Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Yuki Izawa"'
Autor:
Naoki Okamoto, Kenta Yagi, Sayaka Imawaka, Mayu Takaoka, Fuka Aizawa, Takahiro Niimura, Mitsuhiro Goda, Koji Miyata, Kei Kawada, Yuki Izawa‐Ishizawa, Satoshi Sakaguchi, Keisuke Ishizawa
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract In the treatment of chronic myeloid leukemia (CML), resistance to BCR‐ABL inhibitors makes it difficult to continue treatment and is directly related to life expectancy. Therefore, asciminib was introduced to the market as a useful drug fo
Externí odkaz:
https://doaj.org/article/eef81c91c9db4fafb2a4727bbd78f2ae
Autor:
Kei Kawada, Tomoaki Ishida, Hitoshi Fukuda, Yuki Hyohdoh, Toru Kubo, Tomoyuki Hamada, Yuichi Baba, Toshinobu Hayashi, Fuka Aizawa, Kenta Yagi, Yuki Izawa-Ishizawa, Takahiro Niimura, Shinji Abe, Mitsuhiro Goda, Hiroaki Kitaoka, Keisuke Ishizawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
IntroductionGuideline-directed medical therapy with renin-angiotensin system (RAS) inhibitors and beta-blockers has improved the survival of patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF). However, it is uncle
Externí odkaz:
https://doaj.org/article/e34bac9ce74848e2895ccbfef15b579c
Autor:
Kei Kawada, Tomoaki Ishida, Shumpei Morisawa, Kohei Jobu, Youichirou Higashi, Fuka Aizawa, Kenta Yagi, Yuki Izawa-Ishizawa, Takahiro Niimura, Shinji Abe, Mitsuhiro Goda, Mitsuhiko Miyamura, Keisuke Ishizawa
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundExosome-like nanoparticles (ELNs) mediate interspecies intercellular communications and modulate gene expression.Hypothesis/PurposeIn this study, we isolated and purified ELNs from the dried rhizome of Atractylodes lancea (Thunb.) DC. [Aste
Externí odkaz:
https://doaj.org/article/35bf5c89ac3848979fe09744549ec80b
Autor:
Toshihiko Yoshioka, Mitsuhiro Goda, Masaya Kanda, Sayuri Itobayashi, Yugo Sugimoto, Yuki Izawa‐Ishizawa, Kenta Yagi, Fuka Aizawa, Koji Miyata, Takahiro Niimura, Hirofumi Hamano, Takumi Sakurada, Yoshito Zamami, Keisuke Ishizawa
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2369-2381 (2023)
Abstract Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods. Sodium valproic acid is a prophylactic drug candidate with a high potential for
Externí odkaz:
https://doaj.org/article/029d32cf8617441b9f94b995356e25cd
Autor:
Takahiro Niimura, Mitsuhiro Goda, Koji Miyata, Jun Matsumoto, Toshihiko Yoshioka, Hirofumi Hamano, Fuka Aizawa, Kenta Yagi, Yuki Izawa-Ishizawa, Yoshito Zamami, Keisuke Ishizawa
Publikováno v:
Frontiers in Drug Safety and Regulation, Vol 3 (2023)
Introduction: The combination of atezolizumab, an immune checkpoint inhibitor (ICI), and bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor, is the first choice for systemic therapy in hepatocellular carcinoma. Immune-related cardiova
Externí odkaz:
https://doaj.org/article/8a1d42f6d3384d1e8455f73b217efc07
Autor:
Masaya Kanda, Mitsuhiro Goda, Akiko Maegawa, Toshihiko Yoshioka, Ami Yoshida, Koji Miyata, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Takumi Sakurada, Masayuki Chuma, Kenta Yagi, Yuki Izawa‐Ishizawa, Hiroaki Yanagawa, Yoshito Zamami, Keisuke Ishizawa
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 7, Pp 1664-1675 (2022)
Abstract Cisplatin is effective against many types of carcinoma. However, a high rate of renal damage is a clinical problem. Thus, there is a need to establish a method to prevent it. Although various compounds have been reported to be effective agai
Externí odkaz:
https://doaj.org/article/2c73c7c78bfc4986951826208aecdeae
Autor:
Mitsuhiro Goda, Masaya Kanda, Toshihiko Yoshioka, Ami Yoshida, Yoichi Murai, Yoshito Zamami, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Masayuki Chuma, Yuki Izawa‐Ishizawa, Keisuke Ishizawa
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1906-1916 (2021)
Abstract Nausea, vomiting, and renal injury are the common adverse effects associated with cisplatin. Cisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin‐induced kid
Externí odkaz:
https://doaj.org/article/4a9db6929fbe49b0a34703e1eadd2cde
Autor:
Tatsuya Tsuda, Masaki Imanishi, Mizuho Oogoshi, Mitsuhiro Goda, Yoshitaka Kihira, Yuya Horinouchi, Yoshito Zamami, Keisuke Ishizawa, Yasumasa Ikeda, Ichiro Hashimoto, Toshiaki Tamaki, Yuki Izawa-Ishizawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 3, Pp 109-115 (2020)
Arterial calcification, a risk factor of cardiovascular events, develops with differentiation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Cyclophilin A (CypA) is a peptidyl-prolyl isomerase involved in cardiovascular diseases
Externí odkaz:
https://doaj.org/article/94345c65ddb44ed0b26ff8fc9aff9134
Autor:
Yoshito Zamami, Hirofumi Hamano, Takahiro Niimura, Fuka Aizawa, Kenta Yagi, Mitsuhiro Goda, Yuki Izawa-Ishizawa, Keisuke Ishizawa
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Drug repositioning is a drug discovery strategy in which an existing drug is utilized as a therapeutic agent for a different disease. As information regarding the safety, pharmacokinetics, and formulation of existing drugs is already available, the c
Externí odkaz:
https://doaj.org/article/ad49ecbcdd4f43b79b4572f8b0d39f7e
Autor:
Yoshito Zamami, Takahiro Niimura, Toshihiro Koyama, Yuta Shigemi, Yuki Izawa-Ishizawa, Mizuki Morita, Ayako Ohshima, Keisaku Harada, Toru Imai, Hiromi Hagiwara, Naoto Okada, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Yutaka Kondo, Koichiro Tsuchiya, Shiro Hinotsu, Mitsunobu R. Kano, Keisuke Ishizawa
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that imp
Externí odkaz:
https://doaj.org/article/160330fc247d43b59aa3ba90d25cc60b