Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Yuki Maemoto"'
1
Akademický článek
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression
Autor: Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701.
Externí odkaz: https://doaj.org/article/854cca959e544001b639a7418e25c89f
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2
Akademický článek
DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes
Autor: Yuki Maemoto, Tomohiro Maruyama, Kazuaki Nemoto, Takashi Baba, Manae Motohashi, Akihiro Ito, Mitsuo Tagaya, Katsuko Tani
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth. Depletion of DDHD1 from
Externí odkaz: https://doaj.org/article/59ff45338bbc44e59edf7cb8a11cf37e
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3
Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP–TEAD interaction and its potential as an anticancer agent
Autor: Saaya Sekine, Shohei Takase, Runa Hayase, Kota Noritsugu, Yuki Maemoto, Yasue Ichikawa, Kenji Ogawa, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Akihiro Ito
Publikováno v: Bioscience, Biotechnology, and Biochemistry. 87:501-510
TEAD is a transcription factor responsible for the output of the tumor suppressor Hippo pathway. The transcriptional activity of TEAD requires molecular interaction with its transcriptional coactivator, YAP. Aberrant activation of TEAD is deeply invo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36cc55f3a544c5dfbf2ec4f3e2ceb89f
https://doi.org/10.1093/bbb/zbad022
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6
Data from Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes
Autor: Hironori Harada, Daniel T. Starczynowski, Shigeru Yanagi, Akihiro Ito, Yuki Maemoto, Daichi Sadato, Natsumi Matsunuma, Kwangmin Choi, Yuka Harada, Yoshihiro Hayashi, Yasushige Aoyagi
Ineffective hematopoiesis is a fundamental process leading to the pathogenesis of myelodysplastic syndromes (MDS). However, the pathobiological mediators of ineffective hematopoiesis in MDS remain unclear. Here, we demonstrated that overwhelming mito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b6911e868523d6984aa6a04b244d92
https://doi.org/10.1158/2159-8290.c.6549430.v1
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7
Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes
Autor: Yasushige Aoyagi, Shigeru Yanagi, Yoshihiro Hayashi, Daniel T. Starczynowski, Yuki Maemoto, Daichi Sadato, Hironori Harada, Natsumi Matsunuma, Akihiro Ito, Kwangmin Choi, Yuka Harada
Publikováno v: Cancer Discovery. 12:250-269
Ineffective hematopoiesis is a fundamental process leading to the pathogenesis of myelodysplastic syndromes (MDS). However, the pathobiological mediators of ineffective hematopoiesis in MDS remain unclear. Here, we demonstrated that overwhelming mito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6465c44b4692f5ae4a2eb3e7f72af3ec
https://doi.org/10.1158/2159-8290.cd-21-0032
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8
Improving reactivity of naphthalimide-based GST probe by imparting TPP cation: Development and application for live cell imaging
Autor: Yuuta Fujikawa, Kenta Terakado, Sayaka Nezu, Kota Noritsugu, Yuki Maemoto, Akihiro Ito, Hideshi Inoue
Publikováno v: Bioorganicmedicinal chemistry letters. 80
Glutathione S-transferases (GSTs) are a superfamily of multifunctional enzymes comprising multiple classes and subtypes. This paper describes the synthesis and characterization of TPPBN-1, a naphthalimide derivative conjugated with a triphenylphospho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df25839584eaefde26b5db22297b9db
https://pubmed.ncbi.nlm.nih.gov/36549395
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10
DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes
Autor: Takashi Baba, Tomohiro Maruyama, Kazuaki Nemoto, Mitsuo Tagaya, Manae Motohashi, Yuki Maemoto, Katsuko Tani, Akihiro Ito
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth. Depletion of DDHD1 from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6defc6d0d0e578328344795c44d206
https://www.frontiersin.org/article/10.3389/fcell.2020.00670/full
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