthesis of calcium (6S)-5-formyl-5,6,7,8-tetrahydrofolate [(–)-leucovorin] using the NADPH recycling method

Autor: Shinji Tomioka, Yukihiro Kuge, Katsuhiko Ando, Takayuki Uwajima, Tamotsu Eguchi, Junji Kanazawa, Masami Okabe, Kunimi Inoue, Takashi Oshiro, Toru Sugaya, Kenichi Mochida

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1427-1431

Chemoenzymic large-scale synthesis of the calcium salt of (6S)-5-formyltetrahydrofolic acid [(–)-leucovorin, (6S)-5] was achieved from folic acid 1via(6S)-tetrahydrofolic acid [(6S)-3] by using dihydrofolate reductase (DHFR) produced by Escherichia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8543dac150cc7d552fd366f084e00807
https://doi.org/10.1039/p19940001427

Zobrazit plný text záznamu

Enzymatic Optical Resolution of Dibenzoxepins and Its Application to an Optically Active Antiallergic Agent with Thromboxane A2Receptor Antagonistic Activity

Autor: Yukihiro Kuge, Kenji Shioga, Shinji Tomioka, Toru Sugaya

Publikováno v: Bioscience, Biotechnology, and Biochemistry. 57:1157-1160

Methyl (+/-)-11-(2-hydroxyethyl)thio-6,11-dihydrodibenz[b,e]oxepin- 2- carboxylate (5) was enantio-selectively acylated with acetic anhydride in an organic medium by Lipase Amano P to give methyl (-)-11-(2-acetoxyethyl)thio-6,11-dihydrodibenz[b,e]oxe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00e16384ba92e32b02e033b52c17b12
https://doi.org/10.1271/bbb.57.1157

Zobrazit plný text záznamu

ChemInform Abstract: A Facile Synthesis of 5-Phenylimidazo(4,5-c)(1,8)naphthyridin-4(5H)- one

Autor: Toru Sugaya, Yukihiro Kuge, Nobuyuki Kato, Shinji Tomioka

Publikováno v: ChemInform. 26

1-Phenyl-3-nitroso-4-amino-1,8-naphthyridin-2(1H)-one (9) was prepared on a large scale and was converted to 5-phenyl-imidazo[4,5-c] [1,8]naphthyridin-4(5H)-one (KF17625, 1) which exhibits potent antiasthmatic activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8736ee7cc7f4d2d0e6911984b70aa1ab
https://doi.org/10.1002/chin.199519153

Zobrazit plný text záznamu

ChemInform Abstract: A Facile One-Pot Synthesis of Vinpocetine (I)

Autor: Shinji Tomioka, T. Kometani, Yukihiro Kuge, H. Nakazawa, Toru Sugaya, Kenichi Mochida

Publikováno v: ChemInform. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3523bd5f8b05676b53d733b33dc09bef
https://doi.org/10.1002/chin.199447245

Zobrazit plný text záznamu

ChemInform Abstract: Facile and Efficient Synthesis of 7,10-Dihydroxy-6H-pyrazolo(4,5,1-de) acridin-6-one via Hypervalent Iodine Oxidation

Autor: Shinji Tomioka, Takashi Mimura, Sachiko Kato, Toru Sugaya, Masanori Ikuta, Nobuyuki Kato, Masaji Kasai, Yukihiro Kuge

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55bda5ebe4ff65dd67e72c7cd86fe59f
https://doi.org/10.1002/chin.199746154

Zobrazit plný text záznamu

ChemInform Abstract: An Efficient Synthesis of a New Class of DNA Intercalating Antitumor 7,10-Dihydroxy-6H-pyrazolo[4,5,1-de]acridin-6-ones

Autor: Sachiko Kato, Shinji Tomioka, Toru Sugaya, Masanori Ikuta, Nobuyuki Kato, Takashi Mimura, Yukihiro Kuge, Masaji Kasai

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88eaad9f64a1aab1cb42143333d20e8c
https://doi.org/10.1002/chin.199936173

Zobrazit plný text záznamu

Microbial hydroxylation of 2-phenylpropionic acid

Autor: Kenichi Mochida, Yukihiro Kuge, Takayuki Uwajima

Publikováno v: Agricultural and Biological Chemistry. 55:1099-1104

The hydroxylation of 2-phenylpropionic acid (PPH) to 2-(p-hydroxyphenyl)propionic acid (HPPH) was investigated using various microorganisms. The highest hydroxylating activity was found in Streptomyces rimosus ATCC 10907. The reaction product was iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f3e47f22b30d48fb244f07a92b8211
https://doi.org/10.1271/bbb1961.55.1099

Zobrazit plný text záznamu

Chemo-enzymatic synthesis of optically pure l-leucovorin, an augmentor of 5-fluorouracil cytotoxicity against cancer

Autor: Takashi Oshiro, Masanori Iwakura, Kenichi Mochida, Akiko Igarashi, Takayuki Uwajima, Tamotsu Eguchi, Akira Horiguchi, Yukihiro Kuge

Publikováno v: Biochemical and Biophysical Research Communications. 171:684-689

Optically pure l-leucovorin was synthesized on a large scale by the combination of chemical and enzymatic processes. After reduction of folate with zinc, dihydrofolate was reduced asymmetrically to (6)-tetra-hydrofolate by use of dihydrofolate reduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fe3002b62384c72ccf5886c21fd499
https://doi.org/10.1016/0006-291x(90)91200-c

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání