Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yukiharu Nakayama"'
Autor:
Etsuko Satoh, Atsushi Miyachi, Yukiharu Nakayama, Noriaki Katoh, Takashi Nakamura, Katsuto Abe, Takayo Murase, Naoyuki Ogawa
Publikováno v:
Integrative Molecular Medicine. 6
Autor:
Noriaki Katoh, Etsuko Satoh, Chihiro Hibi, Hirofumi Tomita, Yukiharu Nakayama, Takayo Murase, Hiroaki Yokoyama, Takashi Nakamura
Publikováno v:
Journal of Molecular Biomarkers & Diagnosis.
Publikováno v:
International Journal of Pharmaceutics. 336:99-107
Pellet formulations as represented by multiparticulate systems are often contained in hard capsules. We examined the use of a different approach to the making of compressed tablets containing pellets, OSDRC-technology. OSDRC-technology employs a doub
Publikováno v:
Journal of Neurochemistry. 91:1430-1438
Development of hypesthesia, a loss of sensitivity to stimulation, is associated with impaired regeneration of peripheral sensory fibers, in which Schwann cells play a key role by secreting nerve growth factor (NGF). Recent clinical trials indicated t
Autor:
Kaoru Takanaka, Yukiharu Nakayama, Keiichi Ida, Shunichi Kametani, Toshio Inoda, Takashi Izumi, Masato Tani, Kouichi Nakamura, Eiji Kashiyama, Shigemichi Morita, Fukuichi Ohsawa, Shuichi Sakai, Meguru Achira, Akira Kagayama, Satoru Asahi, Nobuo Osawa, Jun Morita, Yoshinobu Yoshimura, Kimitoshi Saito, Yoshiaki Terauchi, Takuro Niwa, Osamu Takenaka, Takanori Hashizume, Kiyoshi Noguchi, Toshifumi Shiraga, Yasuhiro Nakai, Satoshi Omori, Akinori Aoyama, Takashi Kuwabara, Hiroyuki Kawai, Akio Nakamura, Toshiyuki Kume, Sekio Nagayama, Masahiko Iwasaki, Takuya Yoshimura, Mitsuaki Takeuchi, Hideki Nakamura, Takashi Kawashiro, Takeshi Nakabayashi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 19:444-452
As a part of the studies conducted by the Pharma SNPs Consortium (PSC), the enzyme activities of CYP1A2, CYP2A6 and CYP2B6 variants with altered amino acids as a result of single nucleotide polymorphisms (SNPs) found among the Japanese population wer
Publikováno v:
Journal of Diabetes and its Complications. 17:374-379
It is important to suppress retinal vascular changes for prevention of the onset and progression of diabetic retinopathy. In the present study, we investigated the dose-response effect of an aldose reductase (AR) inhibitor, fidarestat, on retinal vas
Publikováno v:
Biological and Pharmaceutical Bulletin. 25:1063-1071
The effects of SK-896, a new human motilin analogue ([Leu13]motilin-Hse), on digestive tract motility in postoperative ileus were evaluated in a dog model of ileus after laparotomy. SK-896 was intravenously administered at 0.17, 0.33 and 0.67 microg/
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:528-536
In this study, the feto-placental transfer or excretion into the milk of SK-896 ([Leu13]motilin-Hse), a new human motilin analogue, were assessed after single intravenous injection of gestation or lactating female rats with 3H-SK-896. Two min after i
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:436-444
In this study, the distribution and accumulation of SK-896 ([Leu13]motilin-Hse), a new human motilin analogue, were assessed after single or repeated intravenous administration of rats with3H-SK-896. Following intravenous bolus injection of male rats
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:445-450
SK-896 ([Leu13]motilin-Hse) is a new human motilin analogue synthesized by Escherichia coli using a biotechnological method. In this study, the pharmacokinetic properties of SK-896 after a single intravenous injection or during and after a single con