The MTR4/hnRNPK complex surveils aberrant polyadenylated RNAs with multiple exons

Autor: Kenzui Taniue, Anzu Sugawara, Chao Zeng, Han Han, Xinyue Gao, Yuki Shimoura, Atsuko Nakanishi Ozeki, Rena Onoguchi-Mizutani, Masahide Seki, Yutaka Suzuki, Michiaki Hamada, Nobuyoshi Akimitsu

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract RNA surveillance systems degrade aberrant RNAs that result from defective transcriptional termination, splicing, and polyadenylation. Defective RNAs in the nucleus are recognized by RNA-binding proteins and MTR4, and are degraded by the RNA

Externí odkaz: https://doaj.org/article/f9709f2ac81943469067156ce2a93e1d

RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival

Autor: Kenzui Taniue, Tanzina Tanu, Yuki Shimoura, Shuhei Mitsutomi, Han Han, Rika Kakisaka, Yusuke Ono, Nobue Tamamura, Kenji Takahashi, Youichiro Wada, Yusuke Mizukami, Nobuyoshi Akimitsu

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 496, p 496 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 496
International Journal of Molecular Sciences

The RNA exosome is a multi-subunit ribonuclease complex that is evolutionally conserved and the major cellular machinery for the surveillance, processing, degradation, and turnover of diverse RNAs essential for cell viability. Here we performed integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef0ad118a1defc901be31b3654ae7ed
https://www.mdpi.com/1422-0067/23/1/496