Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Yukie Saegusa"'
Autor:
Kota Nakajima, Ayumi Eguchi, Toshinori Yoshida, Nobuhiko Onda, Rei Nagahara, Yukie Saegusa, Makoto Shibutani, Mari Inohana, Misato Nakamura
Publikováno v:
Toxicological Sciences
Aluminum (Al) is neurotoxic to adults and also to infants. In this study, we investigated the developmental exposure effect of AlCl3 on postnatal hippocampal neurogenesis. Pregnant mice were administered 0-, 900-, or 1800-ppm AlCl3 via drinking water
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d11c6b4147572edc149272a0abfcee8
https://doi.org/10.1093/toxsci/kfy081
https://doi.org/10.1093/toxsci/kfy081
Autor:
Yuko Ito, Kota Nakajima, Mari Inohana, Masahiko Takino, Yoshiko Sugita-Konishi, Yasunori Masubuchi, Toshinori Yoshida, Yukie Saegusa, Makoto Shibutani
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 120
To investigate the developmental exposure effect of citreoviridin (CIT) on postnatal hippocampal neurogenesis, pregnant ICR mice were dietary exposed to CIT at 0, 1, 3 and 10 ppm from gestation day 6 to postnatal day (PND) 21 on weaning. Offspring we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931bd18746c38edcb2c30d0dfc3186af
https://pubmed.ncbi.nlm.nih.gov/30071239
https://pubmed.ncbi.nlm.nih.gov/30071239
Autor:
Toshinori Yoshida, Sayaka Mizukami, Yousuke Watanabe, Yukie Saegusa, Makoto Shibutani, Yasunori Masubuchi, Kota Nakajima, Yuko Ito
Publikováno v:
Toxicology and applied pharmacology. 334
We previously found downregulation of ubiquitin-conjugating enzyme E2E 2 (UBE2E2) in GST-P-positive (+) proliferative lesions produced by tumor promotion from early hepatocarcinogenesis stages in rats. Here we investigated the role of UBE2E2 downregu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1189371651255c81b4f97bf24e5073
https://pubmed.ncbi.nlm.nih.gov/28899750
https://pubmed.ncbi.nlm.nih.gov/28899750
Autor:
Kumiko Ogawa, Kouhei Amakasu, Takuya Nishimura, Yukie Saegusa, Misaki Naota, Akiyoshi Nishikawa, Mizuho Nonaka
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 86
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) has been conducting a prospective evaluation period to validate the criteria for waiving some carcinogenicity studies in rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cabb50dc843b93948478713a5266a61
https://pubmed.ncbi.nlm.nih.gov/28288808
https://pubmed.ncbi.nlm.nih.gov/28288808
Autor:
Takumi Ohishi, Makoto Shibutani, Liyun Wang, Gye-Hyeong Woo, Akiyoshi Nishikawa, Yukie Saegusa, Kunitoshi Mitsumori, Hitoshi Fujimoto
Publikováno v:
Archives of Toxicology. 86:1431-1442
We immunohistochemically investigated the impact and reversibility of three brominated flame retardants (BFRs) known to be weak thyroid hormone disruptors on neuronal development in the hippocampal formation and apoptosis in the dentate subgranular z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b82b9ccc8e0a6f0060715e01486e61a
https://doi.org/10.1007/s00204-012-0824-4
https://doi.org/10.1007/s00204-012-0824-4
Autor:
Jihei Nishimura, Masaomi Kawai, Sayaka Kenmochi, Makoto Shibutani, Yukie Saegusa, Tomoaki Harada, Kunitoshi Mitsumori, Yasuaki Dewa, Meilan Jin, Keisuke Shimamoto
Publikováno v:
Archives of Toxicology. 85:155-162
The present study was performed to characterize immunohistochemically the expression levels of molecules related to not only xenobiotic and antioxidant functions but also cell proliferation and apoptosis in neoplastic lesions induced by the benzimida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb37d00502508a4fe1787910c37683a5
https://doi.org/10.1007/s00204-010-0557-1
https://doi.org/10.1007/s00204-010-0557-1
Autor:
Masaomi Kawai, Makoto Shibutani, Tomoaki Harada, Kunitoshi Mitsumori, Sayaka Kemmochi, Keisuke Shimamoto, Yukie Saegusa
Publikováno v:
Journal of Veterinary Medical Science. 72:263-269
In order to clarify whether cytokeratin (CK) 8/18 is a useful immunohistochemical marker for hepatocellular proliferative lesions in mice, partially hepatectomized male ICR mice were given 0.6% piperonyl butoxide (PBO) for 8 (Experiment I) or 25 week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ae107b25a318f6be247c49d5bb1d0d
https://doi.org/10.1292/jvms.09-0329
https://doi.org/10.1292/jvms.09-0329
Autor:
Sayaka Kemmochi, Yukie Saegusa, Meilan Jin, Makoto Shibutani, Yasuaki Dewa, Masaomi Kawai, Tomoaki Harada, Kunitoshi Mitsumori, Jihei Nishimura
Publikováno v:
The Journal of Toxicological Sciences. 35:69-78
To determine the threshold dose of dicyclanil (DC) that induces hepatocellular tumor-promoting effects associated with reactive oxygen species (ROS) generation via their metabolic pathways, partial hepatectomized ICR male mice were fed diets containi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b008d2c15438a1816c950b500ff22cd2
https://doi.org/10.2131/jts.35.69
https://doi.org/10.2131/jts.35.69
Autor:
Akiyoshi Nishikawa, Masao Hirose, Makoto Shibutani, Gye-Hyeong Woo, Miwa Takahashi, Hitoshi Fujimoto, Yukie Saegusa, Kaoru Inoue
Publikováno v:
Reproductive Toxicology. 28:297-307
To clarify the developmental effects of hypothyroidism and to establish a detection system of resultant brain retardation, pregnant rats were administered 3 or 12 ppm of 6-propyl-2-thiouracil (PTU) or 200 ppm of methimazole (MMI) in the drinking wate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058483e24089b69433c8387052ebdc8d
https://doi.org/10.1016/j.reprotox.2009.04.011
https://doi.org/10.1016/j.reprotox.2009.04.011
Autor:
Masaomi Kawai, Yasuaki Dewa, Tomoaki Harada, Yukie Saegusa, Kunitoshi Mitsumori, Jihei Nishimura, Meilan Jin, Makoto Shibutani
Publikováno v:
Toxicologic Pathology. 37:446-455
The present study was performed to characterize molecular expression levels of preneoplastic and neoplastic lesions induced by β-naphthoflavone (BNF), an aryl hydrocarbon receptor (AhR) agonist in rat hepatocarcinogenesis. Male F344 rats were initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcaa50d89c4031fe5d4e4901d7a5092e
https://doi.org/10.1177/0192623309335062
https://doi.org/10.1177/0192623309335062