Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yukie Shigemoto"'
Autor:
Hiroshi, Komura, Yukie, Shigemoto, Iichiro, Kawahara, Kenichi, Matsuda, Rieko, Ano, Yoko, Murayama, Toshiya, Moriwaki, Nagahiro H, Yoshida
Publikováno v:
YAKUGAKU ZASSHI. 125:141-147
Pharmacokinetic and metabolic screening plays an important role in the optimization of a lead compound in drug discovery. Since those screening methods are time-consuming and labor intensive, in silico models would be effective to select compounds an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b974cf7019413e7d1e9feba13b76ff
https://doi.org/10.1248/yakushi.125.141
https://doi.org/10.1248/yakushi.125.141
Autor:
Hiroshi Komura, Toshiya Moriwaki, Rieko Ano, Yoko Murayama, Iichiro Kawahara, Yukie Shigemoto, Nagahiro Yoshida, Kenichi Matsuda
Publikováno v:
YAKUGAKU ZASSHI. 125:131-139
Metabolic screening using liver microsomes of rats and humans is an indispensable tool to optimize a lead structure and to select compounds for in vivo study. Elucidating the relationship between in vitro intrinsic clearance (CL(int, app)) and in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312e1315b40dfe188a11569db6769241
https://doi.org/10.1248/yakushi.125.131
https://doi.org/10.1248/yakushi.125.131
Publikováno v:
Journal of Pharmaceutical Sciences. 91:196-205
A recirculatory model for the portal–systemic blood concentration difference (P–S difference) was developed to separately evaluate the rate and extent of absorption from the gastrointestinal tract into the portal system and disposition of a drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd7bc7ac0e1dc4843c5bc517c000a61
https://doi.org/10.1002/jps.10016
https://doi.org/10.1002/jps.10016
Autor:
Hiroshi, Komura, Kenichi, Matsuda, Yukie, Shigemoto, Iichiro, Kawahara, Rieko, Ano, Yoko, Murayama, Toshiya, Moriwaki, Nagahiro H, Yoshida
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 125(1)
Metabolic screening using liver microsomes of rats and humans is an indispensable tool to optimize a lead structure and to select compounds for in vivo study. Elucidating the relationship between in vitro intrinsic clearance (CL(int, app)) and in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de722013259c9f5a26b8077ca4b46fd9
https://pubmed.ncbi.nlm.nih.gov/15635284
https://pubmed.ncbi.nlm.nih.gov/15635284