Zobrazeno 1 - 10
of 438
pro vyhledávání: '"Yukihiro, Yoshida"'
Autor:
Ken Asada, Syuzo Kaneko, Ken Takasawa, Kouya Shiraishi, Norio Shinkai, Yoko Shimada, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Amina Bolatkan, Masaaki Komatsu, Masayoshi Yamada, Mototaka Miyake, Hirokazu Watanabe, Akiko Tateishi, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background The cancer genome contains several driver mutations. However, in some cases, no known drivers have been identified; these remaining areas of unmet needs, leading to limited progress in cancer therapy. Whole-genome sequencing (WGS)
Externí odkaz:
https://doaj.org/article/5ca317bc30aa4ff796701baac2c9a5a6
Autor:
Syuzo Kaneko, Ken Takasawa, Ken Asada, Kouya Shiraishi, Noriko Ikawa, Hidenori Machino, Norio Shinkai, Maiko Matsuda, Mari Masuda, Shungo Adachi, Satoshi Takahashi, Kazuma Kobayashi, Nobuji Kouno, Amina Bolatkan, Masaaki Komatsu, Masayoshi Yamada, Mototaka Miyake, Hirokazu Watanabe, Akiko Tateishi, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Vassiliki Saloura, Takashi Kohno, Ryuji Hamamoto
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have been recognized as potential targets for molecular therapy. However, there remain cases where target genes are not identified. Super-enhancers
Externí odkaz:
https://doaj.org/article/41d2bbf4f86f4d019c77904a80b740d3
Autor:
Kaito Yano, MD, Masaya Yotsukura, MD, Hirokazu Watanabe, MD, Takaki Akamine, MD, Yukihiro Yoshida, MD, Kazuo Nakagawa, MD, Yasushi Yatabe, MD, Masahiko Kusumoto, MD, Shun-ichi Watanabe, MD
Publikováno v:
JTCVS Open, Vol 18, Iss , Pp 261-275 (2024)
Objective: Oncological feasibility of segmentectomy for internal non–small cell lung cancer (NSCLC) has not been assessed adequately. We assessed the oncological feasibility of segmentectomy for inner-located NSCLC by investigating surgical margins
Externí odkaz:
https://doaj.org/article/ca99c4a01f31448e8183f371b6c6db15
Autor:
Ken Takasawa, Ken Asada, Syuzo Kaneko, Kouya Shiraishi, Hidenori Machino, Satoshi Takahashi, Norio Shinkai, Nobuji Kouno, Kazuma Kobayashi, Masaaki Komatsu, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 3, Pp 646-655 (2024)
Abstract DNA methylation is an epigenetic modification that results in dynamic changes during ontogenesis and cell differentiation. DNA methylation patterns regulate gene expression and have been widely researched. While tools for DNA methylation ana
Externí odkaz:
https://doaj.org/article/0a8c89ddfeac4cf8b4c8994da7107c71
Autor:
Kana Ohashi, Yukari Nishito, Hironori Fukuda, Ryoichi Sadahiro, Yukihiro Yoshida, Shun-ichi Watanabe, Noriko Motoi, Yukiko Sonobe, Hideaki Mizuno, Hiroyuki Tsunoda, Koichiro Tatsumi, Takuji Suzuki, Atsushi Ochiai, Kazunori Aoki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Inflammatory factors in the peripheral blood, such as the C-reactive protein level and neutrophil-to-lymphocyte ratio (NLR), are prognostic markers in multiple types of cancer, including non-small cell lung cancer (NSCLC). However, the assoc
Externí odkaz:
https://doaj.org/article/4096f7b13c4641aa876bf2b5a00a8b84
Autor:
Taichi Igarashi, Marianne Mazevet, Takaaki Yasuhara, Kimiyoshi Yano, Akifumi Mochizuki, Makoto Nishino, Tatsuya Yoshida, Yukihiro Yoshida, Nobuhiko Takamatsu, Akihide Yoshimi, Kouya Shiraishi, Hidehito Horinouchi, Takashi Kohno, Ryuji Hamamoto, Jun Adachi, Lee Zou, Bunsyo Shiotani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Activation of the KRAS oncogene is a source of replication stress, but how this stress is generated and how it is tolerated by cancer cells remain poorly understood. Here we show that induction of KRASG12V expression in untransformed cells t
Externí odkaz:
https://doaj.org/article/43f90e5e10dd446096f58be5f96dcc74
Autor:
Akira Hamada, MD, PhD, Kazuhiro Kitajima, MD, PhD, Kenichi Suda, MD, PhD, Takamasa Koga, MD, PhD, Junichi Soh, MD, PhD, Hayato Kaida, MD, PhD, Kimiteru Ito, MD, PhD, Tetsuro Sekine, MD, PhD, Kyoshiro Takegahara, MD, PhD, Hiromitsu Daisaki, PhD, Masaki Hashimoto, MD, PhD, Yukihiro Yoshida, MD, PhD, Takanobu Kabasawa, MD, PhD, Takashi Yamasaki, MD, Seiichi Hirota, MD, PhD, Jitsuo Usuda, MD, PhD, Kazunari Ishii, MD, PhD, Tetsuya Mitsudomi, MD, PhD
Publikováno v:
JTCVS Open, Vol 14, Iss , Pp 502-522 (2023)
Objectives: Despite the prognostic impacts of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography examination, fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography–based prognosis
Externí odkaz:
https://doaj.org/article/e19c0aed51314bcc89b498ce4c184a36
Autor:
Yukihiro Yoshida, MD, Nozomu Saeki, Mphil, Masaya Yotsukura, MD, Kazuo Nakagawa, MD, Hirokazu Watanabe, MD, Yasushi Yatabe, MD, Shun-ichi Watanabe, MD
Publikováno v:
JTCVS Open, Vol 12, Iss , Pp 410-425 (2022)
Objective: We aimed to visualize complicated patterns of lymph node metastases in surgically resected non–small cell lung cancer by applying a data mining technique. Methods: In this retrospective study, 783 patients underwent lobectomy or pneumone
Externí odkaz:
https://doaj.org/article/f5f3756166f443c8a05ea1c2f12ca5d1
Autor:
Yoshinao Oda, Kazuhiro Tanaka, Takanori Hirose, Tadashi Hasegawa, Nobuyuki Hiruta, Masanori Hisaoka, Masato Yoshimoto, Hiroshi Otsuka, Hirofumi Bekki, Takeaki Ishii, Makoto Endo, Toshiyuki Kunisada, Toru Hiruma, Hiroyuki Tsuchiya, Hirohisa Katagiri, Yoshihiro Matsumoto, Akira Kawai, Robert Nakayama, Hiroyuki Kawashima, Satoshi Takenaka, Makoto Emori, Munenori Watanuki, Yukihiro Yoshida, Takeshi Okamoto, Junki Mizusawa, Haruhiko Fukuda, Toshifumi Ozaki, Yukihide Iwamoto, Takayuki Nojima
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Preoperative chemotherapy is widely applied to high-grade localized soft tissue sarcomas (STSs); however, the prognostic significance of histological response to chemotherapy remains controversial. This study aimed to standardize
Externí odkaz:
https://doaj.org/article/f883ac7597a54050a846995537069a8b
Autor:
Ken Takazawa, Jun-ichi Inoue, Kazutaka Mitsuishi, Yukihiro Yoshida, Hideo Kishida, Paul Tinnemans, Hans Engelkamp, Peter C. M. Christianen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract For decades, it has been reported that some organic crystals suddenly crack, break, or jump when they are heated from room temperature. Recently, such crystals have been intensively studied both in fundamental science and for high-speed mech
Externí odkaz:
https://doaj.org/article/f0f891379c0445828c13cb14ae1644e5