Výsledky vyhledávání - "Yukie Kushimura"

Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs

Autor: Takahiko Tokuda, Luca Lo Piccolo, Yukie Kushimura, Kojiro Suda, Masanori Nakagawa, Yumiko Azuma, Aya Nakamura, Ikuko Mizuta, Masamitsu Yamaguchi, Toshiki Mizuno, Ryo Tanaka, Yuuka Muraoka, Hideki Yoshida

Publikováno v: Experimental Neurology. 310:1-13

Neuron-specific knockdown of the dFIG4 gene, a Drosophila homologue of human FIG4 and one of the causative genes for Charcot-Marie-Tooth disease (CMT), reduces the locomotive abilities of adult flies, as well as causing defects at neuromuscular junct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2ec5d035262ba58e03469aa3db40fa
https://doi.org/10.1016/j.expneurol.2018.08.009

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Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS

Autor: Takahiko Tokuda, Yumiko Azuma, Mari Yoshida, Yasushi Iwasaki, Masanori Nakagawa, Ikuko Mizuta, Yoshitaka Nagai, Toshiki Mizuno, Morio Ueyama, Yukie Kushimura, Masamitsu Yamaguchi, Duojia Pan, Hideki Yoshida, Itaru Yamamoto

Publikováno v: Experimental Cell Research. 371:311-321

Mutations in the Fused in Sarcoma (FUS) gene have been identified in familial ALS in human. Drosophila contains a single ortholog of human FUS called Cabeza (Caz). We previously established Drosophila models of ALS targeted to Caz, which developed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5613841ba0d20935418e8020c72a52a3
https://doi.org/10.1016/j.yexcr.2018.08.001

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Loss-of-function mutation in Hippo suppressed enlargement of lysosomes and neurodegeneration caused by dFIG4 knockdown

Autor: Yukie Kushimura, Yumiko Azuma, Takahiko Tokuda, Yuuka Muraoka, Akane Kyotani, Masamitsu Yamaguchi, Toshiki Mizuno, Hideki Yoshida, Ikuko Mizuta

Publikováno v: NeuroReport. 29:856-862

Charcot-Marie-Tooth disease (CMT) is the most common hereditary neuropathy, and more than 80 CMT-causing genes have been identified to date. CMT4J is caused by a loss-of-function mutation in the Factor-Induced-Gene 4 (FIG4) gene, the product of which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c130c98625a3a7c8e4b70afc6efa73
https://doi.org/10.1097/wnr.0000000000001044

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An Adult Case of Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-associated Multiphasic Acute Disseminated Encephalomyelitis at 33-year Intervals

Autor: Masanori Nakagawa, Ayaka Kimura, Takayuki Kondo, Soichiro Numa, Takashi Kasai, Tomoyuki Ohara, Yukie Kushimura, Toshiki Mizuno, Akihiro Tanaka, Kanako Morita, Hisashi Takahashi, Yu-ichi Noto

Publikováno v: Internal Medicine. 55:699-702

Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2401c608b5e611a064d698d7c79a67
https://doi.org/10.2169/internalmedicine.55.5727

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NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene

Autor: Itaru Yamamoto, Toshiki Mizuno, Takahiko Tokuda, Ikuko Mizuta, Yukie Kushimura, Hideki Yoshida, Yoshitaka Nagai, Morio Ueyama, Yumiko Azuma, Masamitsu Yamaguchi

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)

Fused in sarcoma (FUS) was identified as a component of typical inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In FTLD, both nuclear and cytoplasmic inclusions with wild-type FUS exist, while cytoplasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82207bb9d3744a8cbeb0ccfe0867f00
https://pubmed.ncbi.nlm.nih.gov/30050143

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Head drop syndrome in a patient with immune-mediated necrotizing myopathy with anti-signal recognition particle antibody: a case report

Autor: Yukie, Kushimura, Kensuke, Shiga, Mao, Mukai, Masakatu, Yoshida, Toshiki, Mizuno, Masanori, Nakagawa

Publikováno v: Rinsho Shinkeigaku. 53:41-45

We report an 87-year-old female patient who presented a dropped head and progressive weakness in proximal muscles over five months. The value of serum creatine kinase was 2,708 IU/l and the antibody against signal recognition particle (SRP) was detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f13ca711000e65cc6524aa1a1c5646
https://doi.org/10.5692/clinicalneurol.53.41

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Myasthenic symptoms in anti-low-density lipoprotein receptor-related protein 4 antibody-seropositive amyotrophic lateral sclerosis: two case reports

Autor: Ryotaro Ishii, Toshiki Mizuno, Yu Ichi Noto, Shunya Nakane, Tomoyuki Ohara, Masanori Nakagawa, Yukie Kushimura-Okada, Naoki Makita, Akihiro Tanaka, Hisashi Takahashi, Osamu Higuchi

Publikováno v: BMC Neurology

Background Myasthenic symptoms can be present in patients with amyotrophic lateral sclerosis (ALS). These symptoms have been considered to be caused by the degeneration of distal motor neurons and the neuromuscular junction (NMJ). Recent studies sugg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b921319f9ac86baf7e669d096f501a78
https://pubmed.ncbi.nlm.nih.gov/27863479

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