Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Yukie, Yoshii"'
Autor:
Mitsuhiro Shinada, Masashi Takahashi, Chika Igarashi, Hiroki Matsumoto, Fukiko Hihara, Tomoko Tachibana, Masakazu Oikawa, Hisashi Suzuki, Ming-Rong Zhang, Tatsuya Higashi, Hiroaki Kurihara, Yukie Yoshii, Yoshihiro Doi
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 820 (2024)
Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. 64Cu2+ is an anticancer radiopharmaceutical that targets the copper requirement of cancer cells. However, intravenously injected 64Cu2+ ions
Externí odkaz:
https://doaj.org/article/2ec27f9bcaab4665b5ade683d11324ac
Autor:
Mitsuhiro Shinada, Hisashi Suzuki, Masayuki Hanyu, Chika Igarashi, Hiroki Matsumoto, Masashi Takahashi, Fukiko Hihara, Tomoko Tachibana, Chizuru Sogawa, Ming-Rong Zhang, Tatsuya Higashi, Hidemitsu Sato, Hiroaki Kurihara, Yukie Yoshii, Yoshihiro Doi
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 10 (2023)
[64Cu]Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM) is a radioactive hypoxia-targeting therapeutic agent being investigated in clinical trials for malignant brain tumors. For the quality management of [64Cu]Cu-ATSM, understanding trace
Externí odkaz:
https://doaj.org/article/c8bb42d4b1ee4732af26836bf81048f1
Autor:
Yukie Yoshii, Hiroki Matsumoto, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Mitsuhiro Shinada, Atsuo Waki, Sei Yoshida, Kenichiro Naito, Kimiteru Ito, Tatsuya Higashi, Hiroaki Kurihara, Makoto Ueno
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1341 (2023)
Understanding the physicochemical properties of antibody–drug conjugates is critical to assess their quality at manufacturing and monitor them during subsequent storage. For radiometal–antibody complexes, it is important to control the properties
Externí odkaz:
https://doaj.org/article/7b2fb5433caf4e8faa8f63f71d8cb5a2
Autor:
Hiroki Matsumoto, Yukie Yoshii, Atsumi Baden, Emi Kaneko, Hiroki Hashimoto, Hisashi Suzuki, Kazunori Kawamura, Ming-Rong Zhang, Tatsuya Higashi, Hiroaki Kurihara
Publikováno v:
Translational Oncology, Vol 12, Iss 9, Pp 1206-1212 (2019)
Hypoxia plays important roles in the prognosis of malignant brain tumors such as glioblastoma because it causes drug delivery deficiencies and the induction of hypoxia-inducible factor-1α in tumor cells. Extensive hypoxic areas are associated with p
Externí odkaz:
https://doaj.org/article/6d092e0bc1ee40ebadc129e19f156f87
Autor:
Hiroki Matsumoto, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Mitsuhiro Shinada, Atsuo Waki, Sei Yoshida, Kenichiro Naito, Hiroaki Kurihara, Makoto Ueno, Kimiteru Ito, Tatsuya Higashi, Yukie Yoshii
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1928 (2022)
Detecting tumor lesions 64Cu-labeled anti-epidermal growth factor receptor (EGFR) antibody (64Cu-NCAB001 ipPET). Here, we conducted an extended single-dose toxicity study of 64Cu-NCAB001 ipPET in mice based on approach 1 of the current ICH M3 [R2] gu
Externí odkaz:
https://doaj.org/article/e8ac0a2197c1475b8a9f438d53777509
Autor:
Zhao-Hui Jin, Atsushi B. Tsuji, Mélissa Degardin, Aya Sugyo, Yukie Yoshii, Kotaro Nagatsu, Ming-Rong Zhang, Yasuhisa Fujibayashi, Pascal Dumy, Didier Boturyn, Tatsuya Higashi
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Background The present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined the efficacy of a combination of a te
Externí odkaz:
https://doaj.org/article/8b0bf5d5939249e6adaaf9de3eb3dad2
Autor:
Yukie Yoshii, Hiroki Matsumoto, Mitsuyoshi Yoshimoto, Ming-Rong Zhang, Yoko Oe, Hiroaki Kurihara, Yoshitaka Narita, Zhao-Hui Jin, Atsushi B Tsuji, Keiichiro Yoshinaga, Yasuhisa Fujibayashi, Tatsuya Higashi
Publikováno v:
Translational Oncology, Vol 11, Iss 1, Pp 24-30 (2018)
Glioblastoma is the most aggressive malignant brain tumor in humans and is difficult to cure using current treatment options. Hypoxic regions are frequently found in glioblastoma, and increased levels of hypoxia are associated with poor clinical outc
Externí odkaz:
https://doaj.org/article/ff88f1ac1c6143eaac758d45fc8dcba3
Autor:
Hiroki Matsumoto, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Atsuo Waki, Ming-Rong Zhang, Sei Yoshida, Kenichiro Naito, Hiroaki Kurihara, Makoto Ueno, Kimiteru Ito, Tatsuya Higashi, Yukie Yoshii
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 67 (2021)
Early diagnosis of pancreatic cancer using current imaging modalities remains challenging. We have developed a new approach to identify tumor lesions ≥ 3 mm in the pancreas by positron emission tomography (PET) with a new intraperitoneally administ
Externí odkaz:
https://doaj.org/article/6a644441e22d458fbd7b4e0d9f7baf4e
Autor:
Mitsuyoshi Yoshimoto, Yukie Yoshii, Hiroki Matsumoto, Mitsuhiro Shinada, Masashi Takahashi, Chika Igarashi, Fukiko Hihara, Tomoko Tachibana, Ayano Doi, Tatsuya Higashi, Hirofumi Fujii, Kohshin Washiyama
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1706 (2021)
Actinium-225 (225Ac) is a promising radionuclide used in targeted alpha therapy (TAT). Although 225Ac labeling of bifunctional chelating ligands is effective, previous in vivo studies reported that free 225Ac can be released from the drugs and that s
Externí odkaz:
https://doaj.org/article/0469259c26574176ac2f6b94f2f08236
Autor:
Hiroki Matsumoto, Tadashi Watabe, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Atsuo Waki, Ming-Rong Zhang, Hideaki Tashima, Taiga Yamaya, Kazuhiro Ooe, Eku Shimosegawa, Jun Hatazawa, Sei Yoshida, Kenichiro Naito, Hiroaki Kurihara, Makoto Ueno, Kimiteru Ito, Tatsuya Higashi, Yukie Yoshii
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 950 (2021)
Objectives: To improve the prognosis of pancreatic cancer, new imaging methods to identify tumor lesions at a size of 64Cu-labeled new anti-epidermal growth factor receptor (EGFR) antibody (encoded as NCAB001), called 64Cu-NCAB001 ipPET. Methods: NCA
Externí odkaz:
https://doaj.org/article/03f327a0c083423c9b177d4f28c40246