Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yuki Kishino"'
Publikováno v:
Cancer Science
Trastuzumab deruxtecan (T‐DXd: DS‐8201a) is an anti‐human epidermal growth factor receptor 2 (HER2) Ab–drug conjugated with deruxtecan (DXd), a derivative of exatecan. The objective of this study was to characterize T‐DXd‐induced lung tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807be102341a357ba5854975bf84c214
https://doi.org/10.1111/cas.14686
https://doi.org/10.1111/cas.14686
Autor:
Yuki Kishino1 watanabe.yuki.w5@daiichisankyo.co.jp, Tomoko Hasegawa1, Takashi Yamoto2, Kazuhiko Mori2
Publikováno v:
Journal of Toxicological Sciences. 2019, Vol. 44 Issue 10, p701-709. 9p.
Autor:
Yuki Kishino1 watanabe.yuki.w5@daiichisankyo.co.jp, Tomoko Hasegawa1, Shingo Arakawa1, Yukari Shibaya1, Takashi Yamoto1, Kazuhiko Mori1
Publikováno v:
Journal of Toxicological Sciences. 2019, Vol. 44 Issue 3, p145-153. 9p.
Autor:
Takashi Yamoto, Kazuhiko Mori, Yumi Nishiya, Kyoko Watanabe, Yuki Kishino, Ayako Kato, Tomoko Hasegawa, Wataru Takasaki, Veronika Rozhnal
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 838:37-45
We investigated the relationship between metabolic activities of cytochrome P450 (CYP) isozymes present in microsomal fractions derived from the livers of 78 donors and micronucleus induction by cyclophosphamide (CPA). Consequently, a wide inter-indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee486c49bd6203dfc26b603a427f26b
https://doi.org/10.1016/j.mrgentox.2018.11.016
https://doi.org/10.1016/j.mrgentox.2018.11.016
Publikováno v:
The Journal of Toxicological Sciences. 44:145-153
A high incidence of positive results is obtained with in vitro genotoxicity tests, which do not correlate with the in vivo negative results in many cases. To address this issue, the metabolic profile of rat liver 9000 × g supernatant fraction (S9) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d686488b5cbfc9d0e0517a8b0897a4
https://doi.org/10.2131/jts.44.145
https://doi.org/10.2131/jts.44.145
Publikováno v:
The Journal of Toxicological Sciences. 44:701-709
Genotoxicity and carcinogenicity profiles of drugs occasionally vary across species due to species difference in drug metabolic profile. To clarify the effect of species differences in the metabolic profile on micronucleus induction, we conducted an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1740c84efbe952b3bcbd032df8739d8
https://doi.org/10.2131/jts.44.701
https://doi.org/10.2131/jts.44.701