Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yukihiro Eguchi"'
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101333 (2014)
A massive integrative mathematical model of DNA double-strand break (DSB) generation, DSB repair system, p53 signaling network, and apoptosis induction pathway was constructed to explore the dominant factors of unknown criteria of cell fate decision.
Externí odkaz:
https://doaj.org/article/b1c13f2ee7db490ab0350554241e81c2
Autor:
Hiroyuki Hamada, Yoshihiko Tashima, Yu Kisaka, Kazunari Iwamoto, Taizo Hanai, Yukihiro Eguchi, Masahiro Okamoto
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4795 (2009)
The tumor suppressor, p53, regulates several gene expressions that are related to the DNA repair protein, cell cycle arrest and apoptosis induction, which activates the implementation of both cell cycle arrest and induction of apoptosis. However, it
Externí odkaz:
https://doaj.org/article/bd086858986b4a93869100f31e76b01f
Publikováno v:
Chem-Bio Informatics Journal. 16:13-24
Publikováno v:
Biosystems. 103:384-391
After DNA damage, cells activate p53, a tumor suppressor gene, and select a cell fate (e.g., DNA repair, cell cycle arrest, or apoptosis). Recently, a p53 oscillatory behavior was observed following DNA damage. However, the relationship between this
Publikováno v:
Biosystems. 94:109-117
The cell cycle has checkpoint systems, which control G1/S, G2/M and G0/G1 phase transitions. When a normal cell suffers from DNA-damage, the signal transduction of DNA-damage causes the cell cycle arrest by using the checkpoint systems. Therefore, th
Autor:
Yukihiro Eguchi
Publikováno v:
Folia Pharmacologica Japonica. 125:365-371
Autor:
Yoshiyuki Sakaki, Yukihiro Eguchi, Shigeru Muta, Yuzuru Ito, Yoriko Takahashi, Sachiyo Aburatani, Miki Ogawa, Shouji Watanabe, Kaori Hayashi, Momoka Masaki, Kiyoshi Yamamoto, Satoru Kuhara, Christopher J. Savoie, Akiko Enomoto, Kosuke Tashiro, Yukihiro Maki, Mayumi Nishizawa
Publikováno v:
DNA Research. 10:1-8
Gene regulatory networks elucidated from strategic, genome-wide experimental data can aid in the discovery of novel gene function information and expression regulation events from observation of transcriptional regulation among genes of known and unk
Autor:
Yukihiro Eguchi, Kouji Tanaka, Yukihiro Maki, Jun Ichi Ueno, Noriaki Kinoshita, Yuichi Miura, Masahiro Okamoto, Daisuke Tominaga, Yoshimitsu Morita
Publikováno v:
Computers & Chemical Engineering. 21:S745-S750
BEST-KIT is an efficient and user-friendly “biochemical engineering system analyzing tool-kit” integrated the following key modules: 1) mathematical modeling and editing of reaction-scheme, 2) automatic derivation of differential equations, 3) nu
Autor:
Yukihiro Eguchi, Taizo Hanai, Kazunari Iwamoto, Masahiro Okamoto, Yu kisaka, Hiroyuki Hamada, Yoshihiko Tashima
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4795 (2009)
PLoS ONE
PLoS ONE
The tumor suppressor, p53, regulates several gene expressions that are related to the DNA repair protein, cell cycle arrest and apoptosis induction, which activates the implementation of both cell cycle arrest and induction of apoptosis. However, it
Mathematical modeling of G2/M phase in the cell cycle with involving the p53/Mdm2 oscillation system
Autor:
Yukihiro Eguchi, Yoshihiko Tashima, Masahiro Okamoto, Hiroyuki Hamada, Yu kisaka, Taizo Hanai
Publikováno v:
World Congress on Medical Physics and Biomedical Engineering 2006 ISBN: 9783540368397
In the cell cycle, the disruption of a checkpoint control mechanism for G2/M phase which monitors DNA damages is one of the triggers for oncogenic transformation. The major event of this mechanism is the p53/Mdm2 signaling pathway-mediated repression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66052b98267c93d63f371a04ac6ecce
https://doi.org/10.1007/978-3-540-36841-0_58
https://doi.org/10.1007/978-3-540-36841-0_58