Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Yuki Utsugi"'
Autor:
Yuki Utsugi, Yusaku Miyamae
Publikováno v:
Applied Sciences, Vol 11, Iss 18, p 8300 (2021)
Proteins are fundamental biomolecules of living cells, and their expression levels depend on the balance between the synthesis and degradation. Researchers often aim to control protein expression levels for the investigation of protein function and i
Externí odkaz:
https://doaj.org/article/fc6b6952d3944203a01d1b0cd39b4bd5
Autor:
Yuki Utsugi, Hirona Kobuchi, Yukio Kawamura, Ahmed Salahelden Aboelhamd Atito, Masaya Nagao, Hiroko Isoda, Yusaku Miyamae
Publikováno v:
Molecules, Vol 24, Iss 10, p 2019 (2019)
Covalent agonists of PPARγ cause unique receptor conformational changes and behave as selective PPARγ modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-b
Externí odkaz:
https://doaj.org/article/b7a1ac4a699440e59609e61f7ac4a471
Autor:
Yusaku Miyamae, Yuki Utsugi
Publikováno v:
Applied Sciences, Vol 11, Iss 8300, p 8300 (2021)
Proteins are fundamental biomolecules of living cells, and their expression levels depend on the balance between the synthesis and degradation. Researchers often aim to control protein expression levels for the investigation of protein function and i
Publikováno v:
Cell Chem Biol
Here, we report a method to regulate cellular protein levels by introducing a ubiquitin variant between a destabilizing domain (DD) and the regulated protein. When produced in the absence of a stabilizing ligand the DD dominates and the entire fusion