Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yukihiko Aikawa"'
Autor:
Shunichi Shiozawa, Makiko Nogami, Yukihiko Aikawa, Tomoatsu Kimura, Hiraku Motomura, Shoji Seki
Publikováno v:
Biochemical and biophysical research communications. 497(2)
The objective of the present study is to demonstrate that a newly developed selective c-Fos/activator protein (AP)-1 inhibitor, T-5224, inhibits the expression of matrix metalloproteinases (MMPs) in human articular chondrocytes, and prevents cartilag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deba55742afab461aa57949afc8254e1
https://pubmed.ncbi.nlm.nih.gov/29476740
https://pubmed.ncbi.nlm.nih.gov/29476740
Autor:
Kenta Watanabe, Hiroto Makino, Shunichi Shiozawa, Mitsuaki Yamazaki, Yoshiharu Kawaguchi, Tomoatsu Kimura, Hiraku Motomura, Noriyuki Tsumaki, Shoji Seki, Takeshi Sainoh, Yukihiko Aikawa, Yasuhito Yahara, Hisakatsu Ito, Makiko Nogami
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Intervertebral disc (IVD) degeneration is a major cause of low back pain. The transcription factor c-Fos/Activator Protein-1 (AP-1) controls the expression of inflammatory cytokines and matrix metalloproteinases (MMPs) that contribute to the pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c6c6a5525f8dfb397fd75c68c168bf
http://hdl.handle.net/2433/235520
http://hdl.handle.net/2433/235520
Autor:
Tetsuya Yamamoto, Kimiko Morimoto, Hisaaki Chaki, Shuichi Hirono, Akira Hashiramoto, Hirokazu Narita, Yukihiko Aikawa, Shunichi Shiozawa
Publikováno v:
Nature Biotechnology. 26:817-823
To inhibit arthritis upstream of inflammatory cytokine release and matrix metalloproteinase (MMP) action, we designed de novo a small-molecule inhibitor of c-Fos/activator protein-1 (AP-1) using three-dimensional (3D) pharmacophore modeling. This mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7feb853cafe48ebec6136235f15b473
https://doi.org/10.1038/nbt1412
https://doi.org/10.1038/nbt1412
Autor:
Yukihiko Aikawa, Tadakazu Takakura, Keiichi Tsuchida, Shuichi Hirono, Hisaaki Chaki, Hiroaki Gouda, Shunichi Shiozawa, Junichi Yokotani
Publikováno v:
Journal of Medicinal Chemistry. 47:4239-4246
The transcription factor activator protein-1 (AP-1) is an attractive target for the treatment of immunoinflammatory diseases, such as rheumatoid arthritis. Using the three-dimensional (3D) X-ray crystallographic structure of the DNA-bound basic regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9177f136e8a0c6d40b6a681a50afce
https://doi.org/10.1021/jm049890+
https://doi.org/10.1021/jm049890+
Autor:
Yoh Matsumoto, Kuniko Kohyama, Yoko Kawazoe, Yukihiko Aikawa, Yoko Suzuki, Naoyuki Tanuma, Taekyun Shin
Publikováno v:
European Journal of Immunology. 28:1681-1688
To elucidate the role of NK cells and TCR gamma delta+ T cells in acute experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats, the distribution, number and function of these cells were studied using several methods. Immunohistochemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e2ce38d8e7b49177e984f7c4eefae7
https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1681::aid-immu1681>3.0.co
https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1681::aid-immu1681>3.0.co
Publikováno v:
Journal of the Neurological Sciences. 151:141-148
Experimental autoimmune myositis (EAM) was induced in Lewis rats by immunization with partially purified and purified skeletal myosin. Although clinical signs such as muscle weakness were very mild, multiple inflammatory lesions in the skeletal muscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c346991d25f45b0afeef7119ea3a4391
https://doi.org/10.1016/s0022-510x(97)00148-2
https://doi.org/10.1016/s0022-510x(97)00148-2
Autor:
Toshihiko Kohji, Takashi Kojima, Yukihiko Aikawa, Taekyun Shin, Naoyuki Tanuma, Yoshihiro Ishihara, Yoh Matsumoto
Publikováno v:
Journal of Neuroimmunology. 73:197-206
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the central nervous system that can be induced by immunization with myelin basic protein (MBP)/complete Freund's adjuvant and serves as a model for multiple sclerosis. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eafbe728640fe2a352e2a01467c02d
https://doi.org/10.1016/s0165-5728(96)00199-3
https://doi.org/10.1016/s0165-5728(96)00199-3
Autor:
Kiyonobu Kurata, Takihiro Inaba, Yukihiko Aikawa, Hiroki Kawasaki, Keiichi Tanaka, Yoko Tsukamoto
Publikováno v:
Japanese Journal of Pharmacology. 67:305-314
To elucidate the mechanism for the selective inhibition of prostaglandin E2 (PGE2) production in inflammatory tissue by T-614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne), its effects on both the activity and the induction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6b7ce1b11785f0cc47f8a9cae35f57
https://doi.org/10.1254/jjp.67.305
https://doi.org/10.1254/jjp.67.305
Autor:
Takihiro Inaba, Yukihiko Aikawa, Keiichi Tanaka, Keiko Asaoka, Chosaku Yoshida, Hiroki Kawasaki
Publikováno v:
Journal of Pharmacobio-Dynamics. 15:649-655
In vitro effects of 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-on e (T-614), a novel antiinflammatory compound, on the production of interleukin-1 (IL-1) and/or interleukin-6 (IL-6) by human monocytes and the THP-1 cells of a hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04bcceca06d9c7e0d30c564d2082bd0
https://doi.org/10.1248/bpb1978.15.649
https://doi.org/10.1248/bpb1978.15.649
Autor:
Tadakazu Takakura, Hisaaki Chaki, Hironori Kotsubo, Shunichi Shiozawa, Tadashi Tanaka, Yukihiko Aikawa, Shuichi Hirono, Keiichi Tsuchida
Publikováno v:
Journal of medicinal chemistry. 49(1)
We designed and synthesized small-molecule activator protein-1 (AP-1) inhibitors based on a three-dimensional (3D) pharmacophore model that we had previously derived from a cyclic decapeptide exhibiting AP-1 inhibitory activity. New AP-1 inhibitors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6935b55cb5b0c1b86acf56fd080b3752
https://pubmed.ncbi.nlm.nih.gov/16392794
https://pubmed.ncbi.nlm.nih.gov/16392794