Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Yuki Kurauchi"'
Autor:
Kensuke Motomura, Erika Ueda, Alex Boateng, Masaharu Sugiura, Keiichi Kadoyama, Natsuko Hitora-Imamura, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Aromatic (Ar)-turmerone is a bioactive component of turmeric oil obtained from Curcuma longa. We recently identified a novel analog (A2) of ar-turmerone that protects dopaminergic neurons from toxic stimuli by activating nuclear factor
Externí odkaz:
https://doaj.org/article/d9db6cc762ad412d96ad6591a73bf799
Autor:
Keita Kinoshita, Kensuke Motomura, Keisuke Ushida, Yuma Hirata, Ayumu Konno, Hirokazu Hirai, Shunsuke Kotani, Natsuko Hitora-Imamura, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00370- (2024)
Hemorrhage-induced injury of the corticospinal tract (CST) in the internal capsule (IC) causes severe neurological dysfunction in both human patients and rodent models of intracerebral hemorrhage (ICH). A nuclear receptor Nurr1 (NR4A2) is known to ex
Externí odkaz:
https://doaj.org/article/5ca566014b614774ad88d7de781b319a
Autor:
Akiko Idera, Lisa M. Sharkey, Yuki Kurauchi, Keiichi Kadoyama, Henry L. Paulson, Hiroshi Katsuki, Takahiro Seki
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 3, Pp 182-192 (2023)
Missense mutations of ubiquilin 2 (UBQLN2) have been identified to cause X-linked amyotrophic lateral sclerosis (ALS). Proteasome-mediated protein degradation is reported to be impaired by ALS-associated mutations of UBQLN2. However, it remains unkno
Externí odkaz:
https://doaj.org/article/2b339b24852d4d43bfeecbc6295ec171
Autor:
Yusei Yamada, Madoka Fukaura‐Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 8, Pp n/a-n/a (2023)
Abstract Background Niemann–Pick disease type C (NPC) is a fatal neurodegenerative disorder caused by abnormal intracellular cholesterol trafficking. Cyclodextrins (CDs), the most promising therapeutic candidates for NPC, but with concerns about ot
Externí odkaz:
https://doaj.org/article/4e90738b28c44e4c9ddaf53a1c5805b3
Autor:
Keita Kinoshita, Ayaka Yoshimizu, Yusei Ichihara, Keisuke Ushida, Shunsuke Kotani, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract We have previously reported that amodiaquine, a compound that binds to the ligand-binding domain of a nuclear receptor Nurr1, attenuates inflammatory responses and neurological deficits after intracerebral hemorrhage (ICH) in mice. 1,1-Bis(3
Externí odkaz:
https://doaj.org/article/4f09cdb37a164bf39a9a9502ed991cbb
Autor:
Yusei Yamada, Toru Miwa, Masaki Nakashima, Aina Shirakawa, Akira Ishii, Nanami Namba, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Yasuyo Okada, Atsushi Ichikawa, Katsumi Higaki, Ken Hayashi, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Yoshihide Ishikawa, Tomohito Kajii, Kyoko Tachii, Hiroki Takeda, Yorihisa Orita, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 155, Iss , Pp 113698- (2022)
Niemann–Pick disease type C (NPC) is a fatal disorder with abnormal intracellular cholesterol trafficking resulting in neurodegeneration and hepatosplenomegaly. A cyclic heptasaccharide with different degrees of substitution of 2-hydroxypropyl grou
Externí odkaz:
https://doaj.org/article/226ae786b7754b9d9a6eb4f06117e2c0
Autor:
Hiroshi Watanabe, Jing Bi, Ryota Murata, Rui Fujimura, Kento Nishida, Tadashi Imafuku, Yuka Nakamura, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Renal fibrosis is a major factor in the progression of chronic kidney disease and the final common pathway of kidney injury. Therefore, the effective therapies against renal fibrosis are urgently needed. The objective of this study was to in
Externí odkaz:
https://doaj.org/article/e6a55831e6dd47b6b8c66052bc944aec
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 3, Pp 116-123 (2020)
Neutrophils constitute the major population of infiltrating leukocytes after stroke including intracerebral hemorrhage (ICH), and these cells may exhibit pro-inflammatory and anti-inflammatory phenotypes depending on the external stimuli. Here we con
Externí odkaz:
https://doaj.org/article/f3da6247eca04df683a79e9d38260af6
Autor:
Yuki Kurauchi, Hari Prasad Devkota, Kengo Hori, Yuiko Nishihara, Akinori Hisatsune, Takahiro Seki, Hiroshi Katsuki
Publikováno v:
Journal of Functional Foods, Vol 59, Iss , Pp 301-308 (2019)
Matcha is thought to be beneficial for brain functions; however, only a few scientific studies have shown the effects of Matcha tea powder on psychiatric behavior. Here, we evaluated the anxiolytic activity of Matcha tea powder, and its hot water ext
Externí odkaz:
https://doaj.org/article/984ec60a50bc45caa84623f0c4c83bec
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 3, Pp 295-299 (2019)
We have previously reported that mice received intracerebroventricular injection of ouabain, an inhibitor of Na+, K+-ATPase, exhibited hyperactivity via overactivation of glutamatergic neurons. Here we investigated the effects of memantine, a blocker
Externí odkaz:
https://doaj.org/article/a01d644e2880471792166b90912a987d